Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1967 Jul;2(4):427–443.

Malignant changes in New Zealand black mice

June East, Maria A B de Sousa, Patricia R Prosser, H Jaquet
PMCID: PMC1578867  PMID: 4167748

Abstract

Ageing, Coombs positive, NZB mice, may spontaneously develop a neoplasia of the reticulum cell type which can be transferred by serial passage of their lymphoid tissues in young intact or neonatally thymectomized syngeneic recipients. The recipients (103/117) of cell suspensions prepared from the enlarged spleens and/or lymph nodes of four such donors developed an extensive and lethal reticulum cell neoplasia affecting the spleen, lymph nodes, lungs and liver but the bone marrow, thymus and kidneys were seldom involved. The recipients (16/17) of spleen cells from a fifth donor showed massive proliferations of eosinophils in all the organs examined.

Prematurely positive antiglobulin (Coombs) reactions were detected in only two recipients. Although there was an indication that the IgM content of the sera decreased as one of the passages progressed, the levels of IgG and IgA were not seriously distorted.

Particles resembling murine leukaemia virus were identified by electron microscopy in the spleen and in plasma or serum pellets of passage recipients. However, similar particles were also seen in the thymus and/or spleen or bone marrow of untreated NZB mice including an 18-day embryo and animals aged 1–56 weeks, although no particles were found in plasma and serum pellets of mice aged 6–70 weeks.

The theory that autoimmunity, malignancy and virus infection are directly related is discussed.

Full text

PDF
427

Images in this article

433Fig. 1
on p.433
433Fig. 2
on p.433
434Fig. 3-4
on p.434
435Fig. 5
on p.435
436Fig. 6
on p.436
437Fig. 7
on p.437
438Fig. 8
on p.438
439Fig. 9
on p.439

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNET F. M., HOLMES M. C. THYMIC CHANGES IN THE MOUSE STRAIN NZB IN RELATION TO THE AUTO-IMMUNE STATE. J Pathol Bacteriol. 1964 Jul;88:229–241. doi: 10.1002/path.1700880129. [DOI] [PubMed] [Google Scholar]
  2. EAST J., PARROT D. M. Operative techniques for newborn mice using anaesthesia by cooling. J Endocrinol. 1962 Apr;24:249–250. doi: 10.1677/joe.0.0240249. [DOI] [PubMed] [Google Scholar]
  3. EAST J., PARROTT D. M., CHESTERMAN F. C., POMERANCE A. THE APPEARANCE OF A HEPATOTROPHIC VIRUS IN MICE THYMECTOMIZED AT BIRTH. J Exp Med. 1963 Dec 1;118:1069–1082. doi: 10.1084/jem.118.6.1069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. East J., De Sousa M. A. The thymus autoimmunity and malignancy in New Zealand black mice. Natl Cancer Inst Monogr. 1966 Sep;22:605–616. [PubMed] [Google Scholar]
  5. East J., de Sousa M. A., Parrott D. M. Immunopathology of New Zealand black (NZB) mice. Transplantation. 1965 Nov;3(6):711–729. doi: 10.1097/00007890-196511000-00003. [DOI] [PubMed] [Google Scholar]
  6. FAHEY J. L., WUNDERLICH J., MISHELL R. THE IMMUNOGLOBULINS OF MICE. I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S GAMMA-2-, 7S GAMMA-1-, GAMMA-1A (BETA-2A)-, AND 18S GAMMA-1M-GLOBULINS. J Exp Med. 1964 Aug 1;120:223–242. doi: 10.1084/jem.120.2.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GELL P. G. The estimation of the individual human serum proteins by an immunological method. J Clin Pathol. 1957 Feb;10(1):67–71. doi: 10.1136/jcp.10.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HELYER B. J., HOWIE J. B. Spontaneous auto-immune disease in NZB/BL mice. Br J Haematol. 1963 Apr;9:119–131. doi: 10.1111/j.1365-2141.1963.tb05450.x. [DOI] [PubMed] [Google Scholar]
  9. HOLMES M. C., BURNET F. M. EXPERIMENTAL STUDIES OF THYMIC FUNCTION IN NZB MICE AND THE F1 HYBRIDS WITH C3H. Aust J Exp Biol Med Sci. 1964 Oct;42:589–600. doi: 10.1038/icb.1964.55. [DOI] [PubMed] [Google Scholar]
  10. HOLMES M. C., BURNET F. M. THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS. Ann Intern Med. 1963 Sep;59:265–276. doi: 10.7326/0003-4819-59-3-265. [DOI] [PubMed] [Google Scholar]
  11. LONG G., HOLMES M. C., BURNET F. M. AUTOANTIBODIES PRODUCED AGAINST MOUSE ERYTHROCYTES IN NZB MICE. Aust J Exp Biol Med Sci. 1963 Aug;41:315–322. doi: 10.1038/icb.1963.31. [DOI] [PubMed] [Google Scholar]
  12. MELLORS R. C. AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS. J Exp Med. 1965 Jul 1;122:25–40. doi: 10.1084/jem.122.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mellors R. C. Autoimmune disease in NZB-Bl mice. II. Autoimmunity and malignant lymphoma. Blood. 1966 Apr;27(4):435–448. [PubMed] [Google Scholar]
  14. Parrott D. V., De Sousa M. A., East J. Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J Exp Med. 1966 Jan 1;123(1):191–204. doi: 10.1084/jem.123.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
  16. Stanley N. F., Walters N. M. Virus induction autoimmune disease and neoplasia. Lancet. 1966 Apr 30;1(7444):962–963. doi: 10.1016/s0140-6736(66)90956-1. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES