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. 1991 Dec;96:177–184. doi: 10.1289/ehp.9196177

Effects of ultraviolet light on the eye: role of protective glasses.

F J van Kuijk 1
PMCID: PMC1568237  PMID: 1820264

Abstract

Global atmospheric changes such as depletion of ozone in the stratosphere are thought to lead to increased levels of ultraviolet radiation on earth. This can have adverse effects on human health, and long-term effects of ultraviolet light on the eye are of increasing concern. Ultraviolet light exposure to the eye has been associated with cataract formation and retinal degeneration. In both cases, it is hypothesized that ultraviolet light can initiate formation of free radicals, which can cause protein modification and lipid peroxidation. Several procedures can be recommended to prevent ultraviolet light damage to the eye, such as the use of suitable protective glasses when outdoors.

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Selected References

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  1. Bhuyan K. C., Bhuyan D. K., Podos S. M. Lipid peroxidation in cataract of the human. Life Sci. 1986 Apr 21;38(16):1463–1471. doi: 10.1016/0024-3205(86)90559-x. [DOI] [PubMed] [Google Scholar]
  2. Bird R. P., Draper H. H. Comparative studies on different methods of malonaldehyde determination. Methods Enzymol. 1984;105:299–305. doi: 10.1016/s0076-6879(84)05038-2. [DOI] [PubMed] [Google Scholar]
  3. Bochow T. W., West S. K., Azar A., Munoz B., Sommer A., Taylor H. R. Ultraviolet light exposure and risk of posterior subcapsular cataracts. Arch Ophthalmol. 1989 Mar;107(3):369–372. doi: 10.1001/archopht.1989.01070010379027. [DOI] [PubMed] [Google Scholar]
  4. Borchman D., Yappert M. C., Rubini R. Q., Paterson C. A. Distribution of phospholipid-malondialdehyde-adduct in the human lens. Curr Eye Res. 1989 Sep;8(9):939–946. [PubMed] [Google Scholar]
  5. Borgwardt B., Fishman G. A., Vander-Meulen D. Spectral transmission characteristics of tinted lenses. Arch Ophthalmol. 1981 Feb;99(2):293–297. doi: 10.1001/archopht.1981.03930010295015. [DOI] [PubMed] [Google Scholar]
  6. Borkman R. F., Lerman S. Evidence for a free radical mechanism in aging and u.v.-irradiated ocular lenses. Exp Eye Res. 1977 Sep;25(3):303–309. doi: 10.1016/0014-4835(77)90097-5. [DOI] [PubMed] [Google Scholar]
  7. Bressler N. M., Bressler S. B., Fine S. L. Age-related macular degeneration. Surv Ophthalmol. 1988 May-Jun;32(6):375–413. doi: 10.1016/0039-6257(88)90052-5. [DOI] [PubMed] [Google Scholar]
  8. Cheng H. Causes of cataract. BMJ. 1989 Jun 3;298(6686):1470–1471. doi: 10.1136/bmj.298.6686.1470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cosgrove J. P., Church D. F., Pryor W. A. The kinetics of the autoxidation of polyunsaturated fatty acids. Lipids. 1987 May;22(5):299–304. doi: 10.1007/BF02533996. [DOI] [PubMed] [Google Scholar]
  10. Cross C. E., Halliwell B., Borish E. T., Pryor W. A., Ames B. N., Saul R. L., McCord J. M., Harman D. Oxygen radicals and human disease. Ann Intern Med. 1987 Oct;107(4):526–545. doi: 10.7326/0003-4819-107-4-526. [DOI] [PubMed] [Google Scholar]
  11. Dratz E. A., Farnsworth C. C., Loew E. C., Stephens R. J., Thomas D. W., Van Kuijk F. J. Products in vivo peroxidation are present in tissues of vitamin E-deficient rats and dogs. Ann N Y Acad Sci. 1989;570:46–60. doi: 10.1111/j.1749-6632.1989.tb14907.x. [DOI] [PubMed] [Google Scholar]
  12. Ederer F., Hiller R., Taylor H. R. Senile lens changes and diabetes in two population studies. Am J Ophthalmol. 1981 Mar;91(3):381–395. doi: 10.1016/0002-9394(81)90293-2. [DOI] [PubMed] [Google Scholar]
  13. Gardner T. W., Ai E., Chrobak M., Shoch D. E. Photic maculopathy secondary to short-circuiting of a high-tension electric current. Ophthalmology. 1982 Jul;89(7):865–868. doi: 10.1016/s0161-6420(82)34712-0. [DOI] [PubMed] [Google Scholar]
  14. Ham W. T., Jr, Mueller H. A., Ruffolo J. J., Jr, Guerry D., 3rd, Guerry R. K. Action spectrum for retinal injury from near-ultraviolet radiation in the aphakic monkey. Am J Ophthalmol. 1982 Mar;93(3):299–306. doi: 10.1016/0002-9394(82)90529-3. [DOI] [PubMed] [Google Scholar]
  15. Ham W. T., Jr, Mueller H. A., Sliney D. H. Retinal sensitivity to damage from short wavelength light. Nature. 1976 Mar 11;260(5547):153–155. doi: 10.1038/260153a0. [DOI] [PubMed] [Google Scholar]
  16. Harmful effects of ultraviolet radiation. Council on Scientific Affairs. JAMA. 1989 Jul 21;262(3):380–384. [PubMed] [Google Scholar]
  17. Hiller R., Giacometti L., Yuen K. Sunlight and cataract: an epidemiologic investigation. Am J Epidemiol. 1977 May;105(5):450–459. doi: 10.1093/oxfordjournals.aje.a112404. [DOI] [PubMed] [Google Scholar]
  18. Hiller R., Sperduto R. D., Ederer F. Epidemiologic associations with nuclear, cortical, and posterior subcapsular cataracts. Am J Epidemiol. 1986 Dec;124(6):916–925. doi: 10.1093/oxfordjournals.aje.a114481. [DOI] [PubMed] [Google Scholar]
  19. Jacques P. F., Chylack L. T., Jr, McGandy R. B., Hartz S. C. Antioxidant status in persons with and without senile cataract. Arch Ophthalmol. 1988 Mar;106(3):337–340. doi: 10.1001/archopht.1988.01060130363022. [DOI] [PubMed] [Google Scholar]
  20. Jacques P. F., Hartz S. C., Chylack L. T., Jr, McGandy R. B., Sadowski J. A. Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels. Am J Clin Nutr. 1988 Jul;48(1):152–158. doi: 10.1093/ajcn/48.1.152. [DOI] [PubMed] [Google Scholar]
  21. Jedziniak J., Arredondo M., Andley U. Oxidative damage to human lens enzymes. Curr Eye Res. 1987 Feb;6(2):345–350. doi: 10.3109/02713688709025186. [DOI] [PubMed] [Google Scholar]
  22. Johnson F. S., Mo T., Green A. E. Average latitudinal variation in ultraviolet radiation at the earth's surface. Photochem Photobiol. 1976 Mar;23(3):179–188. doi: 10.1111/j.1751-1097.1976.tb07239.x. [DOI] [PubMed] [Google Scholar]
  23. Katz M. L., Stone W. L., Dratz E. A. Fluorescent pigment accumulation in retinal pigment epithelium of antioxidant-deficient rats. Invest Ophthalmol Vis Sci. 1978 Nov;17(11):1049–1058. [PubMed] [Google Scholar]
  24. Lerman S., Megaw J. M., Moran M. N. Further studies on the effects of UV radiation on the human lens. Ophthalmic Res. 1985;17(6):354–361. doi: 10.1159/000265401. [DOI] [PubMed] [Google Scholar]
  25. Lerman S. Ocular phototoxicity. N Engl J Med. 1988 Dec 1;319(22):1475–1477. doi: 10.1056/NEJM198812013192208. [DOI] [PubMed] [Google Scholar]
  26. Lerman S. Photosensitizing drugs and their possible role in enhancing ocular toxicity. Parker Heath memorial lecture. Ophthalmology. 1986 Mar;93(3):304–318. doi: 10.1016/s0161-6420(86)33749-7. [DOI] [PubMed] [Google Scholar]
  27. Lipman R. M., Tripathi B. J., Tripathi R. C. Cataracts induced by microwave and ionizing radiation. Surv Ophthalmol. 1988 Nov-Dec;33(3):200–210. doi: 10.1016/0039-6257(88)90088-4. [DOI] [PubMed] [Google Scholar]
  28. Liu I. Y., White L., LaCroix A. Z. The association of age-related macular degeneration and lens opacities in the aged. Am J Public Health. 1989 Jun;79(6):765–769. doi: 10.2105/ajph.79.6.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Magnante D. B., Miller D. Ultraviolet absorption of commonly used clip-on sunglasses. Ann Ophthalmol. 1985 Oct;17(10):614–616. [PubMed] [Google Scholar]
  30. Marshall J. Structural aspects of laser-induced damage and their functional implications. Health Phys. 1989 May;56(5):617–624. doi: 10.1097/00004032-198905000-00003. [DOI] [PubMed] [Google Scholar]
  31. Marx J. L. Oxygen free radicals linked to many diseases. Science. 1987 Jan 30;235(4788):529–531. doi: 10.1126/science.3810154. [DOI] [PubMed] [Google Scholar]
  32. McDonagh A. F., Nguyen M. L. Spectacles, ultraviolet radiation, and formation of cataracts. N Engl J Med. 1989 Nov 23;321(21):1478–1479. doi: 10.1056/nejm198911233212114. [DOI] [PubMed] [Google Scholar]
  33. Miller S. A., James R. H. Variables associated with ultraviolet transmittance measurements of intraocular lenses. Am J Ophthalmol. 1988 Sep 15;106(3):256–260. doi: 10.1016/0002-9394(88)90357-1. [DOI] [PubMed] [Google Scholar]
  34. Molenaar I., Hulstaert C. E., Vos J. Membrane characteristics in vitamin E deficiency and the assessment of vitamin E status. Proc Nutr Soc. 1973 Dec;32(3):249–254. doi: 10.1079/pns19730047. [DOI] [PubMed] [Google Scholar]
  35. Morrison J. C., Morrison F. S. Prophylactic transfusions in pregnant patients with sickle cell disease. N Engl J Med. 1989 May 11;320(19):1286–1287. doi: 10.1056/NEJM198905113201922. [DOI] [PubMed] [Google Scholar]
  36. Noell W. K. Effects of environmental lighting and dietary vitamin A on the vulnerability of the retina to light damage. Photochem Photobiol. 1979 Apr;29(4):717–723. doi: 10.1111/j.1751-1097.1979.tb07756.x. [DOI] [PubMed] [Google Scholar]
  37. Noell W. K., Walker V. S., Kang B. S., Berman S. Retinal damage by light in rats. Invest Ophthalmol. 1966 Oct;5(5):450–473. [PubMed] [Google Scholar]
  38. Olson C. M. Increased outdoor recreation, diminished ozone layer pose ultraviolet radiation threat to eye. JAMA. 1989 Feb 24;261(8):1102–1103. [PubMed] [Google Scholar]
  39. Parver L. M., Auker C. R., Fine B. S. Observations on monkey eyes exposed to light from an operating microscope. Ophthalmology. 1983 Aug;90(8):964–972. doi: 10.1016/s0161-6420(83)80024-4. [DOI] [PubMed] [Google Scholar]
  40. Rapp L. M., Tolman B. L., Dhindsa H. S. Separate mechanisms for retinal damage by ultraviolet-A and mid-visible light. Invest Ophthalmol Vis Sci. 1990 Jun;31(6):1186–1190. [PubMed] [Google Scholar]
  41. Rathbun W. B., Bovis M. G. Activity of glutathione peroxidase and glutathione reductase in the human lens related to age. Curr Eye Res. 1986 May;5(5):381–385. doi: 10.3109/02713688609025177. [DOI] [PubMed] [Google Scholar]
  42. Robertson D. M., McLaren J. W. Photic retinopathy from the operating room microscope. Study with filters. Arch Ophthalmol. 1989 Mar;107(3):373–375. doi: 10.1001/archopht.1989.01070010383028. [DOI] [PubMed] [Google Scholar]
  43. Rosenthal F. S., Bakalian A. E., Lou C. Q., Taylor H. R. The effect of sunglasses on ocular exposure to ultraviolet radiation. Am J Public Health. 1988 Jan;78(1):72–74. doi: 10.2105/ajph.78.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Rosenthal F. S., Bakalian A. E., Taylor H. R. The effect of prescription eyewear on ocular exposure to ultraviolet radiation. Am J Public Health. 1986 Oct;76(10):1216–1220. doi: 10.2105/ajph.76.10.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Rosenthal F. S., Phoon C., Bakalian A. E., Taylor H. R. The ocular dose of ultraviolet radiation to outdoor workers. Invest Ophthalmol Vis Sci. 1988 Apr;29(4):649–656. [PubMed] [Google Scholar]
  46. Rosenthal F. S., Safran M., Taylor H. R. The ocular dose of ultraviolet radiation from sunlight exposure. Photochem Photobiol. 1985 Aug;42(2):163–171. doi: 10.1111/j.1751-1097.1985.tb01555.x. [DOI] [PubMed] [Google Scholar]
  47. Sadun A. C., Sadun A. A., Sadun L. A. Solar retinopathy. A biophysical analysis. Arch Ophthalmol. 1984 Oct;102(10):1510–1512. doi: 10.1001/archopht.1984.01040031230024. [DOI] [PubMed] [Google Scholar]
  48. Sample P. A., Esterson F. D., Weinreb R. N., Boynton R. M. The aging lens: in vivo assessment of light absorption in 84 human eyes. Invest Ophthalmol Vis Sci. 1988 Aug;29(8):1306–1311. [PubMed] [Google Scholar]
  49. Sauter C. Why the color white is vital for the leukocyte. N Engl J Med. 1989 Nov 23;321(21):1479–1480. doi: 10.1056/NEJM198911233212115. [DOI] [PubMed] [Google Scholar]
  50. Sauter C. Why the color white is vital for the leukocyte. N Engl J Med. 1989 Nov 23;321(21):1479–1480. doi: 10.1056/NEJM198911233212115. [DOI] [PubMed] [Google Scholar]
  51. Simonelli F., Nesti A., Pensa M., Romano L., Savastano S., Rinaldi E., Auricchio G. Lipid peroxidation and human cataractogenesis in diabetes and severe myopia. Exp Eye Res. 1989 Aug;49(2):181–187. doi: 10.1016/0014-4835(89)90088-2. [DOI] [PubMed] [Google Scholar]
  52. Sliney D. H. Eye protective techniques for bright light. Ophthalmology. 1983 Aug;90(8):937–944. doi: 10.1016/s0161-6420(83)80021-9. [DOI] [PubMed] [Google Scholar]
  53. Smolen J. E., Shohet S. B. Permeability changes induced by peroxidation in liposomes prepared from human erythrocyte lipids. J Lipid Res. 1974 May;15(3):273–280. [PubMed] [Google Scholar]
  54. Stambolian D. Galactose and cataract. Surv Ophthalmol. 1988 Mar-Apr;32(5):333–349. doi: 10.1016/0039-6257(88)90095-1. [DOI] [PubMed] [Google Scholar]
  55. Stone W. L., Farnsworth C. C., Dratz E. A. A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments. Exp Eye Res. 1979 Apr;28(4):387–397. doi: 10.1016/0014-4835(79)90114-3. [DOI] [PubMed] [Google Scholar]
  56. Taylor H. R. The biological effects of UV-B on the eye. Photochem Photobiol. 1989 Oct;50(4):489–492. doi: 10.1111/j.1751-1097.1989.tb05553.x. [DOI] [PubMed] [Google Scholar]
  57. Taylor H. R., West S. K., Rosenthal F. S., Muñoz B., Newland H. S., Abbey H., Emmett E. A. Effect of ultraviolet radiation on cataract formation. N Engl J Med. 1988 Dec 1;319(22):1429–1433. doi: 10.1056/NEJM198812013192201. [DOI] [PubMed] [Google Scholar]
