Abstract
This paper reports the results of in-vivo studies on the binding of intravenously injected cationised human IgM rheumatoid factor to glomeruli in mice. Evidence is presented to show that glomerular bound cationised IgM rheumatoid factor can act as an immunoabsorbent binding both endogenous immunoglobulin containing material from the circulation as well as intravenously injected immunoglobulins either in the form of aggregates or immune complexes.
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Selected References
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- Barnes J. L., Radnik R. A., Gilchrist E. P., Venkatachalam M. A. Size and charge selective permeability defects induced in glomerular basement membrane by a polycation. Kidney Int. 1984 Jan;25(1):11–19. doi: 10.1038/ki.1984.2. [DOI] [PubMed] [Google Scholar]
- Brownlee M., Pongor S., Cerami A. Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes. J Exp Med. 1983 Nov 1;158(5):1739–1744. doi: 10.1084/jem.158.5.1739. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Couser W. G., Salant D. J. In situ immune complex formation and glomerular injury. Kidney Int. 1980 Jan;17(1):1–13. doi: 10.1038/ki.1980.1. [DOI] [PubMed] [Google Scholar]
- Couser W. G., Steinmuller D. R., Stilmant M. M., Salant D. J., Lowenstein L. M. Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest. 1978 Dec;62(6):1275–1287. doi: 10.1172/JCI109248. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DIXON F. J., FELDMAN J. D., VAZQUEZ J. J. Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med. 1961 May 1;113:899–920. doi: 10.1084/jem.113.5.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ebling F., Hahn B. H. Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus. Comparison of antibodies in serum and renal eluates. Arthritis Rheum. 1980 Apr;23(4):392–403. doi: 10.1002/art.1780230402. [DOI] [PubMed] [Google Scholar]
- Ford P. M. Interaction of rheumatoid factor with immune complexes in experimental glomerulonephritis--possible role of antiglobulins in chronicity. J Rheumatol Suppl. 1983 Dec;11:81–84. [PubMed] [Google Scholar]
- Ford P. M., Kosataka I. The effect of human IgM rheumatoid factor on renal glomerular immune complex deposition in passive serum sickness in the mouse. Immunology. 1982 Aug;46(4):761–768. [PMC free article] [PubMed] [Google Scholar]
- Ford P. M., Kosatka I. In situ formation of antigen-antibody complexes in the mouse glomerulus. Immunology. 1979 Nov;38(3):473–479. [PMC free article] [PubMed] [Google Scholar]
- Ford P. M., Kosatka I. In situ immune complex formation in the mouse glomerulus: reactivity with human IgM rheumatoid factor and the effect on subsequent immune complex deposition. Clin Exp Immunol. 1983 Feb;51(2):285–291. [PMC free article] [PubMed] [Google Scholar]
- Ford P. M. Passive serum sickness in the mouse: effect of interstrain differences on glomerular deposition of immune complexes. Br J Exp Pathol. 1975 Jun;56(3):199–204. [PMC free article] [PubMed] [Google Scholar]
- Gallo G. R., Caulin-Glaser T., Lamm M. E. Charge of circulating immune complexes as a factor in glomerular basement membrane localization in mice. J Clin Invest. 1981 May;67(5):1305–1313. doi: 10.1172/JCI110159. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gauthier V. J., Mannik M., Striker G. E. Effect of cationized antibodies in performed immune complexes on deposition and persistence in renal glomeruli. J Exp Med. 1982 Sep 1;156(3):766–777. doi: 10.1084/jem.156.3.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
