Skip to main content
NCBI home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1991 Dec;96:121–126. doi: 10.1289/ehp.9196121

Data selection and treatment of chemicals tested for genotoxicity and carcinogenicity.

N Loprieno 1, G Boncristiani 1, G Loprieno 1, M Tesoro 1
PMCID: PMC1568236  PMID: 1820253

Abstract

A database containing qualitative and quantitative results of experimental studies in the fields of genotoxicity and carcinogenicity has been developed. By analyzing results of the studies performed by the U.S. National Toxicology Program, or by a similar program developed in Japan, or reported in the scientific literature, as well performed by private organizations, information has been collected relating to 3389 chemicals, identified by their CAS number. The studies considered for the database include three genotoxicity/mutagenicity short-term test (STTs), namely, two in vitro (Salmonella, gene mutation assay, and mammalian cells/human lymphocytes chromosome aberration assay) and one in vivo, the rodent bone marrow micronucleus assay. To investigate the possible predictive value of these STT assays for carcinogenicity, the results of animal long-term bioassays have also been collected. We have re-evaluated all the genotoxicity studies and the majority of those cases studied in different laboratories with contrasting results has been resolved; a small proportion of questionable cases is, however, still present in the database. In total, 2898 (85.5%) of the chemicals have been tested in the Salmonella assay; 1399 (41.3%) have been tested in the in vitro chromosome aberration assay; 319 (9.4%) have been tested in the in vivo rodent bone marrow cell micronucleus assay; 716 (21.2%) of the chemicals have been tested in the in vivo animal long-term bioassay. For 1118 chemicals tested in the Salmonella assay, 30,650 quantitative studies have been included in the database, thus allowing a possible classification of mutagenic chemicals according to their mutagenic potency.(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

PDF
121

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson B. E., Zeiger E., Shelby M. D., Resnick M. A., Gulati D. K., Ivett J. L., Loveday K. S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 (Suppl 18):55–137. doi: 10.1002/em.2850160505. [DOI] [PubMed] [Google Scholar]
  2. Ashby J., Tennant R. W. Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutat Res. 1988 Jan;204(1):17–115. doi: 10.1016/0165-1218(88)90114-0. [DOI] [PubMed] [Google Scholar]
  3. Ashby J., Tennant R. W., Zeiger E., Stasiewicz S. Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. Mutat Res. 1989 Jun;223(2):73–103. doi: 10.1016/0165-1218(89)90037-2. [DOI] [PubMed] [Google Scholar]
  4. Ashby J. The prospects for a simplified and internationally harmonized approach to the detection of possible human carcinogens and mutagens. Mutagenesis. 1986 Jan;1(1):3–16. doi: 10.1093/mutage/1.1.3. [DOI] [PubMed] [Google Scholar]
  5. Enslein K., Blake B. W., Borgstedt H. H. Prediction of probability of carcinogenicity for a set of ongoing NTP bioassays. Mutagenesis. 1990 Jul;5(4):305–306. doi: 10.1093/mutage/5.4.305. [DOI] [PubMed] [Google Scholar]
  6. Galloway S. M., Bloom A. D., Resnick M., Margolin B. H., Nakamura F., Archer P., Zeiger E. Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ Mutagen. 1985;7(1):1–51. doi: 10.1002/em.2860070102. [DOI] [PubMed] [Google Scholar]
  7. Gulati D. K., Witt K., Anderson B., Zeiger E., Shelby M. D. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ Mol Mutagen. 1989;13(2):133–193. doi: 10.1002/em.2850130208. [DOI] [PubMed] [Google Scholar]
  8. Haworth S., Lawlor T., Mortelmans K., Speck W., Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 (Suppl 1):1–142. [PubMed] [Google Scholar]
  9. Hayashi M., Kishi M., Sofuni T., Ishidate M., Jr Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. Food Chem Toxicol. 1988 Jun;26(6):487–500. doi: 10.1016/0278-6915(88)90001-4. [DOI] [PubMed] [Google Scholar]
  10. Ishidate M., Jr, Harnois M. C., Sofuni T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res. 1988 Mar;195(2):151–213. doi: 10.1016/0165-1110(88)90023-1. [DOI] [PubMed] [Google Scholar]
  11. Ivett J. L., Brown B. M., Rodgers C., Anderson B. E., Resnick M. A., Zeiger E. Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ Mol Mutagen. 1989;14(3):165–187. doi: 10.1002/em.2850140306. [DOI] [PubMed] [Google Scholar]
  12. Lewis D. F., Ioannides C., Parke D. V. A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program. Mutagenesis. 1990 Sep;5(5):433–435. doi: 10.1093/mutage/5.5.433. [DOI] [PubMed] [Google Scholar]
  13. Loveday K. S., Lugo M. H., Resnick M. A., Anderson B. E., Zeiger E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. Environ Mol Mutagen. 1989;13(1):60–94. doi: 10.1002/em.2850130108. [DOI] [PubMed] [Google Scholar]
  14. Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 (Suppl 7):1–119. [PubMed] [Google Scholar]
  15. Rosenkranz H. S., Klopman G. Prediction of the carcinogenicity in rodents of chemicals currently being tested by the US National Toxicology Program: structure-activity correlations. Mutagenesis. 1990 Sep;5(5):425–432. doi: 10.1093/mutage/5.5.425. [DOI] [PubMed] [Google Scholar]
  16. Tennant R. W., Margolin B. H., Shelby M. D., Zeiger E., Haseman J. K., Spalding J., Caspary W., Resnick M., Stasiewicz S., Anderson B. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science. 1987 May 22;236(4804):933–941. doi: 10.1126/science.3554512. [DOI] [PubMed] [Google Scholar]
  17. Tennant R. W., Spalding J., Stasiewicz S., Ashby J. Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program. Mutagenesis. 1990 Jan;5(1):3–14. doi: 10.1093/mutage/5.1.3. [DOI] [PubMed] [Google Scholar]
  18. Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K., Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 (Suppl 9):1–109. [PubMed] [Google Scholar]
  19. Zeiger E., Haseman J. K., Shelby M. D., Margolin B. H., Tennant R. W. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals. Environ Mol Mutagen. 1990;16 (Suppl 18):1–14. doi: 10.1002/em.2850160502. [DOI] [PubMed] [Google Scholar]
  20. Zeiger E. Mutagenicity of 42 chemicals in Salmonella. Environ Mol Mutagen. 1990;16 (Suppl 18):32–54. doi: 10.1002/em.2850160504. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES