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. 1985 Apr;60(1):207–216.

The amyloid in familial amyloid cardiomyopathy of Danish origin is related to pre-albumin.

G Husby, P J Ranløv, K Sletten, G Marhaug
PMCID: PMC1576986  PMID: 3924450

Abstract

Amyloid obtained from the myocardium of a patient (Han) with familial amyloid cardiomyopathy of Danish origin was studied. Gel filtration and electrophoresis of purified and denatured amyloid fibrils Han revealed various fractions ranging in mol. wt from 40,000 to 8,000 daltons. Amyloid Han and fractions reacted with an antiserum against amyloid Han showing a reaction of identity with each other; partial identity between Han and human pre-albumin was observed, while no reaction was seen with AA or AL proteins. Cardiac tissue sections from Han showed reactivity with antisera to amyloid Han, pre-albumin and protein AP, but not with anti-AA or anti-AL in indirect immunofluorescence. Amino acid composition and sequence studies of a protein fraction of amyloid Han with mol. wt 15,000 daltons confirmed the structural relationship with pre-albumin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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