- IIO M., WAGNER H. N., Jr, SCHEFFEL U., JABBOUR B. Studies of the reticuloendothelial system (RES). I. Measurement of the phagocytic capacity of the RES in man and dog. J Clin Invest. 1963 Mar;42:417–426. doi: 10.1172/JCI104729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jalkanen M., Jalkanen S. Immunological detection of proteins after isoelectric focusing in thin layer agarose gel: a specific application for the characterization of immunoglobulin diversity. J Clin Lab Immunol. 1983 Apr;10(4):225–228. [PubMed] [Google Scholar]
- Lindström F. D., Hed J., Eneström S. Renal pathology of Waldenström's macroglobulinaemia with monoclonal antiglomerular antibodies and nephrotic syndrome. Clin Exp Immunol. 1980 Aug;41(2):196–204. [PMC free article] [PubMed] [Google Scholar]
- Maggiore Q., Bartolomeo F., L'Abbate A., Misefari V., Martorano C., Caccamo A., di Belgiojoso G. B., Tarantino A., Colasanti G. Glomerular localization of circulating antiglobulin activity in essential mixed cryoglobulinemia with glomerulonephritis. Kidney Int. 1982 Feb;21(2):387–394. doi: 10.1038/ki.1982.34. [DOI] [PubMed] [Google Scholar]
- McIntosh R. M., Rabideau D., Allen J. E., Garcia R., Rubio L., Carr R. I., Rodriguez-Iturbe B. Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. Ann Rheum Dis. 1979 Jun;38(3):257–261. doi: 10.1136/ard.38.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller K., Michael A. F. Immunopathology of renal extracellular membranes in diabetes mellitus. Specificity of tubular basement-membrane immunofluorescence. Diabetes. 1976 Aug;25(8):701–708. doi: 10.2337/diab.25.8.701. [DOI] [PubMed] [Google Scholar]
- Morel-Maroger L., Basch A., Danon F., Verroust P., Richet G. Pathology of the kidney in Waldenström's macroglobulinemia. Study of sixteen cases. N Engl J Med. 1970 Jul 16;283(3):123–129. doi: 10.1056/NEJM197007162830304. [DOI] [PubMed] [Google Scholar]
- Oite T., Batsford S. R., Mihatsch M. J., Takamiya H., Vogt A. Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted, cationized antigen. J Exp Med. 1982 Feb 1;155(2):460–474. doi: 10.1084/jem.155.2.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rossen R. D., Rickaway R. H., Reisberg M. A., Singer D. B., Schloeder F. X., Suki W. N., Hill L. L., Eknoyan G. Renal localization of antiglobulins in glomerulonephritis and after renal transplantation. Arthritis Rheum. 1977 May;20(4):947–961. doi: 10.1002/art.1780200407. [DOI] [PubMed] [Google Scholar]
- Rosén A., Ek K., Aman P. Agarose isoelectric focusing of native human immunoglobulin M and alpha 2-macroglobulin. J Immunol Methods. 1979;28(1-2):1–11. doi: 10.1016/0022-1759(79)90322-3. [DOI] [PubMed] [Google Scholar]
- Sela M., Mozes E. Dependence of the chemical nature of antibodies on the net electrical charge of antigens. Proc Natl Acad Sci U S A. 1966 Feb;55(2):445–452. doi: 10.1073/pnas.55.2.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stollar B. D., Stadecker M. J., Morecki S. Comparison of the inactivation of IgM and IgG complement fixation sites by acid and base. J Immunol. 1976 Oct;117(4):1387–1391. [PubMed] [Google Scholar]
- Tanimoto K., Cooper N. R., Johnson J. S., Vaughan J. H. Complement fixation by rheumatoid factor. J Clin Invest. 1975 Mar;55(3):437–445. doi: 10.1172/JCI107949. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Damme B. J., Fleuren G. J., Bakker W. W., Vernier R. L., Hoedemaeker P. J. Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest. 1978 Apr;38(4):502–510. [PubMed] [Google Scholar]
- Ward H. J., Cohen A. H., Border W. A. In situ formation of subepithelial immune complexes in the rabbit glomerulus: requirement of a cationic antigen. Nephron. 1984;36(4):257–264. doi: 10.1159/000183165. [DOI] [PubMed] [Google Scholar]
