Abstract
Carbon monoxide is widely distributed in the environment, and acute or chronic toxic effects may be of considerable public health significance. A review of the basis for current ambient standards is given. Mortality and morbidity studies have been negative or equivocal in relating carbon monoxide levels to health effects, but studies in human subjects with compromised coronary or peripheral circulation support an effect of acute exposure to CO at blood levels equivalent to about 20 ppm over several hours. It is possible that some of the cardiovascular effects of smoking may be related to the high levels of CO in cigarette smoke, but it has been difficult to isolate the contribution of CO independent of the effects of other smoke constituents.
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Selected References
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- Aronow W. S., Charter R., Seacat G. Effect of 4% carboxyhemoglobin on human performance in cardiac patients. Prev Med. 1979 Sep;8(5):562–566. doi: 10.1016/0091-7435(79)90332-3. [DOI] [PubMed] [Google Scholar]
- Aronow W. S. Effect of passive smoking on angina pectoris. N Engl J Med. 1978 Jul 6;299(1):21–24. doi: 10.1056/NEJM197807062990105. [DOI] [PubMed] [Google Scholar]
- Aronow W. S., Ferlinz J., Glauser F. Effect of carbon monoxide on exercise performance in chronic obstructive pulmonary disease. Am J Med. 1977 Dec;63(6):904–908. doi: 10.1016/0002-9343(77)90544-7. [DOI] [PubMed] [Google Scholar]
- Aronow W. S., Stemmer E. A., Isbell M. W. Effect of carbon monoxide exposure on intermittent claudication. Circulation. 1974 Mar;49(3):415–417. doi: 10.1161/01.cir.49.3.415. [DOI] [PubMed] [Google Scholar]
- Aronow W. S., Stemmer E. A., Zweig S. Carbon monoxide and ventricular fibrillation threshold in normal dogs. Arch Environ Health. 1979 May-Jun;34(3):184–186. doi: 10.1080/00039896.1979.10667394. [DOI] [PubMed] [Google Scholar]
- CURPHEY T. J., HOOD L. P., PERKINS N. M. CARBOXYHEMOGLOBIN IN RELATION TO AIR POLLUTION AND SMOKING: POSTMORTEM STUDIES. Arch Environ Health. 1965 Feb;10:179–185. doi: 10.1080/00039896.1965.10663980. [DOI] [PubMed] [Google Scholar]
- Cohen S. I., Deane M., Goldsmith J. R. Carbon monoxide and survival from myocardial infarction. Arch Environ Health. 1969 Oct;19(4):510–517. doi: 10.1080/00039896.1969.10666877. [DOI] [PubMed] [Google Scholar]
- Davies D. M., Smith D. J. Electrocardiographic changes in healthy men during continuous low-level carbon monoxide exposure. Environ Res. 1980 Feb;21(1):197–206. doi: 10.1016/0013-9351(80)90022-5. [DOI] [PubMed] [Google Scholar]
- DeBias D. A., Banerjee C. M., Birkhead N. C., Greene C. H., Scott S. D., Harrer W. V. Effects of carbon monoxide inhalation on ventricular fibrillation. Arch Environ Health. 1976 Jan-Feb;31(1):42–46. doi: 10.1080/00039896.1976.10667188. [DOI] [PubMed] [Google Scholar]
- Hirayama T. Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study from Japan. Br Med J (Clin Res Ed) 1981 Jan 17;282(6259):183–185. doi: 10.1136/bmj.282.6259.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones J. G., Sinclair A. Arterial disease amongst blast furnace workers. Ann Occup Hyg. 1975 Aug;18(1):15–20. doi: 10.1093/annhyg/18.1.15. [DOI] [PubMed] [Google Scholar]
- Koskela R. S., Hernberg S., Kärävä R., Järvinen E., Nurminen M. A mortality study of foundry workers. Scand J Work Environ Health. 1976;2 (Suppl 1):73–89. doi: 10.5271/sjweh.2829. [DOI] [PubMed] [Google Scholar]
- Kuller L. H., Radford E. P., Swift D., Perper J. A., Fisher R. Carbon monoxide and heart attacks. Arch Environ Health. 1975 Oct;30(10):477–482. doi: 10.1080/00039896.1975.10666757. [DOI] [PubMed] [Google Scholar]
- Kurt T. L., Mogielnicki R. P., Chandler J. E. Association of the frequency of acute cardiorespiratory complaints with ambient levels of carbon monoxide. Chest. 1978 Jul;74(1):10–14. doi: 10.1378/chest.74.1.10. [DOI] [PubMed] [Google Scholar]
- Meyer M. B., Tonascia J. A., Buck C. The interrelationship of maternal smoking and increased perinatal mortality with other risk factors. Further analysis of the Ontario Perinatal Mortality Study, 1960-1961. Am J Epidemiol. 1974 Dec;100(6):443–452. doi: 10.1093/oxfordjournals.aje.a112056. [DOI] [PubMed] [Google Scholar]
- Redmond C. K., Emes J. J., Mazumdar S., Magee P. C., Kamon E. Mortality of steelworkers employed in hot jobs. J Environ Pathol Toxicol. 1979 May-Jun;2(5):75–96. [PubMed] [Google Scholar]
- Silk S. J. The threshold limit value for carbon monoxide. Ann Occup Hyg. 1975 Aug;18(1):29–35. doi: 10.1093/annhyg/18.1.29. [DOI] [PubMed] [Google Scholar]
- Stewart R. D., Baretta E. D., Platte L. R., Stewart E. B., Kalbfleisch J. H., Van Yserloo B., Rimm A. A. Carboxyhemoglobin levels in American blood donors. JAMA. 1974 Aug 26;229(9):1187–1195. [PubMed] [Google Scholar]
- Wallace N. D., Davis G. L., Rutledge R. B., Kahn A. Smoking and carboxyhemoglobin in the St. Louis metropolitan population: theoretical and empirical considerations. Arch Environ Health. 1974 Sep;29(3):136–142. doi: 10.1080/00039896.1974.10666550. [DOI] [PubMed] [Google Scholar]
