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. 1981 Oct;41:189–193. doi: 10.1289/ehp.8141189

Mutagenicity studies of vinyl chloride.

J D Fabricant, M S Legator
PMCID: PMC1568839  PMID: 7333237

Abstract

Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbin A., Brésil H., Croisy A., Jacquignon P., Malaveille C., Montesano R., Bartsch H. Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride. Biochem Biophys Res Commun. 1975 Nov 17;67(2):596–603. doi: 10.1016/0006-291x(75)90854-2. [DOI] [PubMed] [Google Scholar]
  2. Carr D. H. Chromosome anomalies as a cause of spontaneous abortion. Am J Obstet Gynecol. 1967 Feb 1;97(3):283–293. doi: 10.1016/0002-9378(67)90488-7. [DOI] [PubMed] [Google Scholar]
  3. Drozdowicz B. Z., Huang P. C. Lack of mutagenicity of vinyl chloride in two strains of Neurospora crassa. Mutat Res. 1977;48(1):43–50. doi: 10.1016/0027-5107(77)90189-0. [DOI] [PubMed] [Google Scholar]
  4. Ducatman A., Hirschhorn K., Selikoff I. J. Vinyl chloride exposure and human chromosome aberrations. Mutat Res. 1975 Jun;31(3):163–168. doi: 10.1016/0165-1161(75)90085-0. [DOI] [PubMed] [Google Scholar]
  5. Greim H., Bonse G., Radwan Z., Reichert D., Henschler D. Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation. Biochem Pharmacol. 1975 Nov 1;24(21):2013–2017. doi: 10.1016/0006-2952(75)90396-2. [DOI] [PubMed] [Google Scholar]
  6. Hansteen I. L., Hillestad L., Thiis-Evensen E., Heldaas S. S. Effects of vinyl chloride in man: a cytogenetic follow-up study. Mutat Res. 1978 Aug;51(2):271–278. doi: 10.1016/s0027-5107(78)80022-0. [DOI] [PubMed] [Google Scholar]
  7. Heath C. W., Jr, Dumont C. R. Chromosomal damage in men occupationally exposed to vinyl chloride monomer and other chemicals. Environ Res. 1977 Aug;14(1):68–72. doi: 10.1016/0013-9351(77)90067-6. [DOI] [PubMed] [Google Scholar]
  8. Infante P. F., Wagoner J. K., Waxweiler R. J. Carcinogenic, mutagenic and teratogenic risks associated with vinyl chloride. Mutat Res. 1976 Nov 1;41(1 SPEL):131–141. doi: 10.1016/0027-5107(76)90083-x. [DOI] [PubMed] [Google Scholar]
  9. Kucerová M. Cytogenetic analysis of human chromosomes and its value for the estimation of genetic risk. Mutat Res. 1976 Nov 1;41(1 SPEL):123–130. doi: 10.1016/0027-5107(76)90082-8. [DOI] [PubMed] [Google Scholar]
  10. Magnusson J., Ramel C. Mutagenic effects of vinyl chloride on Drosophila melanogaster with and without pretreatment with sodium phenobarbiturate. Mutat Res. 1978 Jul;57(3):307–312. doi: 10.1016/0027-5107(78)90215-4. [DOI] [PubMed] [Google Scholar]
  11. McCann J., Simmon V., Streitwieser D., Ames B. N. Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3190–3193. doi: 10.1073/pnas.72.8.3190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Purchase I. F., Richardson C. R., Anderson D., Paddle G. M., Adams W. G. Chromosomal analyses in vinyl chloride-exposed workers. Mutat Res. 1978 Jul;57(3):325–334. doi: 10.1016/0027-5107(78)90217-8. [DOI] [PubMed] [Google Scholar]
  13. Rannug U., Göthe R., Wachtmeister C. A. The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride. Chem Biol Interact. 1976 Mar;12(3-4):251–263. doi: 10.1016/0009-2797(76)90041-7. [DOI] [PubMed] [Google Scholar]
  14. Shahin M. The non-mutagenicity and -recombinogenicity of vinyl chloride in the absence of metabolic activation. Mutat Res. 1976 Jul;40(3):269–272. doi: 10.1016/0165-1218(76)90053-7. [DOI] [PubMed] [Google Scholar]
  15. Short R. D., Minor J. L., Winston J. M., Lee C. C. A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride. J Toxicol Environ Health. 1977 Dec;3(5-6):965–968. doi: 10.1080/15287397709529630. [DOI] [PubMed] [Google Scholar]
  16. Speck W. T., Santella R. M., Rosenkranz H. S. An evaluation of the prophage lambda induction (inductest) for the detection of potential carcinogens. Mutat Res. 1978 Aug;54(1):101–104. doi: 10.1016/0165-1161(78)90140-1. [DOI] [PubMed] [Google Scholar]
  17. Szentesi I., Hornyák E., Ungváry G., Czeizel A., Bognár Z., Timar M. High rate of chromosomal aberration in PVC workers. Mutat Res. 1976 Nov;37(2-3):313–316. doi: 10.1016/0027-5107(76)90045-2. [DOI] [PubMed] [Google Scholar]
  18. de Meester C., Duverger-van Bogaert M., Lambotte-Vandepaer M., Roberfroid M., Poncelet F., Mercier M. Mutagenicity of vinyl chloride in the Ames test: possible artifacts related to experimental conditions. Mutat Res. 1980 Feb;77(2):175–179. doi: 10.1016/0165-1218(80)90135-4. [DOI] [PubMed] [Google Scholar]

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