Abstract
A new antipruritic, trimeprazine, was used in the treatment of itching associated with a variety of dermatologic disorders in 215 patients.
Good to excellent relief of itching was experienced by 71 per cent of the patients, fair relief by 15 per cent and poor relief by 14 per cent.
Side effects included mild and transient drowsiness or dizziness that cleared spontaneously; six cases of drowsiness that necessitated discontinuance of the drug; three cases of drowsiness that was controlled by reduction of the dosage; and one case of generalized eruption that cleared upon discontinuance of the drug.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CALLAWAY J. L., OLANSKY S. Trimeprazine: an adjuvant in the management of itching dermatoses. N C Med J. 1957 Aug;18(8):320–321. [PubMed] [Google Scholar]
- PARRATT J. R., WEST G. B. Inhibition by various substances of oedema formation in the bind-paw of the rat induced by 5-hydroxytryptamine, histamine, dextran, egg-white and compound 48/80. Br J Pharmacol Chemother. 1958 Mar;13(1):65–70. doi: 10.1111/j.1476-5381.1958.tb00192.x. [DOI] [PMC free article] [PubMed] [Google Scholar]