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. 1981 Dec;42:187–195. doi: 10.1289/ehp.8142187

Comparative toxicity and tissue distribution of lead acetate in weanling and adult rats.

J I Rader, J T Peeler, K R Mahaffey
PMCID: PMC1568802  PMID: 7333253

Abstract

The relative toxicity of low doses of lead acetate provided steadily in drinking water or by mouth once per week was studied in weanling and adult rats. Free erythrocyte protoporphyrin and urinary delta-aminolevulinic acid levels were measured, as well as lead levels in blood and kidney. The accumulation of lead in brain tissue and in bone (femur) was measured to determine the effect of age and schedule of administration on tissue distribution and retention of lead. Total intakes of lead during the 60-week experimental period were: weanling and adult rats exposed to drinking water supplemented with 200 microgram of lead acetate/ml: 127 +/- 10 mg and 160 +/- 16 mg, respectively; weanling and adult rats dosed with lead acetate orally once per week: 132 mg and 161 mg, respectively. Increased toxic effects of lead in the weanling animals were apparent in most of the parameters measured (urinary delta-aminolevulinic acid and blood, brain, femur and kidney lead levels). This pattern was observed in weanling rats exposed to lead steadily through drinking water or dosed orally with an equivalent quantity of lead once per week. Lead levels in blood were highly correlated with the accumulation of lead in brain, femur, and kidney tissue in both groups of weanling rats. In adult rats, significant correlations between blood lead and kidney lead and between blood lead and femur lead were found only in the rats receiving lead steadily in drinking water.

