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. 1996 Oct;37(10):601–609.

A comparison of romifidine and xylazine when used with diazepam/ketamine for short duration anesthesia in the horse.

C L Kerr 1, W N McDonell 1, S S Young 1
PMCID: PMC1576482  PMID: 8896874

Abstract

The purpose of this study was to compare and evaluate sedation with intravenous xylazine (1.1 mg/kg bodyweight [BW]) versus intravenous romifidine (100 micrograms/kg BW) followed by induction of anesthesia with intravenous diazepam (0.04 mg/kg BW) and ketamine (2.2 mg/kg BW). Twelve healthy horses were used in a blinded, randomized, cross-over design. Heart rate, presence of 2nd degree atrioventricular heart blocks (2 degrees AVB), respiratory rate, arterial blood pressures, blood gases, packed cell volume, total serum proteins, and duration of anesthesia and recumbency were recorded. Induction and recovery quality was evaluated using a 0 to 4 score. Response to stimulation with noise, pressure, and cutaneous electrical stimulation was assessed at 5 minute intervals during recumbency to evaluate the depth of anesthesia. Heart rate was lower and 2 degrees AVB more frequent in the romifidine group, while blood pressure was lower in the xylazine group. Duration of anesthesia was longer in the romifidine group (mean 20.8, s mean 2.3 min) versus the xylazine group (mean 15.8, s mean 1.6 min), while induction and recovery were excellent in both groups. Respiratory rates, blood gas values, packed cell volumes, and total protein levels did not differ between groups. The results indicate that romifidine premedication followed by diazepam and ketamine is a very satisfactory regime for short duration intravenous anesthesia in horses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brock N., Hildebrand S. V. A comparison of xylazine-diazepam-ketamine and xylazine-guaifenesin-ketamine in equine anesthesia. Vet Surg. 1990 Nov-Dec;19(6):468–474. doi: 10.1111/j.1532-950x.1990.tb01237.x. [DOI] [PubMed] [Google Scholar]
  2. Brouwer G. J., Hall L. W., Kuchel T. R. Intravenous anaesthesia in horses after xylazine premedication. Vet Rec. 1980 Sep 13;107(11):241–245. doi: 10.1136/vr.107.11.241. [DOI] [PubMed] [Google Scholar]
  3. Butera T. S., Moore J. N., Garner H. E., Amend J. F., Clarke L. L., Hatfield D. G. Diazepam/xylazine/ketamine combination for short-term anesthesia in the horse. Vet Med Small Anim Clin. 1978 Apr;73(4):490,495-6,499. [PubMed] [Google Scholar]
  4. Clarke K. W., Hall L. W. "Xylazine"--a new sedative for horses and cattle. Vet Rec. 1969 Nov 8;85(19):512–517. doi: 10.1136/vr.85.19.512. [DOI] [PubMed] [Google Scholar]
  5. Clarke K. W., Taylor P. M., Watkins S. B. Detomidine/ketamine anaesthesia in the horse. Acta Vet Scand Suppl. 1986;82:167–179. [PubMed] [Google Scholar]
  6. Diamond M. J., Young L. E., Bartram D. H., Gregg A. S., Clutton R. E., Long K. J., Jones R. S. Clinical evaluation of romifidine/ketamine/halothane anaesthesia in horses. Vet Rec. 1993 Jun 5;132(23):572–575. doi: 10.1136/vr.132.23.572. [DOI] [PubMed] [Google Scholar]
  7. England G. C., Clarke K. W., Goossens L. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther. 1992 Jun;15(2):194–201. doi: 10.1111/j.1365-2885.1992.tb01007.x. [DOI] [PubMed] [Google Scholar]
  8. Fisher R. J. A field trial of ketamine anaesthesia in the horse. Equine Vet J. 1984 May;16(3):176–179. doi: 10.1111/j.2042-3306.1984.tb01895.x. [DOI] [PubMed] [Google Scholar]
  9. Garner H. E., Amend J. F., Rosborough J. P. Effects on Bay Va 1470 on cardiovascular parameters in ponies. Vet Med Small Anim Clin. 1971 Oct;66(10):1016–passim. [PubMed] [Google Scholar]
  10. Gasthuys F., De Moor A., Parmentier D. Haemodynamic changes during sedation in ponies. Vet Res Commun. 1990;14(4):309–327. doi: 10.1007/BF00350713. [DOI] [PubMed] [Google Scholar]
  11. Hall L. W., Gillespie J. R., Tyler W. S. Alveolar-arterial oxygen tension differences in anaesthetized horses. Br J Anaesth. 1968 Aug;40(8):560–568. doi: 10.1093/bja/40.8.560. [DOI] [PubMed] [Google Scholar]
  12. Hall L. W., Taylor P. M. Clinical trial of xylazine with ketamine in equine anaesthesia. Vet Rec. 1981 Jun 6;108(23):489–493. doi: 10.1136/vr.108.23.489. [DOI] [PubMed] [Google Scholar]
