Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1985 Aug;61(2):323–328.

Common epitopes between mycobacterial and certain host tissue antigens.

C J Thorns, J A Morris
PMCID: PMC1577309  PMID: 2412744

Abstract

Monoclonal antibodies (MoAb) produced against a sonicated antigen extract of Mycobacterium bovis were examined for their ability to bind to 10 common tissue antigens. The binding patterns of MoAb MB2, MB3, MB7, MB11 and MB13 indicated that each recognized different epitopes. MoAb MB5 and MB17 failed to bind to any of the tissue antigens. MB3 reacted strongly with normal tissue from M. bovis infected guinea pigs and ferrets but there was no reaction with MB5 and MB17. These specificities were confirmed by reciprocal absorption experiments. It is concluded that Mycobacterium species contain epitopes that are also present in host tissue antigens.

Full text

PDF
323

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Drach G. W., Reed W. P., Williams R. C., Jr Antigens common to human and bacterial cells: urinary tract pathogens. J Lab Clin Med. 1971 Nov;78(5):725–735. [PubMed] [Google Scholar]
  2. Ellens D. J., Gielkens A. L. A simple method for the purification of 5-aminosalicylic acid. Application of the product as substrate in enzyme-linked immunosorbent assay (ELISA). J Immunol Methods. 1980;37(3-4):325–332. doi: 10.1016/0022-1759(80)90318-x. [DOI] [PubMed] [Google Scholar]
  3. Finne J., Leinonen M., Mäkelä P. H. Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis. Lancet. 1983 Aug 13;2(8346):355–357. doi: 10.1016/s0140-6736(83)90340-9. [DOI] [PubMed] [Google Scholar]
  4. Guilbert B., Dighiero G., Avrameas S. Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization. J Immunol. 1982 Jun;128(6):2779–2787. [PubMed] [Google Scholar]
  5. Holmgren J., Hanson L. A., Holm S. E., Kauser B. An antigenic relationship between kidney and certain Escherichia coli strains. Int Arch Allergy Appl Immunol. 1971;41(2):463–474. doi: 10.1159/000230540. [DOI] [PubMed] [Google Scholar]
  6. Lindqvist K. J., Coleman R. E., Osterland C. K. Autoantibodies in chronic pulmonary tuberculosis. J Chronic Dis. 1970 Apr;22(11):717–725. doi: 10.1016/0021-9681(70)90047-0. [DOI] [PubMed] [Google Scholar]
  7. Morris J. A., Stevens A. E., Sojka W. J. Preliminary characterization of cell-free K99 antigen isolated from Escherichia coli B41. J Gen Microbiol. 1977 Apr;99(2):353–357. doi: 10.1099/00221287-99-2-353. [DOI] [PubMed] [Google Scholar]
  8. Nakhla L. S., Glynn L. E. Studies on the antigen in beta-haemolytic streptococci that cross-reacts with an antigen in human myocardium. Immunology. 1967 Aug;13(2):209–218. [PMC free article] [PubMed] [Google Scholar]
  9. Stanford J. L., Beck A. An antigenic analysis of the mycobacteria, Mycobacterium fortuitum, Myco. kansasii, Myco. phlei, Myco. smegmatis and Myco. tuberculosis. J Pathol Bacteriol. 1968 Jan;95(1):131–139. doi: 10.1002/path.1700950116. [DOI] [PubMed] [Google Scholar]
  10. Stanford J. L., Rook G. A., Convit J., Godal T., Kronvall G., Rees R. J., Walsh G. P. Preliminary taxonomic studies on the leprosy bacillus. Br J Exp Pathol. 1975 Dec;56(6):579–585. [PMC free article] [PubMed] [Google Scholar]
  11. Stanford J. L., Wong J. K. A study of the relationship between Nocardia and Mycobacterium diernhoferi--a typical fast growing Mycobacterium. Br J Exp Pathol. 1974 Jun;55(3):291–295. [PMC free article] [PubMed] [Google Scholar]
  12. Thorns C. J., Morris J. A., Little T. W. A spectrum of immune responses and pathological conditions between certain animal species to experimental Mycobacterium bovis infection. Br J Exp Pathol. 1982 Oct;63(5):562–572. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES