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. 1983 Sep;51:281–285. doi: 10.1289/ehp.8351281

Asbestos fibers, plasma and inflammation.

J A Hamilton
PMCID: PMC1569261  PMID: 6641659

Abstract

Fibrin clots have been detected at sites of inflammation, and kinins have been implicated as mediators of the vascular phenomena of acute inflammation, systemic shock, and disseminated intravascular coagulation. It is now reported that both negatively and positively charged asbestos fibers shorten the partial thromboplastin time of human plasma, indicating coagulation of the plasma. A sample containing short (less than 5 micron in length) chrysotile fibers is ineffective. Only the negatively charged amphiboles (crocidolite and amosite) are able to activate factor XII (Hageman factor). This particular effect of the amphiboles is enhanced by high molecular weight kininogen and leads to kinin formation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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