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Selected References

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  1. Alexander F. W. The uptake of lead by children in differing environments. Environ Health Perspect. 1974 May;7:155–159. doi: 10.1289/ehp.747155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Allen J. R., McWey P. J., Suomi S. J. Pathobiological and behavioral effects of lead intoxication in the infant rhesus monkey. Environ Health Perspect. 1974 May;7:239–246. doi: 10.1289/ehp.747239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anderson C., Danylchuk K. D. The effect of chronic low level lead intoxication on the Haversian remodeling system in dogs. Lab Invest. 1977 Nov;37(5):466–469. [PubMed] [Google Scholar]
  4. Barltrop D. Lead poisoning in childhood. Postgrad Med J. 1968 Jul;44(513):537–542. doi: 10.1136/pgmj.44.513.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Betts P. R., Astley R., Raine D. N. Lead intoxication in children in Birmingham. Br Med J. 1973 Feb 17;1(5850):402–406. doi: 10.1136/bmj.1.5850.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bull R. J., Stanaszek P. M., O'Neill J. J., Lutkenhoff S. D. Specificity of the effects of lead on brain energy metabolism for substrates donating a cytoplasmic reducing equivalent. Environ Health Perspect. 1975 Dec;12:89–95. doi: 10.1289/ehp.751289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chisolm J. J. Current status of lead exposure and poisoning in children. South Med J. 1976 May;69(5):529–531. doi: 10.1097/00007611-197605000-00001. [DOI] [PubMed] [Google Scholar]
  8. Chisolm J. J., Jr, Mellits E. D., Keil J. E., Barrett M. B. Variations in hematologic responses to increased lead absorption in young children. Environ Health Perspect. 1974 May;7:7–12. doi: 10.1289/ehp.7477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Davis J. R., Andelman S. L. Urinary delta-aminolevulinic acid (ALA) levels in lead poisoning. I. A modified method for the rapid determination of urinary delta-aminolevulinic acid using disposable ion-exchange chromatography columns. Arch Environ Health. 1967 Jul;15(1):53–59. doi: 10.1080/00039896.1967.10664873. [DOI] [PubMed] [Google Scholar]
  10. Forbes G. B., Reina J. C. Effect of age on gastrointestinal absorption (Fe, Sr, Pb) in the rat. J Nutr. 1972 May;102(5):647–652. doi: 10.1093/jn/102.5.647. [DOI] [PubMed] [Google Scholar]
  11. Gibson S. L., Goldberg A. Defects in haem synthesis in mammalian tissues in experimental lead poisoning and experimental porphyria. Clin Sci. 1970 Jan;38(1):63–72. doi: 10.1042/cs0380063. [DOI] [PubMed] [Google Scholar]
  12. Goldstein G. W., Asbury A. K., Diamond I. Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries. Arch Neurol. 1974 Dec;31(6):382–389. doi: 10.1001/archneur.1974.00490420048005. [DOI] [PubMed] [Google Scholar]
  13. Goyer R. A., Leonard D. L., Moore J. F., Rhyne B., Krigman M. R. Lead dosage and the role of the intranuclear inclusion body. An experimental study. Arch Environ Health. 1970 Jun;20(6):705–711. doi: 10.1080/00039896.1970.10665647. [DOI] [PubMed] [Google Scholar]
  14. Goyer R. A., Rhyne B. C. Pathological effects of lead. Int Rev Exp Pathol. 1973;12:1–77. [PubMed] [Google Scholar]
  15. Kostial K., Simonović I., Pisonić M. Lead absorption from the intestine in newborn rats. Nature. 1971 Oct 22;233(5321):564–564. doi: 10.1038/233564a0. [DOI] [PubMed] [Google Scholar]
  16. Lin-Fu J. S. Vulnerability of children to lead exposure and toxicity (first of two parts). N Engl J Med. 1973 Dec 6;289(23):1229–1233. doi: 10.1056/NEJM197312062892306. [DOI] [PubMed] [Google Scholar]
  17. Mahaffey K. R., Rader J. I., Schaefer J. M., Kramer S. N. Comparative toxicity to rats of lead acetate from food or water. Bull Environ Contam Toxicol. 1980 Oct;25(4):541–546. doi: 10.1007/BF01985569. [DOI] [PubMed] [Google Scholar]
  18. McCabe E. B. Age and sensitivity to lead toxicity: a review. Environ Health Perspect. 1979 Apr;29:29–33. doi: 10.1289/ehp.792929. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Michaelson I. A., Sauerhoff M. W. Animal models of human disease: severe and mild lead encephalopathy in the neonatal rat. Environ Health Perspect. 1974 May;7:201–225. doi: 10.1289/ehp.747201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Momcilović B., Kostial K. Kinetics of lead retention and distribution in suckling and adult rats. Environ Res. 1974 Oct;8(2):214–220. doi: 10.1016/0013-9351(74)90053-x. [DOI] [PubMed] [Google Scholar]
  21. Mykkanen H. M., Dickerson J. W., Lancaster M. C. Effect of age on the tissue distribution of lead in the rat. Toxicol Appl Pharmacol. 1979 Dec;51(3):447–454. doi: 10.1016/0041-008x(79)90369-7. [DOI] [PubMed] [Google Scholar]
  22. Mylroie A. A., Moore L., Erogbogbo U. Influence of dietary factors on blood and tissue lead concentrations and lead toxicity. Toxicol Appl Pharmacol. 1977 Aug;41(2):361–367. doi: 10.1016/0041-008x(77)90037-0. [DOI] [PubMed] [Google Scholar]
  23. Needleman H. L., Gunnoe C., Leviton A., Reed R., Peresie H., Maher C., Barrett P. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med. 1979 Mar 29;300(13):689–695. doi: 10.1056/NEJM197903293001301. [DOI] [PubMed] [Google Scholar]
  24. Pentschew A., Garro F. Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases. With special reference to the permeability disorders of the nervous system's capillaries. Acta Neuropathol. 1966 Jun 1;6(3):266–278. doi: 10.1007/BF00687857. [DOI] [PubMed] [Google Scholar]
  25. Piomelli S. Free erythrocyte porphyrins in the detection of undue absorption of Pb and of Fe deficiency. Clin Chem. 1977 Feb;23(2 Pt 1):264–269. [PubMed] [Google Scholar]
  26. Repko J. D., Corum C. R. Critical review and evaluation of the neurological and behavioral sequelae of inorganic lead absorption. CRC Crit Rev Toxicol. 1979 Jan;6(2):135–187. doi: 10.3109/10408447909113048. [DOI] [PubMed] [Google Scholar]
  27. Rosenblum W. I., Johnson M. G. Neuropathologic changes produced in suckling mice by adding lead to the maternal diet. Arch Pathol. 1968 Jun;85(6):640–648. [PubMed] [Google Scholar]
  28. Savolainen H., Kilpiö J. Brain and blood lead in acute intoxication. Scand J Work Environ Health. 1977 Jun;3(2):104–107. doi: 10.5271/sjweh.2788. [DOI] [PubMed] [Google Scholar]
  29. Waldron H. A. Subclinical lead poisoning: a preventable disease. Prev Med. 1975 Jun;4(2):135–153. doi: 10.1016/0091-7435(75)90079-1. [DOI] [PubMed] [Google Scholar]
  30. Willes R. F., Lok E., Truelove J. F., Sundaram A. Retention and tissue distribution of 210Pb (NO3)2 administered orally to infant and adult monkeys. J Toxicol Environ Health. 1977 Oct;3(3):395–406. doi: 10.1080/15287397709529572. [DOI] [PubMed] [Google Scholar]
  31. Ziegler E. E., Edwards B. B., Jensen R. L., Mahaffey K. R., Fomon S. J. Absorption and retention of lead by infants. Pediatr Res. 1978 Jan;12(1):29–34. doi: 10.1203/00006450-197801000-00008. [DOI] [PubMed] [Google Scholar]
  32. Zook B. C., London W. T., Sever J. L., Sauer R. M. Experimental lead paint poisoning in nonhuman primates. I. Clinical signs and course. J Med Primatol. 1976;5(1):23–40. doi: 10.1159/000459904. [DOI] [PubMed] [Google Scholar]

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