Abstract
A 50 per cent dextrose in water solution, containing 1 mg. of hydrocortisone per 100 ml., was used successfully in 70 patients for intravenous nutritional maintenance and repletion. There were no adverse systemic effects during or following 216 infusions. The only undesirable local reaction was the rare occurrence of pain in the arm when the concentrated solutions were given too rapidly. Glycosuria was minimal if the infusion rate did not exceed 0.85 gm. of glucose per kilogram of body weight per hour, particularly if 50 units of insulin were added to each 550 ml. bottle of 50 per cent dextrose. In patients without significantly elevated serum potassium content, 30 mEq. of potassium chloride, acetate or phosphate was added to each bottle to prevent hypokalemia.
Preliminary observations suggest that this new solution may be given safely intravenously, without need for cutdowns or plastic catheters, if the needle is carefully inserted and well immobilized in the arm vein and the duration of the infusion is not too prolonged. Further studies on the effect of such high caloric supplementation plus protein hydrolysates in parenteral nutritional repletion and maintenance are indicated.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CLARK P. B., POLAK A., HAJNAL J. A clinical trial of hydrocortisone in the prevention of transfusion thrombophlebititis. Postgrad Med J. 1960 Jan;36:55–56. doi: 10.1136/pgmj.36.411.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HASSALL J. E., ROUNTREE P. M. Staphylococcal septicaemia. Lancet. 1959 Jan 31;1(7066):213–217. doi: 10.1016/s0140-6736(59)90047-9. [DOI] [PubMed] [Google Scholar]
- KRIEGER H., ABBOTT W. E., LEVEY S., HOLDEN W. D. The use of a fat emulsion as a source of calories in patients requiring intravenous alimentation. Gastroenterology. 1957 Nov;33(5):807–816. [PubMed] [Google Scholar]
- MONCRIEF J. A. Femoral catheters. Ann Surg. 1958 Feb;147(2):166–172. doi: 10.1097/00000658-195802000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOORE F. D. Common patterns of water and electrolyte change in injury, surgery and disease. N Engl J Med. 1958 Feb 6;258(6):277–contd. doi: 10.1056/NEJM195802062580606. [DOI] [PubMed] [Google Scholar]
- MUELLER J. F. Experiences in human beings with an improved fat emulsion for intravenous administration. J Lab Clin Med. 1957 Aug;50(2):257–266. [PubMed] [Google Scholar]
- Pareira M. D., Somogyi M. Rationale of Parenteral Glucose Feeding in the Postoperative State. Ann Surg. 1948 Mar;127(3):417–425. [PMC free article] [PubMed] [Google Scholar]
- RICE C. O., STRICKLER J. H., ERWIN P. D. Parenteral nutrition with a solution containing one thousand calories per liter. AMA Arch Surg. 1952 Jan;64(1):20–27. doi: 10.1001/archsurg.1952.01260010031004. [DOI] [PubMed] [Google Scholar]
- SPENCER F. C., BEAL J. M. The use of a solution of twenty-five per cent glucose and five per cent alcohol in parenteral nutrition; a preliminary report. Ann Surg. 1952 Feb;135(2):234–238. doi: 10.1097/00000658-195202000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]