Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1985 Aug;61(2):283–289.

T suppressor cell function and number in children with liver disease.

K T Nouri-Aria, A Lobo-Yeo, D Vergani, G Mieli-Vergani, A L Eddleston, A P Mowat
PMCID: PMC1577306  PMID: 2931221

Abstract

Con A stimulated suppressor cell function and the proportion of suppressor T cells were reduced in children with untreated chronic active hepatitis (CAH) but were normal in corticosteroid treated CAH patients, patients with severe acute hepatitis and inactive chronic liver disease. Adults with CAH also have defective suppressor function but a normal proportion of T suppressor cells. This difference may account for the observation that relapse after treatment withdrawal is less frequent in children than in adults.

Full text

PDF
283

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander G. J., Nouri-Aria K. T., Eddleston A. L., Williams R. Contrasting relations between suppressor-cell function and suppressor-cell number in chronic liver disease. Lancet. 1983 Jun 11;1(8337):1291–1293. doi: 10.1016/s0140-6736(83)92410-8. [DOI] [PubMed] [Google Scholar]
  2. Arasu T. S., Wyllie R., Hatch T. F., Fitzgerald J. F. Management of chronic aggressive hepatitis in children and adolescents. J Pediatr. 1979 Oct;95(4):514–522. doi: 10.1016/s0022-3476(79)80754-4. [DOI] [PubMed] [Google Scholar]
  3. Frazer I. H., Mackay I. R. T lymphocyte subpopulations defined by two sets of monoclonal antibodies in chronic active hepatitis and systemic lupus erythematosus. Clin Exp Immunol. 1982 Oct;50(1):107–114. [PMC free article] [PubMed] [Google Scholar]
  4. Gold E. R., Fudenberg H. H. Chromic chloride: a coupling reagent for passive hemagglutination reactions. J Immunol. 1967 Nov;99(5):859–866. [PubMed] [Google Scholar]
  5. Hammarström L., Bird A. G., Britton S., Smith C. I. Pokeweed mitogen induced differentiation of human B cells: evaluation by a protein A haemolytic plaque assay. Immunology. 1979 Sep;38(1):181–189. [PMC free article] [PubMed] [Google Scholar]
  6. Hegarty J. E., Nouri Aria K. T., Portmann B., Eddleston A. L., Williams R. Relapse following treatment withdrawal in patients with autoimmune chronic active hepatitis. Hepatology. 1983 Sep-Oct;3(5):685–689. doi: 10.1002/hep.1840030510. [DOI] [PubMed] [Google Scholar]
  7. Hodgson H. J., Wands J. R., Isselbacher K. J. Alteration in suppressor cell activity in chronic active hepatitis. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1549–1553. doi: 10.1073/pnas.75.3.1549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jensen D. M., McFarlane I. G., Portmann B. S., Eddleston A. L., Williams R. Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med. 1978 Jul 6;299(1):1–7. doi: 10.1056/NEJM197807062990101. [DOI] [PubMed] [Google Scholar]
  9. Kakumu S., Yata K., Kashio T. Immunoregulatory T-cell function in acute and chronic liver disease. Gastroenterology. 1980 Oct;79(4):613–619. [PubMed] [Google Scholar]
  10. Kashio T., Hotta R., Kakumu S. Lymphocyte suppressor cell activity in acute and chronic liver disease. Clin Exp Immunol. 1981 Jun;44(3):459–466. [PMC free article] [PubMed] [Google Scholar]
  11. Mahdi S., Bopp E., Henke-Wolter J., von Stockhausen H. B. Zerebrale Blutung bei einem 4 Wochen alten Säugling mit homozytogem alpha 1-Antitrypsinmangel. Klin Padiatr. 1984 Mar-Apr;196(2):115–117. doi: 10.1055/s-2007-1025590. [DOI] [PubMed] [Google Scholar]
  12. McPherson K., Wennberg J. E., Hovind O. B., Clifford P. Small-area variations in the use of common surgical procedures: an international comparison of New England, England, and Norway. N Engl J Med. 1982 Nov 18;307(21):1310–1314. doi: 10.1056/NEJM198211183072104. [DOI] [PubMed] [Google Scholar]
  13. Miyawaki T., Moriya N., Nagaoki T., Taniguchi N. Maturation of B-cell differentiation ability and T-cell regulatory function in infancy and childhood. Immunol Rev. 1981;57:61–87. doi: 10.1111/j.1600-065x.1981.tb00442.x. [DOI] [PubMed] [Google Scholar]
  14. Preud'homme J. L., Flandrin G. Identification by peroxidase staining of monocytes in surface immunofluorescence tests. J Immunol. 1974 Nov;113(5):1650–1653. [PubMed] [Google Scholar]
  15. Reinherz E. L., Kung P. C., Goldstein G., Schlossman S. F. Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A. 1979 Aug;76(8):4061–4065. doi: 10.1073/pnas.76.8.4061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Shou L., Schwartz S. A., Good R. A. Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J Exp Med. 1976 May 1;143(5):1100–1110. doi: 10.1084/jem.143.5.1100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Vegnente A., Larcher V. F., Mowat A. P., Portmann B., Williams R. Duration of chronic active hepatitis and the development of cirrhosis. Arch Dis Child. 1984 Apr;59(4):330–335. doi: 10.1136/adc.59.4.330. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES