Abstract
Male mice (Q strain) received two consecutive injections of organophosphorus insecticides: a phosphonate (trichlorfon) was combined to a thiophosphate (methylparathion) or a dithiophosphate (malathion or methylazinphos) in order to evaluate the interactions at the genetic and cytogenetic levels. No increase in chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. In a dominant lethal mutation assay, the frequency of postimplantation lethality was not significantly increased over the control level. The percentage of preimplantation losses was enhanced, probably due to a toxic effect on male germ cells.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Degraeve N., Moutschen J. Absence of genetic and cytogenetic effects in mice treated by the organophosphorus insecticide parathion, its methyl analogue, and paraoxon. Toxicology. 1984 Aug;32(2):177–183. doi: 10.1016/0300-483x(84)90136-7. [DOI] [PubMed] [Google Scholar]
- MURPHY S. D., ANDERSON R. L., DUBOIS K. P. Potentiation of toxicity of malathion by triorthotolyl phosphate. Proc Soc Exp Biol Med. 1959 Mar;100(3):483–487. doi: 10.3181/00379727-100-24668. [DOI] [PubMed] [Google Scholar]
- Moutschen-Dahmen J., Moutschen-Dahmen M., Degraeve N. Metrifonate and dichlorvos: cytogenetic investigations. Acta Pharmacol Toxicol (Copenh) 1981;49 (Suppl 5):29–39. doi: 10.1111/j.1600-0773.1981.tb03250.x. [DOI] [PubMed] [Google Scholar]