Abstract
Immune complex levels were measured in serum and synovial fluid obtained from 10 patients who developed arthritis 3-8 days after the onset of meningococcal meningitis. Mean serum immune complex levels were lower in these patients than in eight age matched control patients with meningococcal disease who did not develop late complications. This observation suggests that meningococcal arthritis follows local formation of immune complexes in the synovium rather than deposition of circulating immune complexes. Purified meningococcal polysaccharide antigen-induced synovitis when injected into the knee of rabbits previously sensitized by i.v. injection with heat killed meningococci.
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- Blakebrough I. S., Greenwood B. M., Whittle H. C., Bradley A. K., Gilles H. M. The epidemiology of infections due to Neisseria meningitidis and Neisseria lactamica in a northern Nigerian community. J Infect Dis. 1982 Nov;146(5):626–637. doi: 10.1093/infdis/146.5.626. [DOI] [PubMed] [Google Scholar]
- Davis J. A., Peters N., Mohammed I., Major G. A., Holborow E. J. Circulating immune complexes in a patient with meningococcal disease. Br Med J. 1976 Jun 12;1(6023):1445–1446. doi: 10.1136/bmj.1.6023.1445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenwood B. M., Onyewotu I. I., Whittle H. C. Complement and meningococcal infection. Br Med J. 1976 Apr 3;1(6013):797–799. doi: 10.1136/bmj.1.6013.797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenwood B. M., Whittle H. C., Bryceson A. D. Allergic complications of meningococcal disease. II. Immunological investigations. Br Med J. 1973 Jun 30;2(5869):737–740. doi: 10.1136/bmj.2.5869.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenwood B. M., Whittle H. C., Dominic-Rajkovic O. Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections. Lancet. 1971 Sep 4;2(7723):519–521. doi: 10.1016/s0140-6736(71)90439-9. [DOI] [PubMed] [Google Scholar]
- Jarrett M. P., Moses S., Barland P., Miller M. H. Articular complications of meningococcal meningitis. An immune complex disorder. Arch Intern Med. 1980 Dec;140(12):1665–1666. [PubMed] [Google Scholar]
- Larson H. E., Nicholson K. G., Loewi G., Tyrrell D. A., Posner J. Arthritis after meningococcal meningitis. Br Med J. 1977 Mar 5;1(6061):618–618. doi: 10.1136/bmj.1.6061.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rainford D. J., Woodrow D. F., Sloper J. C., de Wardener H. E., Griffiths I. Post meningococcal acute glomerular nephritis. Clin Nephrol. 1978 Jun;9(6):249–253. [PubMed] [Google Scholar]
- Schaad U. B. Arthritis in disease due to Neisseria meningitidis. Rev Infect Dis. 1980 Nov-Dec;2(6):880–888. doi: 10.1093/clinids/2.6.880. [DOI] [PubMed] [Google Scholar]
- Whittle H. C., Abdullahi M. T., Fakunle F. A., Greenwood B. M., Bryceson A. D., Parry E. H., Turk J. L. Allertic complications of meningococcal disease. I. Clinical aspects. Br Med J. 1973 Jun 30;2(5869):733–737. doi: 10.1136/bmj.2.5869.733. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whittle H. C., Greenwood B. M., Davidson N., Tomkins A., Tugwell P., Warrell D. A., Zalin A., BRYCESON A. D., Parry E. H., Brueton M. Meningococcal antigen in diagnosis and treatment of group A meningococcal infections. Am J Med. 1975 Jun;58(6):823–828. doi: 10.1016/0002-9343(75)90638-5. [DOI] [PubMed] [Google Scholar]
- Zubler R. H., Lange G., Lambert P. H., Miescher P. A. Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol. 1976 Jan;116(1):232–235. [PubMed] [Google Scholar]
- Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]