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. 1985 May;60(2):303–310.

A non-specific inhibitor produced by Candida albicans activated T cells impairs cell proliferation by inhibiting interleukin-1 production.

G Lombardi, D Vismara, E Piccolella, V Colizzi, G L Asherson
PMCID: PMC1577044  PMID: 3891166

Abstract

Human T lymphocytes cultured in vitro for 5 days with Candida albicans purified polysaccharide (MPPS) produce and antigen non-specific inhibitor (nsINH) which blocks cell proliferation when added at the beginning of the culture. The antigen presenting function of antigen pulsed adherent cells (macrophages) is significantly impaired by incubation in nsINH. Further analysis shows that nsINH blocks the production of interleukin-1 both from human mononuclear cells stimulated with lipopolysaccharide. Furthermore, the production of interleukin-2 (IL-2) is also suppressed when MPPS stimulated cells are cultured in presence of nsINH. However nsINH does not affect the appearance of IL-2 responsive cells as the addition of gibbon IL-2 to the culture fully reverses the suppressive effect of nsINH on blast transformation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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