Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1967 Jul;2(4):489–495.

Discoid lupus erythematosus at the site of an intradermal injection of killed staphylococcus aureus

Katherine Grice, Deborah Doniach, J L Turk
PMCID: PMC1578865  PMID: 6052544

Abstract

A case of chronic discoid lupus erythematosus is described in which there were recurrent relapses following infections, and at the same time repeated `flare ups' at the site of a delayed hypersensitivity reaction to Staphylococcus aureus. The appearance of the injection site changed from that of a typical `tuberculin reaction' to a patch of discoid lypus erythematosus which was confirmed both histologically and by immunofluorescence.

Full text

PDF
489

Images in this article

490Fig. 1
on p.490
492Fig. 2
on p.492
493Fig. 3
on p.493
493Fig. 4
on p.493

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALARCON SEGOVIA D., GALBRAITH R. F., MALDONADO J. E., HOWARD F. M., Jr SYSTEMIC LUPUS ERYTHEMATOSUS FOLLOWING THYMECTOMY FOR MYSTHENIA GRAVIS. REPORT OF TWO CASES. Lancet. 1963 Sep 28;2(7309):662–665. doi: 10.1016/s0140-6736(63)90456-2. [DOI] [PubMed] [Google Scholar]
  2. BURNHAM T. K., NEBLETT T. R., FINE G. THE APPLICATION OF THE FLUORESCENT ANTIBODY TECHNIC TO THE INVESTIGATION OF LUPUS ERYTHEMATOSUS AND VARIOUS DERMATOSES. J Invest Dermatol. 1963 Dec;41:451–456. doi: 10.1038/jid.1963.140. [DOI] [PubMed] [Google Scholar]
  3. CORMANE R. H. "BOUND" GLOBULIN IN THE SKIN OF PATIENTS WITH CHRONIC DISCOID LUPUS ERYTHEMATOSUS AND SYSTEMIC LUPUS ERYTHEMATOSUS. Lancet. 1964 Mar 7;1(7332):534–535. doi: 10.1016/s0140-6736(64)92917-4. [DOI] [PubMed] [Google Scholar]
  4. DOMZ C. A., McNAMARA D. H., HOLZAPFEL H. F. Tetracycline provocation in lupus erythematosus. Ann Intern Med. 1959 May;50(5):1217–1226. doi: 10.7326/0003-4819-50-5-1217. [DOI] [PubMed] [Google Scholar]
  5. GOLD S. C., GOWING N. F. Systemic lupus erythematosus; a clinical and pathological study. Q J Med. 1953 Oct;22(88):457–481. [PubMed] [Google Scholar]
  6. HIJMANS W., DONIACH D., ROITT I. M., HOLBOROW E. J. Serological overlap between lupus erythematosus, rheumatoid arthritis, and thyroid auto-immune disease. Br Med J. 1961 Oct 7;2(5257):909–914. doi: 10.1136/bmj.2.5257.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KALSBEEK G. L., CORMANE R. H. "BOUND" COMPLEMENT IN THE SKIN OF PATIENTS WITH CHRONIC DISCOID LUPUS ERYTHEMATOSUS AND SYSTEMIC LUPUS ERYTHEMATOSUS. Lancet. 1964 Jul 25;2(7352):178–180. doi: 10.1016/s0140-6736(64)90234-x. [DOI] [PubMed] [Google Scholar]
  8. MUND A., SIMSON J., ROTHFIELD N. Effect of pregnancy on course of systemic lupus erythematosus. JAMA. 1963 Mar 16;183:917–920. doi: 10.1001/jama.1963.03700110049009. [DOI] [PubMed] [Google Scholar]
  9. ROBURN M. LYSOSOMES, AUTOIMMUNE PHENOMENA, AND DISEASES OF CONNECTIVE TISSUE. Lancet. 1965 Jan 9;1(7376):112–112. doi: 10.1016/s0140-6736(65)91706-x. [DOI] [PubMed] [Google Scholar]
  10. SHRANK A. B., DONIACH D. Discoid lupus erythematosus. Correlation of clinical features with serum auto-antibody pattern. Arch Dermatol. 1963 Jun;87:677–685. doi: 10.1001/archderm.1963.01590180005001. [DOI] [PubMed] [Google Scholar]
  11. STEVENS K. M. THE AETIOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS. Lancet. 1964 Sep 5;2(7358):506–508. doi: 10.1016/s0140-6736(64)90458-1. [DOI] [PubMed] [Google Scholar]
  12. Tan E. M., Kunkel H. G. An immunofluorescent study of the skin lesions in systemic lupus erythematosus. Arthritis Rheum. 1966 Feb;9(1):37–46. doi: 10.1002/art.1780090105. [DOI] [PubMed] [Google Scholar]
  13. Varelzidis A., Turk J. L. Significance of reactions to intradermal injection of autologous granulocytes, mononuclear cells, and serum. Br Med J. 1966 Aug 13;2(5510):379–382. doi: 10.1136/bmj.2.5510.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. WEISSMANN G. LYSOSOMES, AUTOIMMUNE PHENOMENA, AND DISEASES OF CONNECTIVE TISSUE. Lancet. 1964 Dec 26;2(7374):1373–1375. doi: 10.1016/s0140-6736(64)91163-8. [DOI] [PubMed] [Google Scholar]
  15. WHITBY J. L., BLACK H. J. COMPARISON OF LYMECYCLINE WITH TETRACYCLINE HYDROCHLORIDE. Br Med J. 1964 Dec 12;2(5423):1491–1495. doi: 10.1136/bmj.2.5423.1491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. ZINGALE S. B., MINZER L., ROSENBERG B., LEE S. L. Drug induced lupus-like syndrome. Clinical and laboratory syndrome similar to systemic lupus erythematosus following antituberculous therapy: report of a case. Arch Intern Med. 1963 Jul;112:63–66. doi: 10.1001/archinte.1963.03860010109012. [DOI] [PubMed] [Google Scholar]
  17. ten Have-Opbroek A. A. [On the differential diagnosis between chronic discoid lupus erythematodes and lymphocytic infiltration of the skin (Jessner), with emphasis on fluorescence microscopy]. Dermatologica. 1966;132(2):109–114. doi: 10.1159/000254409. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES