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. 1991 Nov;95:147–156. doi: 10.1289/ehp.9195147

Extremely low frequency electromagnetic fields and cancer: the epidemiologic evidence.

M N Bates 1
PMCID: PMC1568419  PMID: 1821368

Abstract

This paper reviews the epidemiologic evidence that low frequency electromagnetic fields generated by alternating current may be a cause of cancer. Studies examining residential exposures of children and adults and studies of electrical and electronics workers are reviewed. Using conventional epidemiologic criteria for inferring causal associations, including strength and consistency of the relationship, biological plausibility, and the possibility of bias as an explanation, it is concluded that the evidence is strongly suggestive that such radiation is carcinogenic. The evidence is strongest for brain and central nervous system cancers in electrical workers and children. Weaker evidence supports an association with leukemia in electrical workers. Some evidence also exists for an association with melanoma in electrical workers. Failure to find consistent evidence of a link between residential exposures and adult cancers may be attributable to exposure misclassification. Studies so far have used imperfect surrogates for any true biologically effective magnetic field exposure. The resulting exposure misclassification has produced relative risk estimates that understate any true risk.

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Selected References

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  1. Bunin G. R., Ward E., Kramer S., Rhee C. A., Meadows A. T. Neuroblastoma and parental occupation. Am J Epidemiol. 1990 May;131(5):776–780. doi: 10.1093/oxfordjournals.aje.a115568. [DOI] [PubMed] [Google Scholar]
  2. Calle E. E., Savitz D. A. Leukemia in occupational groups with presumed exposure to electrical and magnetic fields. N Engl J Med. 1985 Dec 5;313(23):1476–1477. doi: 10.1056/nejm198512053132312. [DOI] [PubMed] [Google Scholar]
  3. Cammarano G., Crosignani P., Berrino F., Berra G. Cancer mortality among workers in a thermoelectric power plant. Scand J Work Environ Health. 1984 Aug;10(4):259–261. doi: 10.5271/sjweh.2333. [DOI] [PubMed] [Google Scholar]
  4. Coleman M. P., Bell C. M., Taylor H. L., Primic-Zakelj M. Leukaemia and residence near electricity transmission equipment: a case-control study. Br J Cancer. 1989 Nov;60(5):793–798. doi: 10.1038/bjc.1989.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davis D. L., Hoel D., Fox J., Lopez A. International trends in cancer mortality in France, West Germany, Italy, Japan, England and Wales, and the USA. Lancet. 1990 Aug 25;336(8713):474–481. doi: 10.1016/0140-6736(90)92020-i. [DOI] [PubMed] [Google Scholar]
  6. Flodin U., Fredriksson M., Persson B., Hardell L., Axelson O. Background radiation, electrical work, and some other exposures associated with acute myeloid leukemia in a case-referent study. Arch Environ Health. 1986 Mar-Apr;41(2):77–84. doi: 10.1080/00039896.1986.9937413. [DOI] [PubMed] [Google Scholar]
  7. Fulton J. P., Cobb S., Preble L., Leone L., Forman E. Electrical wiring configurations and childhood leukemia in Rhode Island. Am J Epidemiol. 1980 Mar;111(3):292–296. doi: 10.1093/oxfordjournals.aje.a112899. [DOI] [PubMed] [Google Scholar]
  8. Jacobson-Kram D., Montalbano D. The reproductive effects assessment group's report on the mutagenicity of inorganic arsenic. Environ Mutagen. 1985;7(5):787–804. doi: 10.1002/em.2860070515. [DOI] [PubMed] [Google Scholar]
  9. Lin R. S., Dischinger P. C., Conde J., Farrell K. P. Occupational exposure to electromagnetic fields and the occurrence of brain tumors. An analysis of possible associations. J Occup Med. 1985 Jun;27(6):413–419. [PubMed] [Google Scholar]
  10. McDowall M. E. Leukemia mortality in electrical workers in England and Wales. Lancet. 1983 Jan 29;1(8318):246–246. doi: 10.1016/s0140-6736(83)92624-7. [DOI] [PubMed] [Google Scholar]
  11. McDowall M. E. Mortality of persons resident in the vicinity of electricity transmission facilities. Br J Cancer. 1986 Feb;53(2):271–279. doi: 10.1038/bjc.1986.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McLaughlin J. K., Hrubec Z., Linet M. S., Heineman E. F., Blot W. J., Fraumeni J. F., Jr Cigarette smoking and leukemia. J Natl Cancer Inst. 1989 Aug 16;81(16):1262–1263. doi: 10.1093/jnci/81.16.1262. [DOI] [PubMed] [Google Scholar]
  13. Milham S., Jr Mortality from leukemia in workers exposed to electrical and magnetic fields. N Engl J Med. 1982 Jul 22;307(4):249–249. doi: 10.1056/nejm198207223070412. [DOI] [PubMed] [Google Scholar]
  14. Milham S., Jr Mortality in workers exposed to electromagnetic fields. Environ Health Perspect. 1985 Oct;62:297–300. doi: 10.1289/ehp.8562297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Milham S., Jr Silent keys: leukaemia mortality in amateur radio operators. Lancet. 1985 Apr 6;1(8432):812–812. doi: 10.1016/s0140-6736(85)91463-1. [DOI] [PubMed] [Google Scholar]
  16. Nasca P. C., Baptiste M. S., MacCubbin P. A., Metzger B. B., Carlton K., Greenwald P., Armbrustmacher V. W., Earle K. M., Waldman J. An epidemiologic case-control study of central nervous system tumors in children and parental occupational exposures. Am J Epidemiol. 1988 Dec;128(6):1256–1265. doi: 10.1093/oxfordjournals.aje.a115079. [DOI] [PubMed] [Google Scholar]
  17. Olin R., Vågerö D., Ahlbom A. Mortality experience of electrical engineers. Br J Ind Med. 1985 Mar;42(3):211–212. doi: 10.1136/oem.42.3.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Pearce N. E., Sheppard R. A., Howard J. K., Fraser J., Lilley B. M. Leukaemia in electrical workers in New Zealand. Lancet. 1985 Apr 6;1(8432):811–812. doi: 10.1016/s0140-6736(85)91462-x. [DOI] [PubMed] [Google Scholar]
  19. Pearce N., Reif J., Fraser J. Case-control studies of cancer in New Zealand electrical workers. Int J Epidemiol. 1989 Mar;18(1):55–59. doi: 10.1093/ije/18.1.55. [DOI] [PubMed] [Google Scholar]
  20. Preston-Martin S., Henderson B. E., Peters J. M. Descriptive epidemiology of central nervous system neoplasms in Los Angeles County. Ann N Y Acad Sci. 1982;381:202–208. doi: 10.1111/j.1749-6632.1982.tb50386.x. [DOI] [PubMed] [Google Scholar]
  21. Preston-Martin S., Peters J. M., Yu M. C., Garabrant D. H., Bowman J. D. Myelogenous leukemia and electric blanket use. Bioelectromagnetics. 1988;9(3):207–213. doi: 10.1002/bem.2250090302. [DOI] [PubMed] [Google Scholar]
  22. Savitz D. A., Calle E. E. Leukemia and occupational exposure to electromagnetic fields: review of epidemiologic surveys. J Occup Med. 1987 Jan;29(1):47–51. [PubMed] [Google Scholar]
  23. Savitz D. A., John E. M., Kleckner R. C. Magnetic field exposure from electric appliances and childhood cancer. Am J Epidemiol. 1990 May;131(5):763–773. doi: 10.1093/oxfordjournals.aje.a115566. [DOI] [PubMed] [Google Scholar]
  24. Savitz D. A., Pearce N. E., Poole C. Methodological issues in the epidemiology of electromagnetic fields and cancer. Epidemiol Rev. 1989;11:59–78. doi: 10.1093/oxfordjournals.epirev.a036045. [DOI] [PubMed] [Google Scholar]
  25. Savitz D. A., Wachtel H., Barnes F. A., John E. M., Tvrdik J. G. Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. Am J Epidemiol. 1988 Jul;128(1):21–38. doi: 10.1093/oxfordjournals.aje.a114943. [DOI] [PubMed] [Google Scholar]
  26. Severson R. K., Davis S., Heuser L., Daling J. R., Thomas D. B. Cigarette smoking and acute nonlymphocytic leukemia. Am J Epidemiol. 1990 Sep;132(3):418–422. doi: 10.1093/oxfordjournals.aje.a115676. [DOI] [PubMed] [Google Scholar]
  27. Severson R. K., Stevens R. G., Kaune W. T., Thomas D. B., Heuser L., Davis S., Sever L. E. Acute nonlymphocytic leukemia and residential exposure to power frequency magnetic fields. Am J Epidemiol. 1988 Jul;128(1):10–20. doi: 10.1093/oxfordjournals.aje.a114932. [DOI] [PubMed] [Google Scholar]
