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. 1986 Feb;63(2):303–311.

An unusual variant of T-CLL: evidence for the existence of a hitherto unrecognized T cell subset.

V E Moss, F Miedema, E Matutes, F Terpstra, A Brownell, M Brozovic, D Catovsky
PMCID: PMC1577366  PMID: 3486061

Abstract

A case of T-cell chronic lymphocytic leukaemia (T-CLL) with an unusual mature membrane phenotype: E+, CD3+, CD4+, CD8-, M1+, Leu-15+, Fc gamma+, is described. The cells were large granular lymphocytes with slight immature features. Functionally these cells lacked helper, suppressor and NK activity but possessed normal levels of K activity. These findings demonstrate several features not previously described in T-CLL: the coexpression of the antigens detected by T4, M1 and Leu-15 the presence of Fc gamma receptors on CD4+ lymphocytes and the lack of NK activity in M1+, Fc gamma+ cells. This study broadens the known heterogeneity of T-CLL and suggests the existence of a hitherto unrecognized normal T-lymphocyte subset with the same functional and phenotypic characteristics as in the case described here.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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