  13. Hubbell J. A., Bednarski R. M., Muir W. W. Xylazine and tiletamine-zolazepam anesthesia in horses. Am J Vet Res. 1989 May;50(5):737–742. [PubMed] [Google Scholar]
  14. Kerr D. D., Jones E. W., Huggins K., Edwards W. C. Sedative and other effects of xylazine given intravenously to horses. Am J Vet Res. 1972 Mar;33(3):525–532. [PubMed] [Google Scholar]
  15. Lin H. C., Branson K. R., Thurmon J. C., Benson G. J., Tranquilli W. J., Olson W. A., Vähä-Vahe A. T. Ketamine, Telazol, xylazine and detomidine. A comparative anesthetic drug combinations study in ponies. Acta Vet Scand. 1992;33(2):109–115. doi: 10.1186/BF03547317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Matthews N. S., Dollars N. S., Young D. B., Shawley R. V. Prolongation of xylazine/ketamine induced recumbency time with temazepam in horses. Equine Vet J. 1991 Jan;23(1):8–10. doi: 10.1111/j.2042-3306.1991.tb02704.x. [DOI] [PubMed] [Google Scholar]
  17. Matthews N. S., Hartsfield S. M., Cornick J. L., Williams J. D., Beasley A. A comparison of injectable anesthetic combinations in horses. Vet Surg. 1991 Jul-Aug;20(4):268–273. doi: 10.1111/j.1532-950x.1991.tb01262.x. [DOI] [PubMed] [Google Scholar]
  18. McCashin F. B., Gabel A. A. Evaluation of xylazine as a sedative and preanesthetic agent in horses. Am J Vet Res. 1975 Oct;36(10):1421–1429. [PubMed] [Google Scholar]
  19. Muir W. W., Sams R. A., Huffman R. H., Noonan J. S. Pharmacodynamic and pharmacokinetic properties of diazepam in horses. Am J Vet Res. 1982 Oct;43(10):1756–1762. [PubMed] [Google Scholar]
  20. Muir W. W., Skarda R. T., Milne D. W. Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses. Am J Vet Res. 1977 Feb;38(2):195–201. [PubMed] [Google Scholar]
  21. Muir W. W., Skarda R. T., Sheehan W. Evaluation of xylazine, guaifenesin, and ketamine hydrochloride for restraint in horses. Am J Vet Res. 1978 Aug;39(8):1274–1278. [PubMed] [Google Scholar]
  22. Sarazan R. D., Starke W. A., Krause G. F., Garner H. E. Cardiovascular effects of detomidine, a new alpha 2-adrenoceptor agonist, in the conscious pony. J Vet Pharmacol Ther. 1989 Dec;12(4):378–388. doi: 10.1111/j.1365-2885.1989.tb00688.x. [DOI] [PubMed] [Google Scholar]
  23. Schatzmann U., Koehli M., Dudan F., Rohr W., Jones R. S. Effect of postural changes on certain circulatory and respiratory values in the horse. Am J Vet Res. 1982 Jun;43(6):1003–1005. [PubMed] [Google Scholar]
  24. Short C. E., Matthews N., Harvey R., Tyner C. L. Cardiovascular and pulmonary function studies of a new sedative/analgetic (detomidine/Domosedan) for use alone in horses or as a preanesthetic. Acta Vet Scand Suppl. 1986;82:139–155. [PubMed] [Google Scholar]
  25. Szeligowski E., Janicki A. M., Krzeski M. Detomidine (Domosedan) in sedation, premedication and general anaesthesia of horses. Acta Vet Scand Suppl. 1986;82:181–185. [PubMed] [Google Scholar]
  26. Thurmon J. C., Benson G. J. Injectable anesthetics and anesthetic adjuncts. Vet Clin North Am Equine Pract. 1987 Apr;3(1):15–36. doi: 10.1016/s0749-0739(17)30689-2. [DOI] [PubMed] [Google Scholar]
  27. Wagner A. E., Muir W. W., 3rd, Hinchcliff K. W. Cardiovascular effects of xylazine and detomidine in horses. Am J Vet Res. 1991 May;52(5):651–657. [PubMed] [Google Scholar]
  28. Wan P. Y., Trim C. M., Mueller P. O. Xylazine-ketamine and detomidine-tiletamine-zolazepam anesthesia in horses. Vet Surg. 1992 Jul-Aug;21(4):312–318. doi: 10.1111/j.1532-950x.1992.tb00072.x. [DOI] [PubMed] [Google Scholar]
  29. Waterman A. E., Robertson S. A., Lane J. G. Pharmacokinetics of intravenously administered ketamine in the horse. Res Vet Sci. 1987 Mar;42(2):162–166. [PubMed] [Google Scholar]
  30. Watkins S. B., Watney G. C., Hall L. W., Houlton J. E. A clinical trial of three anaesthetic regimens for the castration of ponies. Vet Rec. 1987 Mar 21;120(12):274–276. doi: 10.1136/vr.120.12.274. [DOI] [PubMed] [Google Scholar]
  31. Young S. S. Cardiorespiratory responses to electrical stimulation of the buccal mucosa in ponies. Res Vet Sci. 1990 Nov;49(3):268–274. [PubMed] [Google Scholar]

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