Abstract
Blood lymphocytes from twenty-four patients with rheumatoid arthritis and twenty-two controls were incubated on monolayers of human fibroblasts in a serum-free medium. Lymphocytes from nineteen of the rheumatoid patients caused severe damage to the fibroblasts within 72 hr. The findings support the idea that sensitized lymphocytes play an important role in the pathogenesis of rheumatoid arthritis. The in vitro test may be useful in clinical practice in distinguishing rheumatoid from non-rheumatoid arthritis.
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- BERG O., KAELLEN B. EFFECT OF MONONUCLEAR BLOOD CELLS FROM MULTIPLE SCLEROSIS PATIENTS ON NEUROGLIA IN TISSUE CULTURE. J Neuropathol Exp Neurol. 1964 Jul;23:550–559. doi: 10.1097/00005072-196407000-00010. [DOI] [PubMed] [Google Scholar]
- BRAUNSTEINER H., DIENSTL F., EIBL M. DESTRUCTIVE EFFECT OF LYMPHNODE CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS IN TISSUE CULTURE. Acta Haematol. 1964 Apr;31:225–229. doi: 10.1159/000209631. [DOI] [PubMed] [Google Scholar]
- GOVAERTS A. Cellular antibodies in kidney homotransplantation. J Immunol. 1960 Nov;85:516–522. [PubMed] [Google Scholar]
- HEDBERG H., KAELLEN B. STUDIES ON MONONUCLEAR CELLS OBTAINED FROM SYNOVIAL FLUID OF PATIENTS WITH DIFFERENT TYPES OF ARTHRITIS. CYTOTOXIC EFFECT ON TISSUE-CULTURED HUMAN FIBROBLASTS. Acta Pathol Microbiol Scand. 1964;62:177–188. doi: 10.1111/apm.1964.62.2.177. [DOI] [PubMed] [Google Scholar]
- PERLMANN P., BROBERGER O. In vitro studies of ulcerative colitis. II. Cytotoxic action of white blood cells from patients on human fetal colon cells. J Exp Med. 1963 May 1;117:717–733. doi: 10.1084/jem.117.5.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pegg P. J. The preservation of leucocytes for cytogenetic and cytochemical studies. Br J Haematol. 1965 Sep;11(5):586–591. doi: 10.1111/j.1365-2141.1965.tb00103.x. [DOI] [PubMed] [Google Scholar]
- ROSENAU W., MOON H. D. Lysis of homologous cells by sensitized lymphocytes in tissue culture. J Natl Cancer Inst. 1961 Aug;27:471–483. [PubMed] [Google Scholar]
- Trayanova T. G., Sura V. V., Svet-Moldavsky G. J. Destruction of human cells in tissue culture by lymphocytes from patients with systemic lupus erythematosus. Lancet. 1966 Feb 26;1(7435):452–454. doi: 10.1016/s0140-6736(66)91456-5. [DOI] [PubMed] [Google Scholar]
- WILSON D. B. THE REACTION OF IMMUNOLOGICALLY ACTIVATED LYMPHOID CELLS AGAINST HOMOLOGOUS LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET TISSUE CELLS IN VITRO. J Cell Physiol. 1963 Dec;62:273–286. doi: 10.1002/jcp.1030620307. [DOI] [PubMed] [Google Scholar]