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. 1983 Oct;52:165–168. doi: 10.1289/ehp.8352165

Air pollutants and the facilitation of cancer metastasis.

A Richters, K Kuraitis
PMCID: PMC1569355  PMID: 6653518

Abstract

Studies have been carried out to determine whether the inhalation of ambient levels of nitrogen dioxide (NO2), a common air pollutant, could influence the frequency of blood-borne cancer cell metastasis to the lungs. B16 mouse melanoma cells were used as an in vivo test model. the results have indicated that animals inhaling ambient levels of NO2 developed a significantly higher number of melanoma nodules in their lungs than the animals inhaling filtered air. Thus, a new concept for the action of air pollutants is proposed. The question is raised whether similar events are taking place in urban human populations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames B. N. Identifying environmental chemicals causing mutations and cancer. Science. 1979 May 11;204(4393):587–593. doi: 10.1126/science.373122. [DOI] [PubMed] [Google Scholar]
  2. Bils R. F., Christie B. R. The experimental pathology of oxidant and air pollutant inhalation. Int Rev Exp Pathol. 1980;21:195–293. [PubMed] [Google Scholar]
  3. Butler T. P., Gullino P. M. Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res. 1975 Mar;35(3):512–516. [PubMed] [Google Scholar]
  4. CANDAR Z., RITCHIE A. C., HOPKIRK J. F., LONG R. C. The prognostic value of circulating tumor cells in patients with breast cancer. Surg Gynecol Obstet. 1962 Sep;115:291–294. [PubMed] [Google Scholar]
  5. Chalmer J., Holt P. G., Keast D. Cell-mediated immune responses to transplanted tumors in mice chronically exposed to cigarette smoke. J Natl Cancer Inst. 1975 Nov;55(5):1129–1134. doi: 10.1093/jnci/55.5.1129. [DOI] [PubMed] [Google Scholar]
  6. Dawson S. V., Schenker M. B. Health effects of inhalation of ambient concentrations of nitrogen dioxide. Am Rev Respir Dis. 1979 Aug;120(2):281–292. doi: 10.1164/arrd.1979.120.2.281. [DOI] [PubMed] [Google Scholar]
  7. Fisher E. R., Fisher B. Circulating cancer cells and metastases. Int J Radiat Oncol Biol Phys. 1975 Oct-Nov;1(1-2):87–91. doi: 10.1016/0360-3016(75)90014-0. [DOI] [PubMed] [Google Scholar]
  8. Ford A. B., Bialik O. Air pollution and urban factors in relation to cancer mortality. Arch Environ Health. 1980 Nov-Dec;35(6):350–359. doi: 10.1080/00039896.1980.10667519. [DOI] [PubMed] [Google Scholar]
  9. Goldsmith J. R. The "urban factor" in cancer: smoking, industrial exposures, and air pollution as possible explanations. J Environ Pathol Toxicol. 1980 Mar;3(4 Spec No):205–217. [PubMed] [Google Scholar]
  10. Guidotti T. L. The higher oxides of nitrogen: inhalation toxicology. Environ Res. 1978 Jun;15(3):443–472. doi: 10.1016/0013-9351(78)90125-1. [DOI] [PubMed] [Google Scholar]
  11. Hammond E. C., Garfinkel L. General air pollution and cancer in the United States. Prev Med. 1980 Mar;9(2):206–211. doi: 10.1016/0091-7435(80)90077-8. [DOI] [PubMed] [Google Scholar]
  12. Holt P. G., Finlay-Jones L. M., Keast D., Papadimitrou J. M. Immunological function in mice chronically exposed to nitrogen oxides (NOx). Environ Res. 1979 Jun;19(1):154–162. doi: 10.1016/0013-9351(79)90043-4. [DOI] [PubMed] [Google Scholar]
  13. Hughes T. J., Pellizzari E., Little L., Sparacino C., Kolber A. Ambient air pollutants: collection, chemical characterization and mutagenicity testing. Mutat Res. 1980 Jul;76(1):51–83. doi: 10.1016/0165-1110(80)90003-2. [DOI] [PubMed] [Google Scholar]
  14. Illing J. W., Miller F. J., Gardner D. E. Decreased resistance to infection in exercised mice exposed to NO2 and O3. J Toxicol Environ Health. 1980 Jul;6(4):843–851. doi: 10.1080/15287398009529902. [DOI] [PubMed] [Google Scholar]
  15. Kuraitis K. V., Richters A., Sherwin R. P. Spleen changes in animals inhaling ambient levels of nitrogen dioxide. J Toxicol Environ Health. 1981 Jun;7(6):851–859. doi: 10.1080/15287398109530028. [DOI] [PubMed] [Google Scholar]
  16. Poste G., Fidler I. J. The pathogenesis of cancer metastasis. Nature. 1980 Jan 10;283(5743):139–146. doi: 10.1038/283139a0. [DOI] [PubMed] [Google Scholar]
  17. Richters A. Facilitation of cancer metastases by an air pollutant. J Surg Oncol. 1981;17(2):159–162. doi: 10.1002/jso.2930170210. [DOI] [PubMed] [Google Scholar]
  18. Sherwin R. P. Pathogenesis of metastasis formation. Int J Radiat Oncol Biol Phys. 1975 Oct-Nov;1(1-2):101–105. doi: 10.1016/0360-3016(75)90017-6. [DOI] [PubMed] [Google Scholar]
  19. Sherwin R. P., Richters V. Lung capillary permeability. Nitrogen dioxide exposure and leakage of tritiated serum. Arch Intern Med. 1971 Jul;128(1):61–68. doi: 10.1001/archinte.128.1.61. [DOI] [PubMed] [Google Scholar]
  20. Sherwin R. P., Yuen T. G. Silicone fluid for the metering and monitoring of nitrogen dioxide. Arch Environ Health. 1972 May;24(5):331–336. doi: 10.1080/00039896.1972.10666100. [DOI] [PubMed] [Google Scholar]
  21. Silverberg E. Cancer statistics, 1981. CA Cancer J Clin. 1981 Jan-Feb;31(1):13–28. doi: 10.3322/canjclin.31.1.13. [DOI] [PubMed] [Google Scholar]
  22. Song J., From P., Morrissey W. J., Sams J. Circulating cancer cells: pre- and post-chemotherapy observations. Cancer. 1971 Sep;28(3):553–561. doi: 10.1002/1097-0142(197109)28:3<553::aid-cncr2820280304>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  23. Stjernsward J. Can survival be decreased by post-operative irradiation. Int J Radiat Oncol Biol Phys. 1977 Nov-Dec;2(11-12):1171–1175. doi: 10.1016/0360-3016(77)90128-6. [DOI] [PubMed] [Google Scholar]

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