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. 1961 Jun;94(6):369–377.

THE ETIOLOGY OF SCHIZOPHRENIA—A Review

Antonio J Ferreira
PMCID: PMC1574422  PMID: 13699087

Abstract

The causes and the nature of the psychiatric disorder labeled schizophrenia remain vexingly obscure. Perhaps as an expression of a still extant body-mind controversy, most of the experiments and statements made toward an elucidation of the problem follow one or the other of two opposing postulations: (a) That its origin is genetico-organic; (b) that it is environmental. In a review of the outstanding “facts” for either argument, it is notable that they presuppose not only a difference in theoretical frameworks, but two radically distinct outlooks. This is reflected in therapy, a field in which organicists and environmentalists stand even further apart; the organicist, relying heavily on electroshock and drugs, hopes to counteract a hypothetical body malfunction, and the environmentalist, through psychotherapy, attempts to make it possible for the patient to disentangle his own conflicting feelings and reaction patterns.

Between the two an eclectic position seems hardly tenable. For, in spite of voluminous research and speculation, it has not been possible to build a bridge between the two camps and integrate different outlooks which, at times, have brought psychiatry almost to the point of schism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABOOD L. G., GIBBS F. A., GIBBS E. Comparative study of blood ceruloplasmin in schizophrenia and other disorders. AMA Arch Neurol Psychiatry. 1957 Jun;77(6):643–645. doi: 10.1001/archneurpsyc.1957.02330360101011. [DOI] [PubMed] [Google Scholar]
  2. AKERFELDT S. Oxidation of N, N-dimethyl-p-phenylenediamine by serum from patients with mental disease. Science. 1957 Jan 18;125(3238):117–119. doi: 10.1126/science.125.3238.117. [DOI] [PubMed] [Google Scholar]
  3. ANGEL C., LEACH B. E., MARTENS S., COHEN M., HEATH R. G. Serum oxidation tests in schizophrenic and normal subjects; copper levels, adrenaline and N, N-dimethyl-p-phenylenediamine oxidation rates, and glutathione concentration. AMA Arch Neurol Psychiatry. 1957 Nov;78(5):500–504. doi: 10.1001/archneurpsyc.1957.02330410064010. [DOI] [PubMed] [Google Scholar]
  4. BANERJEE S., AGARWAL P. S. Tryptophan-nicotinic acid metabolism in schizophrenia. Proc Soc Exp Biol Med. 1958 Mar;97(3):657–659. doi: 10.3181/00379727-97-23837. [DOI] [PubMed] [Google Scholar]
  5. BENDER L. Childhood schizophrenia. Psychiatr Q. 1953 Oct;27(4):663–681. doi: 10.1007/BF01562517. [DOI] [PubMed] [Google Scholar]
  6. BERCEL N. A. A study of the influence of schizophrenic serum on the behavior of the spider Zilla-x-notata. AMA Arch Gen Psychiatry. 1960 Feb;2:189–209. doi: 10.1001/archpsyc.1960.03590080065011. [DOI] [PubMed] [Google Scholar]
  7. BLOCK J., PATTERSON V., BLOCK J., JACKSON D. D. A study of the parents of schizophrenic and neurotic children. Psychiatry. 1958 Nov;21(4):387–397. doi: 10.1080/00332747.1958.11023147. [DOI] [PubMed] [Google Scholar]
  8. BOGOCH S., DUSSIK K. T., LEVER P. G. Clinical status and cerebrospinal fluid "total neuraminic acid". AMA Arch Gen Psychiatry. 1959 Oct;1:441–449. doi: 10.1001/archpsyc.1959.03590040111012. [DOI] [PubMed] [Google Scholar]
