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. 1968 Jan;3(1):99–105.

Induction by isoniazid and hydrallazine of antinuclear factors in mice

Arlette Cannat, M Seligmann
PMCID: PMC1578896  PMID: 5300375

Abstract

The long-term oral administration of isoniazid and hydrallazine to mice resulted in a significant increase in the incidence of antinuclear factors (ANF) in C57B1/6 for both drugs and BALB/c for hydrallazine. ANF disappeared in some mice 2 months after the drugs were discontinued. These findings and the differences observed according to strain, sex and age are discussed in relation to human SLE-like syndromes which may possibly be induced or triggered by drugs.

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Selected References

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  1. ALARCON SEGOVIA D., WORTHINGTON J. W., WARD L. E., WAKIM K. G. LUPUS DIATHESIS AND THE HYDRALAZINE SYNDROME. N Engl J Med. 1965 Mar 4;272:462–466. doi: 10.1056/NEJM196503042720905. [DOI] [PubMed] [Google Scholar]
  2. BRAVERMAN I. M., LERNER A. B. Hydralazine disease in the guinea-pig as an experimental model for lupus erythematosus. J Invest Dermatol. 1962 Oct;39:317–327. doi: 10.1038/jid.1962.119. [DOI] [PubMed] [Google Scholar]
  3. Brézin C., Cannat A., Sekiguchi M. Présence d'anticorps sériques antinucléaires chez des souris thymectomisées a la naissance. Rev Fr Etud Clin Biol. 1965 Oct;10(8):839–841. [PubMed] [Google Scholar]
  4. COMENS P. Experimental hydralazine disease and its similarity to disseminated lupus erythematosus. J Lab Clin Med. 1956 Mar;47(3):444–454. [PubMed] [Google Scholar]
  5. Cannat A., Seligmann M. Possible induction of antinuclear antibodies by isoniazid. Lancet. 1966 Jan 22;1(7430):185–187. doi: 10.1016/s0140-6736(66)90704-5. [DOI] [PubMed] [Google Scholar]
  6. Condemi J. J., Moore-Jones D., Vaughan J. H., Perry H. M. Antinuclear antibodies following hydralazine toxicity. N Engl J Med. 1967 Mar 2;276(9):486–491. doi: 10.1056/NEJM196703022760902. [DOI] [PubMed] [Google Scholar]
  7. DUBOIS E. L., KATZ Y. J., FREEMAN V., GARBAK F. Chronic toxicity studies of hydralazine (apresoline) in dogs with particular reference to the production of the hydralazine syndrome. J Lab Clin Med. 1957 Jul;50(1):119–126. [PubMed] [Google Scholar]
  8. FRIOU G. J., TEAGUE P. O. SPONTANEOUS AUTOIMMUNITY IN MICE: ANTIBODIES TO NUCLEOPROTEIN IN STRAIN A-J. Science. 1964 Mar 20;143(3612):1333–1334. [PubMed] [Google Scholar]
  9. HAMARD M., CANNAT A., SELIGMANN M. LA RECHERCHE D'ANTICORPS ANTI-NUCL'EAIRES PAR IMMUNOFLUORESCENCE. (ETUDE DE 1430 S'ERUMS) Rev Fr Etud Clin Biol. 1964 Aug-Sep;9:716–728. [PubMed] [Google Scholar]
  10. HOLLEY H. L. EVIDENCE FOR A PREDISPOSITION TO RHEUMATIC DISEASES IN FAMILIES OF PATIENTS DEVELOPING DRUG-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS. Arthritis Rheum. 1964 Dec;7:684–686. doi: 10.1002/art.1780070608. [DOI] [PubMed] [Google Scholar]
  11. LONG G., HOLMES M. C., BURNET F. M. AUTOANTIBODIES PRODUCED AGAINST MOUSE ERYTHROCYTES IN NZB MICE. Aust J Exp Biol Med Sci. 1963 Aug;41:315–322. doi: 10.1038/icb.1963.31. [DOI] [PubMed] [Google Scholar]
  12. Lee S. L., Rivero I., Siegel M. Activation of systemic lupus erythematosus by drugs. Arch Intern Med. 1966 May;117(5):620–626. [PubMed] [Google Scholar]
  13. MOLLERBERG H. Attempts to produce the hydralazine syndrome in the albino rat. Acta Med Scand. 1958 Aug 23;161(6):443–445. [PubMed] [Google Scholar]
  14. MONIER J. C. [Collagenosis after hydrazine administration in the rat]. Alger Medicale. 1960 May;64:421–426. [PubMed] [Google Scholar]
  15. McCOY F. W., LEACH W. J. Experimental attempt to produce L-E syndrome (arthritis) in swine with hydralazine. Proc Soc Exp Biol Med. 1959 May;101(1):183–183. doi: 10.3181/00379727-101-24875. [DOI] [PubMed] [Google Scholar]
  16. NORINS L. C., HOLMES M. C. ANTINUCLEAR FACTOR IN MICE. J Immunol. 1964 Jul;93:148–154. [PubMed] [Google Scholar]
  17. Peacock A., Peacock P. R. The results of prolonged administration of isoniazid to mice, rats and hamsters. Br J Cancer. 1966 Jun;20(2):307–325. doi: 10.1038/bjc.1966.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SIGUIER F., BETOURNE C., BONNET DE LA TOUR J. Le lupus érythémateux hydralazinique. Sem Hop. 1958 Mar 18;34(13/3):773–84SP. [PubMed] [Google Scholar]
  19. ZINGALE S. B., MINZER L., ROSENBERG B., LEE S. L. Drug induced lupus-like syndrome. Clinical and laboratory syndrome similar to systemic lupus erythematosus following antituberculous therapy: report of a case. Arch Intern Med. 1963 Jul;112:63–66. doi: 10.1001/archinte.1963.03860010109012. [DOI] [PubMed] [Google Scholar]

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