  58. Ultraviolet radiation and formation of cataracts. N Engl J Med. 1989 May 11;320(19):1285–1286. doi: 10.1056/NEJM198905113201921. [DOI] [PubMed] [Google Scholar]
  59. Ultraviolet radiation and formation of cataracts. N Engl J Med. 1989 May 11;320(19):1285–1286. doi: 10.1056/NEJM198905113201921. [DOI] [PubMed] [Google Scholar]
  60. Weiter J. J. Macular degeneration. Is there a nutritional component? Arch Ophthalmol. 1988 Feb;106(2):183–184. doi: 10.1001/archopht.1988.01060130193022. [DOI] [PubMed] [Google Scholar]
  61. Werner J. S. Development of scotopic sensitivity and the absorption spectrum of the human ocular media. J Opt Soc Am. 1982 Feb;72(2):247–258. doi: 10.1364/josa.72.000247. [DOI] [PubMed] [Google Scholar]
  62. West S. K., Rosenthal F. S., Bressler N. M., Bressler S. B., Munoz B., Fine S. L., Taylor H. R. Exposure to sunlight and other risk factors for age-related macular degeneration. Arch Ophthalmol. 1989 Jun;107(6):875–879. doi: 10.1001/archopht.1989.01070010897038. [DOI] [PubMed] [Google Scholar]
  63. Wiegand R. D., Giusto N. M., Rapp L. M., Anderson R. E. Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1433–1435. [PubMed] [Google Scholar]
  64. Wiegand R. D., Joel C. D., Rapp L. M., Nielsen J. C., Maude M. B., Anderson R. E. Polyunsaturated fatty acids and vitamin E in rat rod outer segments during light damage. Invest Ophthalmol Vis Sci. 1986 May;27(5):727–733. [PubMed] [Google Scholar]
  65. Wing G. L., Blanchard G. C., Weiter J. J. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1978 Jul;17(7):601–607. [PubMed] [Google Scholar]
  66. Young R. W. Pathophysiology of age-related macular degeneration. Surv Ophthalmol. 1987 Mar-Apr;31(5):291–306. doi: 10.1016/0039-6257(87)90115-9. [DOI] [PubMed] [Google Scholar]
  67. Young R. W. Solar radiation and age-related macular degeneration. Surv Ophthalmol. 1988 Jan-Feb;32(4):252–269. doi: 10.1016/0039-6257(88)90174-9. [DOI] [PubMed] [Google Scholar]
  68. Zigman S., Datiles M., Torczynski E. Sunlight and human cataracts. Invest Ophthalmol Vis Sci. 1979 May;18(5):462–467. [PubMed] [Google Scholar]
  69. van Kuijk F. J., Dratz E. A. Detection of phospholipid peroxides in biological samples. Free Radic Biol Med. 1987;3(5):349–354. doi: 10.1016/s0891-5849(87)80046-1. [DOI] [PubMed] [Google Scholar]
  70. van Kuijk F. J., Thomas D. W., Stephens R. J., Dratz E. A. Gas chromatography-mass spectrometry method for determination of phospholipid peroxides; I. Transesterification to form methyl esters. J Free Radic Biol Med. 1985;1(3):215–225. doi: 10.1016/0748-5514(85)90121-7. [DOI] [PubMed] [Google Scholar]
  71. van Kuijk F. J., Thomas D. W., Stephens R. J., Dratz E. A. Gas chromatography-mass spectrometry method for determination of phospholipid peroxides; II. Transesterification to form pentafluorobenzyl esters and detection with picogram sensitivity. J Free Radic Biol Med. 1985;1(5-6):387–393. doi: 10.1016/0748-5514(85)90151-5. [DOI] [PubMed] [Google Scholar]
  72. van Kuijk F. J., Thomas D. W., Stephens R. J., Dratz E. A. Occurrence of 4-hydroxyalkenals in rat tissues determined as pentafluorobenzyl oxime derivatives by gas chromatography-mass spectrometry. Biochem Biophys Res Commun. 1986 Aug 29;139(1):144–149. doi: 10.1016/s0006-291x(86)80091-2. [DOI] [PubMed] [Google Scholar]

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