Abstract
Latent psoriasis is a state which exists before the development of clinical psoriasis and wherein probably some as yet undiscovered defect exists. Investigation concerning a group of persons with latent psoriasis might disclose basic aberrations.
The natural course of psoriasis may be altered by therapy. Folic acid antagonists and intradermal corticosteroids may at times eclipse psoriatic lesions. Oral adrenal corticosteroids may prove morbidistatic but on discontinuance a rebound flare may occur which is both protracted and recalcitrant. Antimalarial agents when employed as therapy for coexistent arthridites may cause psoriasis to become more severe.
The Goeckerman regimen which employs topical tar and ultraviolet light therapy produces in some 75 per cent of patients a prolonged remission. As it is safe and repeatable it is favored for the usual severe case of psoriasis.
Psoriasis therapy is better assessed by considering its effect on the natural evolution of the disease.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHURCH R. The prospect of psoriasis. Br J Dermatol. 1958 Apr;70(4):139–145. doi: 10.1111/j.1365-2133.1958.tb13306.x. [DOI] [PubMed] [Google Scholar]
- EDMUNDSON W. F., GUY W. B. Treatment of psoriasis with folic acid antagonists. AMA Arch Derm. 1958 Aug;78(2):200–203. doi: 10.1001/archderm.1958.01560080060010. [DOI] [PubMed] [Google Scholar]
- GERARD A. G. Treatment of psoriasis with subdermal infiltration of triamcinolone diacetate suspension. Arch Dermatol. 1960 Apr;81:535–538. doi: 10.1001/archderm.1960.03730040039008. [DOI] [PubMed] [Google Scholar]
- JACOBSON W. The mode of action of folic acid antagonists on cells. J Physiol. 1954 Mar 29;123(3):603–617. doi: 10.1113/jphysiol.1954.sp005073. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NORRLIND R. Psoriasis following infections with hemolytic streptococci. Acta Derm Venereol. 1950;30(1):64–72. [PubMed] [Google Scholar]
- REES R. B., BENNETT J. H., BOSTICK W. L. Aminopterin for psoriasis. AMA Arch Derm. 1955 Aug;72(2):133–143. doi: 10.1001/archderm.1955.03730320035005. [DOI] [PubMed] [Google Scholar]
- REES R. B., BENNETT J. H. Further observations on aminopterin for psoriasis. J Invest Dermatol. 1959 Jan;32(1):61–66. [PubMed] [Google Scholar]
- REINERTSON R. P., WHEATLEY V. R. Studies on the chemical composition of human epidermal lipids. J Invest Dermatol. 1959 Jan;32(1):49–59. [PubMed] [Google Scholar]
- WHEATLEY V. R., FARBER E. M. Studies on the chemical composition of psoriatic scales. J Invest Dermatol. 1961 Mar;36:199–211. doi: 10.1038/jid.1961.34. [DOI] [PubMed] [Google Scholar]
- ZIPRKOWSKI L., HAIM S., BANK H. Atabrine in psoriasis. Acta Med Orient. 1954 Mar-Apr;13(3-4):45–52. [PubMed] [Google Scholar]