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. 1997 Mar;9(3):425–439. doi: 10.1105/tpc.9.3.425

The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B.

J Ryals 1, K Weymann 1, K Lawton 1, L Friedrich 1, D Ellis 1, H Y Steiner 1, J Johnson 1, T P Delaney 1, T Jesse 1, P Vos 1, S Uknes 1
PMCID: PMC156928  PMID: 9090885

Abstract

The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor I kappa B subclass alpha. NF-kappa B/I kappa B signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

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Selected References

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