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. 1985 Oct;62(1):193–199.

Suppression of IgE synthesis in vitro by allogeneic T cells from atopic and non-atopic subjects.

J J Zaunders, D A Cooper, Y Young, M Duckett, R Penny, J B Ziegler
PMCID: PMC1577403  PMID: 2933197

Abstract

The role of T cells in the regulation of IgE synthesis by human PBMC was studied. PBMC or separated and recombined populations of T and B cells from both normal and atopic donors were cultured for 10 days with and without cycloheximide. IgE and IgG synthesis were determined by specific RIA. IgE synthesis was detected in 0/30 non-atopic, 6/34 mildly atopic and 25/31 severely atopic subjects. Autologous T cells from 10/26 atopic donors, whose B cells synthesised IgE, significantly suppressed this IgE synthesis. The addition of allogeneic T cells from atopic or non-atopic subjects to atopic B cells resulted in greater suppression of IgE synthesis than the addition of autologous T cells. These data support the notion that atopic subjects have naturally occurring IgE isotype-specific suppressor T cells as well as suppressor T cells which can be activated during incubation with alloantigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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