  28. Sorahan T., Waterhouse J. A., McKiernan M. J., Aston R. H. Cancer incidence and cancer mortality in a cohort of semiconductor workers. Br J Ind Med. 1985 Aug;42(8):546–550. doi: 10.1136/oem.42.8.546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Speers M. A., Dobbins J. G., Miller V. S. Occupational exposures and brain cancer mortality: a preliminary study of east Texas residents. Am J Ind Med. 1988;13(6):629–638. doi: 10.1002/ajim.4700130603. [DOI] [PubMed] [Google Scholar]
  30. Spitz M. R., Johnson C. C. Neuroblastoma and paternal occupation. A case-control analysis. Am J Epidemiol. 1985 Jun;121(6):924–929. doi: 10.1093/oxfordjournals.aje.a114062. [DOI] [PubMed] [Google Scholar]
  31. Stern F. B., Waxweiler R. A., Beaumont J. J., Lee S. T., Rinsky R. A., Zumwalde R. D., Halperin W. E., Bierbaum P. J., Landrigan P. J., Murray W. E., Jr A case-control study of leukemia at a naval nuclear shipyard. Am J Epidemiol. 1986 Jun;123(6):980–992. doi: 10.1093/oxfordjournals.aje.a114350. [DOI] [PubMed] [Google Scholar]
  32. Thomas T. L., Stolley P. D., Stemhagen A., Fontham E. T., Bleecker M. L., Stewart P. A., Hoover R. N. Brain tumor mortality risk among men with electrical and electronics jobs: a case-control study. J Natl Cancer Inst. 1987 Aug;79(2):233–238. [PubMed] [Google Scholar]
  33. Tomenius L. 50-Hz electromagnetic environment and the incidence of childhood tumors in Stockholm County. Bioelectromagnetics. 1986;7(2):191–207. doi: 10.1002/bem.2250070209. [DOI] [PubMed] [Google Scholar]
  34. Törnqvist S., Norell S., Ahlbom A., Knave B. Cancer in the electric power industry. Br J Ind Med. 1986 Mar;43(3):212–213. doi: 10.1136/oem.43.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Verreault R., Weiss N. S., Hollenbach K. A., Strader C. H., Daling J. R. Use of electric blankets and risk of testicular cancer. Am J Epidemiol. 1990 May;131(5):759–762. doi: 10.1093/oxfordjournals.aje.a115565. [DOI] [PubMed] [Google Scholar]
  36. Vågerö D., Ahlbom A., Olin R., Sahlsten S. Cancer morbidity among workers in the telecommunications industry. Br J Ind Med. 1985 Mar;42(3):191–195. doi: 10.1136/oem.42.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Vågerö D., Olin R. Incidence of cancer in the electronics industry: using the new Swedish Cancer Environment Registry as a screening instrument. Br J Ind Med. 1983 May;40(2):188–192. doi: 10.1136/oem.40.2.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Wertheimer N., Leeper E. Adult cancer related to electrical wires near the home. Int J Epidemiol. 1982 Dec;11(4):345–355. doi: 10.1093/ije/11.4.345. [DOI] [PubMed] [Google Scholar]
  39. Wertheimer N., Leeper E. Electrical wiring configurations and childhood cancer. Am J Epidemiol. 1979 Mar;109(3):273–284. doi: 10.1093/oxfordjournals.aje.a112681. [DOI] [PubMed] [Google Scholar]
  40. Wertheimer N., Leeper E. Re: "Acute Nonlymphocytic Leukemia and Residential Exposure to Power-Frequency Magnetic Fields". Am J Epidemiol. 1989 Aug;130(2):423–427. doi: 10.1093/oxfordjournals.aje.a115351. [DOI] [PubMed] [Google Scholar]
  41. Wiklund K., Einhorn J., Eklund G. An application of the Swedish Cancer-Environment Registry. Leukaemia among telephone operators at the telecommunications administration in Sweden. Int J Epidemiol. 1981 Dec;10(4):373–376. doi: 10.1093/ije/10.4.373. [DOI] [PubMed] [Google Scholar]
  42. Wilkins J. R., 3rd, Hundley V. D. Paternal occupational exposure to electromagnetic fields and neuroblastoma in offspring. Am J Epidemiol. 1990 Jun;131(6):995–1008. doi: 10.1093/oxfordjournals.aje.a115620. [DOI] [PubMed] [Google Scholar]
  43. Wright W. E., Peters J. M., Mack T. M. Leukaemia in workers exposed to electrical and magnetic fields. Lancet. 1982 Nov 20;2(8308):1160–1161. doi: 10.1016/s0140-6736(82)92814-8. [DOI] [PubMed] [Google Scholar]

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