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. 1983 Mar;49:13–19. doi: 10.1289/ehp.834913

Historical and modern epidemiological studies on populations exposed to N-substituted aryl compounds.

R A Cartwright
PMCID: PMC1569142  PMID: 6339220

Abstract

The historical exposures to aromatic amines of various occupational groups are briefly reviewed. Modern studies indicate that other occupational groups might have risks worth investigating; these include machinists and workers in the chemical industry. Details of a recent investigation into the exposure of dye workers are given which indicate a lowered risk in recent years since the introduction of safety measures. Nonoccupational exposures to the aromatic amines are also discussed. They include cigarette smoking and phenacetin abuse, the former being a potent causal agent in bladder cancer.

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Selected References

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  1. CASE R. A., HOSKER M. E. Tumour of the urinary bladder as an occupational disease in the rubber industry in England and Wales. Br J Prev Soc Med. 1954 Apr;8(2):39–50. doi: 10.1136/jech.8.2.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CASE R. A., PEARSON J. T. Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. II. Further consideration of the role of aniline and of the manufacture of auramine and magenta (fuchsine) as possible causative agents. Br J Ind Med. 1954 Jul;11(3):213–216. doi: 10.1136/oem.11.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CASE R. A. The expected frequency of bladder tumour in works populations. Br J Ind Med. 1953 Apr;10(2):114–120. doi: 10.1136/oem.10.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cartwright R. A., Glashan R. W., Gray B. Survival of transitional cell carcinoma cases in 2 Yorkshire centres. Br J Urol. 1980 Dec;52(6):497–499. doi: 10.1111/j.1464-410x.1980.tb03099.x. [DOI] [PubMed] [Google Scholar]
  5. Case R. A. Tumours of the urinary tract as an occupational disease in several industries. Ann R Coll Surg Engl. 1966 Oct;39(4):213–235. [PMC free article] [PubMed] [Google Scholar]
  6. Cole P., Hoover R., Friedell G. H. Occupation and cancer of the lower urinary tract. Cancer. 1972 May;29(5):1250–1260. doi: 10.1002/1097-0142(197205)29:5<1250::aid-cncr2820290518>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  7. DAVIES J. M. BLADDER TUMOURS IN THE ELECTRIC-CABLE INDUSTRY. Lancet. 1965 Jul 24;2(7404):143–146. doi: 10.1016/s0140-6736(65)90228-x. [DOI] [PubMed] [Google Scholar]
  8. DOLL R., FISHER R. E., GAMMON E. J., GUNN W., HUGHES G. O., TYRER F. H., WILSON W. MORTALITY OF GASWORKERS WITH SPECIAL REFERENCE TO CANCERS OF THE LUNG AND BLADDER, CHRONIC BRONCHITIS, AND PNEUMOCONIOSIS. Br J Ind Med. 1965 Jan;22:1–12. doi: 10.1136/oem.22.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dunham L. J., Rabson A. S., Stewart H. L., Frank A. S., Young J. L. Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana. J Natl Cancer Inst. 1968 Sep;41(3):683–709. [PubMed] [Google Scholar]
  10. Fokkens W. Phenacetin abuse related to bladder cancer. Environ Res. 1979 Oct;20(1):192–198. doi: 10.1016/0013-9351(79)90097-5. [DOI] [PubMed] [Google Scholar]
