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. 1997 Jan;38(1):45–47.

Systemic adverse reactions in young Simmental calves following administration of a combination vaccine.

J A Ellis 1, C Yong 1
PMCID: PMC1576671  PMID: 8993786

Abstract

Combination vaccines containing viral and bacterial antigens are commonly used in veterinary practice and have been associated with adverse reactions. A group of young Simmental calves developed fever and depression following administration of a mixed vaccine, and 1 died with pulmonary edema, suggesting that endotoxins or other bacterial components may interact synergistically with some adjuvants to cause an enhanced pathologic inflammatory response in some individuals.

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Selected References

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