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. 1968 Jan;3(1):1–16.

Antibodies to salivary duct cells, and other autoantibodies, in patients with Sjögren's syndrome and other idiopathic autoimmune diseases

T E W Feltkamp, A L van Rossum
PMCID: PMC1578900  PMID: 4171044

Abstract

Sera from thirty patients with Sjögren's syndrome were studied for the presence of antibodies to salivary duct cells. In sixteen cases (53%) a positive result was obtained.

The antibodies were present in the IgG globulins, in the IgM globulins also in nearly 50% of the IgG-positive cases, and rarely in the IgA globulins. One-third of the antibodies proved to be complement-fixing. No antibodies were found in normal controls matched for sex and age.

An antinuclear factor (ANF) was demonstrated in 77% of the sera. A rheumatoid factor was shown in 48% of the sera using a modified Waaler–Rose test and in 100% using a Latex fixation test. Antibodies to smooth muscle were present in 19%. Antibodies to skeletal muscle, gastric parietal cells, thyroid antigens, adrenocortex and mitochondria were found in frequencies which did not differ significantly from those in matched controls.

No correlation was demonstrated between antibodies to salivary duct cells and any of the other antibodies mentioned. Antibodies to salivary duct cells could only be absorbed with salivary gland tissue and not with other tissues. Antibodies to salivary duct cells were also found in patients with rheumatoid arthritis (22%), systemic lupus erythematosus (SLE) (18%) and myasthenia gravis (11%). They were extremely rare in patients with pernicious anaemia, autoimmune thyroiditis and idiopathic adrenocortical insufficiency. The antibodies could not be confirmed as being directed against the patient's own parotid tissue, probably due to loss of antigenic determinants as a result of the disease process. However, other findings support the opinion that Sjögren's syndrome is an idiopathic autoimmune disease.