  9. BOWEN M., DYSINGER R. H., BASAMANIA B. The role of the father in families with a schizophrenic patient. Am J Psychiatry. 1959 May;115(11):1017–1020. doi: 10.1176/ajp.115.11.1017. [DOI] [PubMed] [Google Scholar]
  10. COHEN G., HOLLAND B., GOLDENBERG M. Disappearance rates of infused epinephrine and norepinephrine from plasma: a comparison of normal and schizophrenic subjects. AMA Arch Gen Psychiatry. 1959 Aug;1:228–231. doi: 10.1001/archpsyc.1959.03590020124012. [DOI] [PubMed] [Google Scholar]
  11. COHEN G., HOLLAND B., GOLDENBERG M. The stability of epinephrine and arterenol (norepinephrine) in plasma and serum; a comparison of normal and schizophrenic subjects. AMA Arch Neurol Psychiatry. 1958 Oct;80(4):484–487. doi: 10.1001/archneurpsyc.1958.02340100084020. [DOI] [PubMed] [Google Scholar]
  12. COLBERT E. G., KOELGLER R. R., MARKHAM C. H. Vestibular dysfunction in childhood schizophrenia. AMA Arch Gen Psychiatry. 1959 Dec;1:600–617. doi: 10.1001/archpsyc.1959.03590060062006. [DOI] [PubMed] [Google Scholar]
  13. FEDOROFF S. Toxicity of schizophrenics' blood serum in tissue culture. J Lab Clin Med. 1956 Jul;48(1):55–62. [PubMed] [Google Scholar]
  14. FERREIRA A. J. The "double-bind" and delinquent behavior. Arch Gen Psychiatry. 1960 Oct;3:359–367. doi: 10.1001/archpsyc.1960.01710040029005. [DOI] [PubMed] [Google Scholar]
  15. FERREIRA A. J. The pregnant woman's emotional attitude and its reflection of the newborn. Am J Orthopsychiatry. 1960 Jul;30:553–561. doi: 10.1111/j.1939-0025.1960.tb02070.x. [DOI] [PubMed] [Google Scholar]
  16. FISHER S., BOYD I., WALKER D., SHEER D. Parents of schizophrenics, neurotics, and normals. AMA Arch Gen Psychiatry. 1959 Aug;1:149–166. doi: 10.1001/archpsyc.1959.03590020045003. [DOI] [PubMed] [Google Scholar]
  17. FLACH F. F., CELIAN C. I., RAWSON R. W. Treatment of psychiatric disorders with triiodothyronine. Am J Psychiatry. 1958 Mar;114(9):841–842. doi: 10.1176/ajp.114.9.841. [DOI] [PubMed] [Google Scholar]
  18. FREEDMAN A. M., GINSBERG V. Exchange transfusions in schizophrenic patients. J Nerv Ment Dis. 1958 Mar;126(3):294–301. doi: 10.1097/00005053-195803000-00009. [DOI] [PubMed] [Google Scholar]
  19. GADDUM J. H. Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine. J Physiol. 1953 Jul;121(1):15P–15P. [PubMed] [Google Scholar]
  20. GEORGI F., RIEDER H. P., WEBER R., FISCHER R. Remarks on Fischer's article, Stress and the toxicity of schizophrenic serum. Science. 1954 Sep 24;120(3117):504–506. doi: 10.1126/science.120.3117.504-a. [DOI] [PubMed] [Google Scholar]
  21. GHENT L., FREEDMAN A. M. Comparison of effects of normal and schizophrenic serum on motor performance in rats. Am J Psychiatry. 1958 Nov;115(5):465–466. doi: 10.1176/ajp.115.5.465. [DOI] [PubMed] [Google Scholar]
  22. GOTTLIEB J. S., FROHMAN C. E., BECKETT P. G., TOURNEY G., SENF R. Production of high-energy phosphate bonds in schizophrenia. AMA Arch Gen Psychiatry. 1959 Sep;1:243–249. doi: 10.1001/archpsyc.1959.03590030027002. [DOI] [PubMed] [Google Scholar]
