Abstract
Concern has recently been voiced over possible chronic toxicity associated with chlorination of public drinking water supplies in the United States. This paper reviews the available evidence and the studies underway to further evaluate hypothesized associations between cancer risk and byproducts of chlorination. Preliminary data from measures of halogenated volatiles and personal exposure histories from respondents in a large epidemiologic study of bladder cancer are presented. These data support the use in epidemiologic studies of categorical measures of exposure and suggest that results from completed case-control studies, based on death certificates, may have underestimated the true risk of exposure to chlorination by-products. The current generation of studies which use a case-control interview design offer many advantages over earlier efforts to evaluate this issue.
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Selected References
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- Cantor K. P., Hoover R., Mason T. J., McCabe L. J. Associations of cancer mortality with halomethanes in drinking water. J Natl Cancer Inst. 1978 Oct;61(4):979–985. [PubMed] [Google Scholar]
- Hoover R. N., Strasser P. H. Artificial sweeteners and human bladder cancer. Preliminary results. Lancet. 1980 Apr 19;1(8173):837–840. doi: 10.1016/s0140-6736(80)91350-1. [DOI] [PubMed] [Google Scholar]
- Page T., Harris R. H., Epstein S. S. Drinking water and cancer mortality in Louisiana. Science. 1976 Jul 2;193(4247):55–57. doi: 10.1126/science.935854. [DOI] [PubMed] [Google Scholar]
- Wilkins J. R., 3rd, Reiches N. A., Kruse C. W. Organic chemical contaminants in drinking water and cancer. Am J Epidemiol. 1979 Oct;110(4):420–448. doi: 10.1093/oxfordjournals.aje.a112825. [DOI] [PubMed] [Google Scholar]
- Young T. B., Kanarek M. S., Tsiatis A. A. Epidemiologic study of drinking water chlorination and Wisconsin female cancer mortality. J Natl Cancer Inst. 1981 Dec;67(6):1191–1198. [PubMed] [Google Scholar]