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Selected References

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  1. BECK J. S., ANDERSON J. R., BLOCH K. J., BUCHANAN W. W., BUNIM J. J. ANTINUCLEAR AND PRECIPITATING AUTO-ANTIBODIES IN SJOEGREN'S SYNDROME. Ann Rheum Dis. 1965 Jan;24:16–22. doi: 10.1136/ard.24.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BERTRAM U., HALBERG P. A SPECIFIC ANTIBODY AGAINST THE EPITHELIUM OF THE SALIVARY DUCTS IN SERA FROM PATIENTS WITH SJOEGREN'S SYNDROME. Acta Allergol. 1964;19:458–466. doi: 10.1111/j.1398-9995.1964.tb03284.x. [DOI] [PubMed] [Google Scholar]
  3. BLIZZARD R. M., CHANDLER R. W., KYLE M. A., HUNG W. Adrenal antibodies in Addison's disease. Lancet. 1962 Nov 3;2(7262):901–903. doi: 10.1016/s0140-6736(62)90681-5. [DOI] [PubMed] [Google Scholar]
  4. BLOCH K. J., BUCHANAN W. W., WOHL M. J., BUNIM J. J. SJOEGREN'S SYNDROME. A CLINICAL, PATHOLOGICAL, AND SEROLOGICAL STUDY OF SIXTY-TWO CASES. Medicine (Baltimore) 1965 May;44:187–231. [PubMed] [Google Scholar]
  5. Bertram U., Halberg P. Organ antibodies in Sjögren's syndrome. Acta Allergol. 1965;20(6):472–483. doi: 10.1111/j.1398-9995.1965.tb03082.x. [DOI] [PubMed] [Google Scholar]
  6. CHAN W. C. EXPERIMENTAL SIALO-ADENITIS IN GUINEA-PIGS. J Pathol Bacteriol. 1964 Oct;88:592–595. doi: 10.1002/path.1700880227. [DOI] [PubMed] [Google Scholar]
  7. Doniach D., Roitt I. M., Walker J. G., Sherlock S. Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications. Clin Exp Immunol. 1966 Jul;1(3):237–262. [PMC free article] [PubMed] [Google Scholar]
  8. FELTKAMP T. E., van der GELD, OOSTERHUIS H. J. Studies on sera from cases of myasthenia gravis, using the fluorescent antibody technique. Vox Sang. 1963 May-Jun;8:317–327. [PubMed] [Google Scholar]
  9. Feltkamp T. E., Kruyff K., Ladiges N. C., Rümke P. Autospermagglutinins: immunofluorescent studies. Ann N Y Acad Sci. 1965 Jun 30;124(2):702–708. doi: 10.1111/j.1749-6632.1965.tb18996.x. [DOI] [PubMed] [Google Scholar]
  10. Halberg P., Bertram U., Soborg M., Nerup J. Organ antibodies in disseminated lupus erythematosus. Acta Med Scand. 1965 Sep;178(3):291–299. doi: 10.1111/j.0954-6820.1965.tb04273.x. [DOI] [PubMed] [Google Scholar]
  11. Irvine W. J., Stewart A. G., Scarth L. A clinical and immunological study of adrenocortical insufficiency (Addison's disease). Clin Exp Immunol. 1967 Jan;2(1):31–70. [PMC free article] [PubMed] [Google Scholar]
  12. JOHNSON G. D. Simplified procedure for removing nonspecific staining components from fluorescein-labelled conjugates. Nature. 1961 Jul 1;191:70–71. doi: 10.1038/191070a0. [DOI] [PubMed] [Google Scholar]
  13. Johnson G. D., Holborow E. J., Glynn L. E. Antibody to smooth muscle in patients with liver disease. Lancet. 1965 Oct 30;2(7418):878–879. doi: 10.1016/s0140-6736(65)92505-5. [DOI] [PubMed] [Google Scholar]
  14. KELLGREN J. H. Diagnostic criteria for population studies. Bull Rheum Dis. 1962 Nov;13:291–292. [PubMed] [Google Scholar]
  15. MARSHALL J. D., EVELAND W. C., SMITH C. W. Superiority of fluorescein isothiocyanate (Riggs) for fluorescent-antibody technic with a modification of its application. Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):898–900. doi: 10.3181/00379727-98-24222. [DOI] [PubMed] [Google Scholar]
  16. MacSween R. N., Goudie R. B., Anderson J. R., Armstrong E., Murray M. A., Mason D. K., Jasani M. K., Boyle J. A., Buchanan W. W., Williamson J. Occurrence of antibody to salivary duct epithelium in Sjogren's disease, rheumatoid arthritis, and other arthritides. A clinical and laboratory study. Ann Rheum Dis. 1967 Sep;26(5):402–411. doi: 10.1136/ard.26.5.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. OOSTERHUIS H. J. STUDIES IN MYASTHENIA GRAVIS. 1. A CLINICAL STUDY OF 180 PATIENTS. J Neurol Sci. 1964 Nov-Dec;1(6):512–546. doi: 10.1016/0022-510x(64)90171-6. [DOI] [PubMed] [Google Scholar]
  18. Strauss A. J., Kemp P. G., Douglas S. D. Myasthenia gravis. Lancet. 1966 Apr 2;1(7440):772–773. doi: 10.1016/s0140-6736(66)90931-7. [DOI] [PubMed] [Google Scholar]
  19. Talal N. Sjögren's syndrome. Bull Rheum Dis. 1966 Mar;16(7):404–407. [PubMed] [Google Scholar]
  20. WALKER J. G., DONIACH D., ROITT I. M., SHERLOCK S. SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS. Lancet. 1965 Apr 17;1(7390):827–831. doi: 10.1016/s0140-6736(65)91372-3. [DOI] [PubMed] [Google Scholar]
  21. WATERHOUSE J. P. FOCAL ADENITIS IN SALIVARY AND LACRIMAL GLANDS. Proc R Soc Med. 1963 Oct;56:911–918. [PMC free article] [PubMed] [Google Scholar]
  22. Whittingham S., Irwin J., Mackay I. R., Smalley M. Smooth muscle autoantibody in "autoimmune" hepatitis. Gastroenterology. 1966 Oct;51(4):499–505. [PubMed] [Google Scholar]
  23. Wright R., Kerr J. H. Autoimmunity in myasthenia gravis: a family study. Clin Exp Immunol. 1967 Jan;2(1):93–101. [PMC free article] [PubMed] [Google Scholar]

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