  23. GOTTLIEB J. S., FROHMAN C. E., TOURNEY G., BECKETT P. G. Energy transfer systems in schizophrenia: adenosinetriphosphate (ATP). AMA Arch Neurol Psychiatry. 1959 Apr;81(4):504–508. doi: 10.1001/archneurpsyc.1959.02340160102014. [DOI] [PubMed] [Google Scholar]
  24. HARLOW H. F., ZIMMERMANN R. R. Affectional responses in the infant monkey; orphaned baby monkeys develop a strong and persistent attachment to inanimate surrogate mothers. Science. 1959 Aug 21;130(3373):421–432. doi: 10.1126/science.130.3373.421. [DOI] [PubMed] [Google Scholar]
  25. HEATH R. G., MARTENS S., LEACH B. E., COHEN M., ANGEL C. Effect on behavior in humans with the administration of taraxein. Am J Psychiatry. 1957 Jul;114(1):14–24. doi: 10.1176/ajp.114.1.14. [DOI] [PubMed] [Google Scholar]
  26. HEATH R. G., MARTENS S., LEACH B. E., COHEN M., FEIGLEY C. A. Behavioral changes in nonpsychotic volunteers following the administration of taraxein, the substance obtained from serum of schizophrenic patients. Am J Psychiatry. 1958 Apr;114(10):917–920. doi: 10.1176/ajp.114.10.917. [DOI] [PubMed] [Google Scholar]
  27. HESS E. H. Imprinting, an effect of early experience, imprinting determines later social behavior in animals. Science. 1959 Jul 17;130(3368):133–141. doi: 10.1126/science.130.3368.133. [DOI] [PubMed] [Google Scholar]
  28. HOFFER A., KENYON M. Conversion of adrenaline to adrenolutin in human blood serum. AMA Arch Neurol Psychiatry. 1957 Apr;77(4):437–438. doi: 10.1001/archneurpsyc.1957.02330340113017. [DOI] [PubMed] [Google Scholar]
  29. JACKSON D. D. The question of family homeostasis. Psychiatr Q Suppl. 1957;31(Suppl 1):79–90. [PubMed] [Google Scholar]
  30. JACKSON D. D., WEAKLAND J. H. Schizophrenic symptoms and family interaction. AMA Arch Gen Psychiatry. 1959 Dec;1:618–621. doi: 10.1001/archpsyc.1959.03590060080007. [DOI] [PubMed] [Google Scholar]
  31. LAUER J. W., INSKIP W. M., BERNSOHN J., ZELLER E. A. Observations of schizophrenic patients after iproniazid and tryptophan. AMA Arch Neurol Psychiatry. 1958 Jul;80(1):122–130. doi: 10.1001/archneurpsyc.1958.02340070140021. [DOI] [PubMed] [Google Scholar]
  32. LIDZ T., CORNELISON A., TERRY D., FLECK S. Intrafamilial environment of the schizophrenic patient. VI. The transmission of irrationality. AMA Arch Neurol Psychiatry. 1958 Mar;79(3):305–316. doi: 10.1001/archneurpsyc.1958.02340030069012. [DOI] [PubMed] [Google Scholar]
  33. MANN J. D., LABROSSE E. H. Urinary excretion of phenolic acids by normal and schizophrenic male patients. AMA Arch Gen Psychiatry. 1959 Nov;1:547–551. [PubMed] [Google Scholar]
  34. MARK J. C. The attitudes of the mothers of male schizophrenics toward child behavior. J Abnorm Psychol. 1953 Apr;48(2):185–189. doi: 10.1037/h0055090. [DOI] [PubMed] [Google Scholar]
  35. MCGEER P. L., MCGEER E. G., BOULDING J. E. Relation of aromatic amino acids to excretory pattern of schizophrenics. Science. 1956 Jun 15;123(3207):1078–1080. doi: 10.1126/science.123.3207.1078-a. [DOI] [PubMed] [Google Scholar]
  36. MCGEER P. L., MCGEER E. G., GIBSON W. C. Aromatic excretory pattern of schizophrenics. Science. 1956 Jun 8;123(3206):1029–1030. doi: 10.1126/science.123.3206.1029. [DOI] [PubMed] [Google Scholar]
