Abstract
Phytohaemagglutinin (PHA) was found to suppress both the primary and secondary immune response to mammalian and avian erythrocytes in rats and mice. Effective suppression of humoral antibody production occurred when PHA was administered prior to or a few hours after immunization. PHA also induced the appearance of naturally occurring antibody in low titre in unimmunized animals. Variable results were obtained in a study of suppression of humoral antibody production to bacterial antigens. No effect of PHA could be detected on the development of experimental thyroiditis in guinea-pigs.
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Selected References
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