  11. Fox A. J., Collier P. F. A survey of occupational cancer in the rubber and cablemaking industries: analysis of deaths occurring in 1972-74. Br J Ind Med. 1976 Nov;33(4):249–264. doi: 10.1136/oem.33.4.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Garner R. C., Nutman C. A. Testing of some azo dyes and their reduction products for mutagenicity using Salmonella typhimurium TA 1538. Mutat Res. 1977 Jul;44(1):9–19. doi: 10.1016/0027-5107(77)90110-5. [DOI] [PubMed] [Google Scholar]
  13. Goldwater L. J., Rosso A. J., Kleinfeld M. Bladder tumors in a coal tar dye plant. Arch Environ Health. 1965 Dec;11(6):814–817. doi: 10.1080/00039896.1965.10664306. [DOI] [PubMed] [Google Scholar]
  14. Howe G. R., Burch J. D., Miller A. B., Cook G. M., Esteve J., Morrison B., Gordon P., Chambers L. W., Fodor G., Winsor G. M. Tobacco use, occupation, coffee, various nutrients, and bladder cancer. J Natl Cancer Inst. 1980 Apr;64(4):701–713. [PubMed] [Google Scholar]
  15. Johansson S., Wahlqvist L. Tumours of urinary bladder and ureter associated with abuse of phenacetin-containing analgesics. Acta Pathol Microbiol Scand A. 1977 Nov;85(6):768–774. doi: 10.1111/j.1699-0463.1977.tb03892.x. [DOI] [PubMed] [Google Scholar]
  16. MELICK W. F., ESCUE H. M., NARYKA J. J., MEZERA R. A., WHEELER E. P. The first reported cases of human bladder tumors due to a new carcinogen-xenylamine. J Urol. 1955 Dec;74(6):760–766. doi: 10.1016/S0022-5347(17)67344-0. [DOI] [PubMed] [Google Scholar]
  17. Mancuso T. F., el-Attar A. A. Cohort study of workers exposed to betanaphthylamine and benzidine. J Occup Med. 1967 Jun;9(6):277–285. [PubMed] [Google Scholar]
  18. Melick W. F., Naryka J. J., Kelly R. E. Bladder cancer due to exposure to para-aminobiphenyl: a 17-year followup. J Urol. 1971 Aug;106(2):220–226. doi: 10.1016/s0022-5347(17)61263-1. [DOI] [PubMed] [Google Scholar]
  19. THIEDE T., CHIEVITZ E., CHRISTENSEN B. C. CHLORNAPHAZINE AS A BLADDER CARCINOGEN. Acta Med Scand. 1964 Jun;175:721–725. doi: 10.1111/j.0954-6820.1964.tb00628.x. [DOI] [PubMed] [Google Scholar]
  20. Thiede T., Christensen B. C. Bladder tumours induced by chlornaphazine. A five-year follow-up study of chlornaphazine-treated patients with polycythaemia. Acta Med Scand. 1969 Jan-Feb;185(1-2):133–137. [PubMed] [Google Scholar]
  21. Thériault G., De Guire L., Cordier S. Reducing aluminum: an occupation possibly associated with bladder cancer. Can Med Assoc J. 1981 Feb 15;124(4):419-22, 425. [PMC free article] [PubMed] [Google Scholar]
  22. Tyrrell A. B., MacAirt J. G., McCaughey W. T. Occupational and non-occupational factors associated with vesical neoplasm in Ireland. J Ir Med Assoc. 1971 Apr 22;64(410):213–217. [PubMed] [Google Scholar]
  23. UEBELIN F., PLETSCHER A. Atiologie und Prophylaxe gewerblicher Tumoren in der Farbstoffindustrie. Schweiz Med Wochenschr. 1954 Aug 7;84(32):917–920. [PubMed] [Google Scholar]
  24. VIDEBAEK A. CHLORNAPHAZIN (ERYSAN) MAY INDUCE CANCER OF THE URINARY BLADDER. Acta Med Scand. 1964 Jul;176:45–50. [PubMed] [Google Scholar]
  25. WYNDER E. L., ONDERDONK J., MANTEL N. AN EPIDEMIOLOGICAL INVESTIGATION OF CANCER OF THE BLADDER. Cancer. 1963 Nov;16:1388–1407. doi: 10.1002/1097-0142(196311)16:11<1388::aid-cncr2820161104>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  26. Wynder E. L., Goldsmith R. The epidemiology of bladder cancer: a second look. Cancer. 1977 Sep;40(3):1246–1268. doi: 10.1002/1097-0142(197709)40:3<1246::aid-cncr2820400340>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]

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