  37. McGEER E. G., BROWN W. T., McGEER P. L. Aromatic metabolism in schizophrenia. II. Bidimensional urinary chromatograms. J Nerv Ment Dis. 1957 Apr-Jun;125(2):176–180. doi: 10.1097/00005053-195704000-00003. [DOI] [PubMed] [Google Scholar]
  38. McGEER P. L., McNAIR F. E., McGEER E. G., GIBSON W. C. Aromatic metabolism in schizophrenia. I. Statistical evidence for aromaturia. J Nerv Ment Dis. 1957 Apr-Jun;125(2):166–175. [PubMed] [Google Scholar]
  39. NICKLIN G., SACKS W., WEHRHEIM H., SIMPSON G., SAUNDERS J., KLINE N. Cross transfusion in schizophrenia. Am J Psychiatry. 1959 Oct;116:334–336. doi: 10.1176/ajp.116.4.334. [DOI] [PubMed] [Google Scholar]
  40. PLETSCHER A., SHORE P. A., BRODIE B. B. Serotonin release as a possible mechanism of reserpine action. Science. 1955 Aug 26;122(3165):374–375. doi: 10.1126/science.122.3165.374. [DOI] [PubMed] [Google Scholar]
  41. RINKEL M., DeSHON H. J., HYDE R. W., SOLOMON H. C. Experimental schizophrenia-like symptoms. Am J Psychiatry. 1952 Feb;108(8):572–578. doi: 10.1176/ajp.108.8.572. [DOI] [PubMed] [Google Scholar]
  42. SHAW C. R., LUCAS J., RABINOVITCH R. D. Metabolic studies in childhood schizophrenia. Effect of tryptophan loading on indole excretion. AMA Arch Gen Psychiatry. 1959 Oct;1:366–371. doi: 10.1001/archpsyc.1959.03590040036003. [DOI] [PubMed] [Google Scholar]
  43. SHAW E., WOOLLEY D. W. Some serotoninlike activities of lysergic acid diethylamide. Science. 1956 Jul 20;124(3212):121–122. doi: 10.1126/science.124.3212.121. [DOI] [PubMed] [Google Scholar]
  44. SIEGEL M., NISWANDER G. D., SACHS E., Jr, STAVROS D. Taraxein, fact or artifact. Am J Psychiatry. 1959 Mar;115(9):819–820. doi: 10.1176/ajp.115.9.819. [DOI] [PubMed] [Google Scholar]
  45. SMITH K., SINES J. O. Demonstration of a peculiar odor in the sweat of schizophrenic patients. AMA Arch Gen Psychiatry. 1960 Feb;2:184–188. doi: 10.1001/archpsyc.1960.03590080060010. [DOI] [PubMed] [Google Scholar]
  46. SOLOMON P., LEIDERMAN P. H., MENDELSON J., WEXLER D. Sensory deprivation; a review. Am J Psychiatry. 1957 Oct;114(4):357–363. doi: 10.1176/ajp.114.4.357. [DOI] [PubMed] [Google Scholar]
  47. SONTAG L. W. The genetics of differences in psychosomatic patterns in childhood. Am J Orthopsychiatry. 1950 Jul;20(3):479–489. doi: 10.1111/j.1939-0025.1950.tb06062.x. [DOI] [PubMed] [Google Scholar]
  48. SZALITA-PEMOW A. Remark on pathogenesis and treatment of schizophrenia. Psychiatry. 1951 Aug;14(3):295–300. doi: 10.1080/00332747.1951.11022830. [DOI] [PubMed] [Google Scholar]
  49. TURNER E. K. The syndrome in the infant resulting from maternal emotional tension during pregnancy. Med J Aust. 1956 Feb 11;43(6):221–222. [PubMed] [Google Scholar]
  50. TURNER W. J., MAUSS E. A. Serotonin (5-hydroxytryptamine) and acetylcholine in human ventricular and spinal fluids. AMA Arch Gen Psychiatry. 1959 Dec;1:646–650. doi: 10.1001/archpsyc.1959.03590060108012. [DOI] [PubMed] [Google Scholar]
  51. WOOLLEY D. W., SHAW E. Some neurophysiological aspects of serotonin. Br Med J. 1954 Jul 17;2(4880):122–126. doi: 10.1136/bmj.2.4880.122. [DOI] [PMC free article] [PubMed] [Google Scholar]

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