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. 1961 Jun;94(6):344–349.

CLINICAL EXPERIENCE WITH CHLORPROPAMIDE

Geoffrey Walker, Laurance W Kinsell
PMCID: PMC1574396  PMID: 13782713

Abstract

Seventy-eight patients with mild diabetes were treated with chlorpropamide in doses up to 1 gm. daily. Eight showed primary failure to respond and two showed an initial but not a sustained response. Patients whose diabetes was of recent onset and who had not been treated with insulin or a sulfonylurea, required smaller doses than the remainder except for a group of patients who had been diabetic for more than 15 years.

The average dose for the 64 patients who took chlorpropamide for more than three months was 0.46 gm. per day. Serious side effects were uncommon and disappeared when the drug was stopped. One patient became jaundiced, one had a rash, and one showed granulocytopenia. Changes in liver function tests were seen in 17 out of 56 patients treated for more than three months and were correlated with the dosage of the drug and the duration of treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURRELL Z. L., Jr, MARTINEZ A., BURRELL L. O. One year of clinical experience with chlorpropamide in more than one hundred diabetic patients. Ann N Y Acad Sci. 1959 Mar 30;74(3):696–700. doi: 10.1111/j.1749-6632.1959.tb39598.x. [DOI] [PubMed] [Google Scholar]
  2. CARLOZZI M., IEZZONI D. G., SILVER L. Blood levels of chlorpropamide in normal men following chronic administration. Ann N Y Acad Sci. 1959 Mar 30;74(3):788–793. doi: 10.1111/j.1749-6632.1959.tb39607.x. [DOI] [PubMed] [Google Scholar]
  3. CRAIG J. W., MILLER M., MILLS F. D., NICKERSON N. A comparison of the acute hypoglycemic potencies of tolbutamide and chlorpropamide. Ann N Y Acad Sci. 1959 Mar 30;74(3):618–620. doi: 10.1111/j.1749-6632.1959.tb39586.x. [DOI] [PubMed] [Google Scholar]
  4. FORSHAM P. H., MAGID G. J., DOROSIN D. E. A clinical comparison of chlorpropamide and tolbutamide. Ann N Y Acad Sci. 1959 Mar 30;74(3):672–682. doi: 10.1111/j.1749-6632.1959.tb39594.x. [DOI] [PubMed] [Google Scholar]
  5. GARCIA REYES J. A., PENA J. C., BARROSO E., ANTON F. B., GONZALEZ C. Clinical experience in the use of chlorpropamide in the treatment of diabetes mellitus. Ann N Y Acad Sci. 1959 Mar 30;74(3):1012–1020. doi: 10.1111/j.1749-6632.1959.tb39637.x. [DOI] [PubMed] [Google Scholar]
  6. HAMFF L. H., FERRIS H. A., EVANS E. C., WHITEMAN H. W. The effects of tolbutamide and chlorpropamide on patients exhibiting jaundice as a result of previous chlorpropamide therapy. Ann N Y Acad Sci. 1959 Mar 30;74(3):820–829. doi: 10.1111/j.1749-6632.1959.tb39611.x. [DOI] [PubMed] [Google Scholar]
  7. KNAUFF R. E., FAJANS S. S., RAMIREZ E., CONN J. W. Metabolic studies of chlorpropamide in normal men and in diabetic subjects. Ann N Y Acad Sci. 1959 Mar 30;74(3):603–617. doi: 10.1111/j.1749-6632.1959.tb39585.x. [DOI] [PubMed] [Google Scholar]
  8. LEE C. T., Jr, SCHLESS G. L., DUNCAN G. G. Clinical experiences with chlorpropamide: a double-blind study. Ann N Y Acad Sci. 1959 Mar 30;74(3):738–745. doi: 10.1111/j.1749-6632.1959.tb39603.x. [DOI] [PubMed] [Google Scholar]
  9. LINDEMAN R. D. Severe hypoglycemia caused by chlorpropamide. Diabetes. 1960 Mar-Apr;9:110–113. doi: 10.2337/diab.9.2.110. [DOI] [PubMed] [Google Scholar]
  10. McLAMORE W. M., FANELLI G. M., LAUBACH G. D., P'AN S. Y. Hypoglycemic sulfonylureas: effect of structure on activity. Ann N Y Acad Sci. 1959 Mar 30;74(3):443–448. doi: 10.1111/j.1749-6632.1959.tb39567.x. [DOI] [PubMed] [Google Scholar]
  11. PINES K. L., LEIFER E., GOODMAN D. Influence of chlorpropamide upon post-pancreatectomy and spontaneous diabetes. Ann N Y Acad Sci. 1959 Mar 30;74(3):997–1002. doi: 10.1111/j.1749-6632.1959.tb39633.x. [DOI] [PubMed] [Google Scholar]
  12. REICHEL J., GOLDBERG S. B., ELLENBERG M., SCHAFFNER F. Intrahepatic cholestasis following administration of chlorpropamide. Report of a case with electron microscopic observations. Am J Med. 1960 Apr;28:654–660. doi: 10.1016/0002-9343(60)90161-3. [DOI] [PubMed] [Google Scholar]
  13. SIGNORELLI S. Tolerance for alcohol in patients on chlorpropamide. Ann N Y Acad Sci. 1959 Mar 30;74(3):900–903. doi: 10.1111/j.1749-6632.1959.tb39621.x. [DOI] [PubMed] [Google Scholar]
  14. WALKER G., SLATER J. D., WESTLAKE E. K., NABARRO J. D. Clinical experience with tolbutamide. Br Med J. 1957 Aug 10;2(5040):323–325. doi: 10.1136/bmj.2.5040.323. [DOI] [PMC free article] [PubMed] [Google Scholar]

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