Abstract
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AMES B. N., DUBIN D. T. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem. 1960 Mar;235:769–775. [PubMed] [Google Scholar]
- Cohn Z. A. Activation of mononuclear phagocytes: fact, fancy, and future. J Immunol. 1978 Sep;121(3):813–816. [PubMed] [Google Scholar]
- Davies P., Allison A. C., Ackerman J., Butterfield A., Williams S. Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature. 1974 Oct 4;251(5474):423–425. doi: 10.1038/251423a0. [DOI] [PubMed] [Google Scholar]
- Donaldson K., Davis J. M., James K. Characteristics of peritoneal macrophages induced by asbestos injection. Environ Res. 1982 Dec;29(2):414–424. doi: 10.1016/0013-9351(82)90042-1. [DOI] [PubMed] [Google Scholar]
- Donaldson K., Davis J. M., James K. Concanavalin A receptors and capping in control and activated macrophages. Histochem J. 1983 Jan;15(1):59–69. doi: 10.1007/BF01006071. [DOI] [PubMed] [Google Scholar]
- Hamilton J. A. Macrophage stimulation and the inflammatory response to asbestos. Environ Health Perspect. 1980 Feb;34:69–74. doi: 10.1289/ehp.803469. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hamilton J., Vassalli J. D., Reich E. Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids. J Exp Med. 1976 Dec 1;144(6):1689–1694. doi: 10.1084/jem.144.6.1689. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Humes J. L., Bonney R. J., Pelus L., Dahlgren M. E., Sadowski S. J., Kuehl F. A., Jr, Davies P. Macrophages synthesis and release prostaglandins in response to inflammatory stimuli. Nature. 1977 Sep 8;269(5624):149–151. doi: 10.1038/269149a0. [DOI] [PubMed] [Google Scholar]
- Keller R., Keist R., Hecker E. Tumour-promoting diterpene esters prevent macrophage activation. Br J Cancer. 1982 Jan;45(1):144–146. doi: 10.1038/bjc.1982.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Miller K., Kagan E. Manifestations of cellular immunity in the rat after prolonged asbestos inhalation. II. Alveolar macrophage-induced splenic lymphocyte proliferation. Environ Res. 1981 Oct;26(1):182–194. doi: 10.1016/0013-9351(81)90197-3. [DOI] [PubMed] [Google Scholar]
- Raz A., Shahar A., Goldman R. Characterization of an in vivo induced peritoneal macrophage population following intraperitoneal injection of concanavalin A. J Reticuloendothel Soc. 1977 Nov;22(5):445–460. [PubMed] [Google Scholar]
- Sirois P., Rola-Pleszczynski M., Bégin R. Phospholipase A activity and prostaglandin release from alveolar macrophages exposed to asbestos. Prostaglandins Med. 1980 Jul;5(1):31–37. doi: 10.1016/0161-4630(80)90088-9. [DOI] [PubMed] [Google Scholar]
- Topping D. C., Nettesheim P. Two-stage carcinogenesis studies with asbestos in Fischer 344 rats. J Natl Cancer Inst. 1980 Sep;65(3):627–630. [PubMed] [Google Scholar]
- Woodruff M. F., Inchley M. P., Dunbar N. Further observations on the effect of C. parvum and anti-tumour globulin on syngeneically transplanted mouse tumours. Br J Cancer. 1972 Apr;26(2):67–76. doi: 10.1038/bjc.1972.11. [DOI] [PMC free article] [PubMed] [Google Scholar]