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. 1985 Jun;60(3):637–644.

Anti-acetylcholine receptor idiotypes in myasthenia gravis analysed by rabbit anti-sera.

B Lang, A J Roberts, A Vincent, J Newsom-Davis
PMCID: PMC1577199  PMID: 4017289

Abstract

Anti-idiotype sera, raised in rabbits against anti-acetylcholine receptor (AChR) (idiotype) purified from the serum of three myasthenia gravis patients, inhibited binding of homologous idiotype to the AChR by up to 80%. The expression of idiotype in the three individuals changed very little over a period of several years, during which they showed a declining trend in overall anti-AChR antibody. Only one of the four anti-idiotype sera inhibited the binding of anti-AChR from a number of other patients. Our results indicate a consistency of idiotype expression within an individual, and fail to show substantial idiotype sharing between individuals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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