Abstract
A group of sera from hospital patients and normal subjects has been tested for the presence of antinuclear antibodies, and the amount of labile inhibitor to desoxyribonuclease 1 present in each of the sera estimated. It has been found that the presence of antinuclear antibodies is associated with a high level of inhibitor to a statistically significant degree.
It has also been found that this inhibitor is formed during the clotting of whole blood and that it is derived from platelets. A possible relationship between the inhibitor, its formation during the clotting of blood, and the characteristic presence of antinuclear antibodies in systemic lupus erythematosus is discussed.
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Selected References
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- FEINSTEIN R. N., GREEN F. O. An activator of deoxyribonuclease in rat plasma. Arch Biochem Biophys. 1956 Feb;60(2):502–504. doi: 10.1016/0003-9861(56)90458-1. [DOI] [PubMed] [Google Scholar]
- FEINSTEI R. N. Activation of the neutral deoxyribonuclease. J Biol Chem. 1960 Mar;235:733–737. [PubMed] [Google Scholar]
- GUPTA S., HERRIOTT R. M. Nucleases and their inhibitors in the cellular components of human blood. Arch Biochem Biophys. 1963 Apr;101:88–95. doi: 10.1016/0003-9861(63)90538-1. [DOI] [PubMed] [Google Scholar]
- HENSTELL H. H., FREEDMAN R. I. The viscosimetric determination of desoxyribonuclease inhibition. Cancer Res. 1952 May;12(5):341–345. [PubMed] [Google Scholar]
- HUMPHREY J. H., JAQUES R. The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reactions (in vitro). J Physiol. 1955 Apr 28;128(1):9–27. doi: 10.1113/jphysiol.1955.sp005289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JOHNSON A. J., GOGER P. R., TILLETT W. S. The intravenous injection of bovine crystalline pancreatic desoxyribonuclease into patients. J Clin Invest. 1954 Dec;33(12):1670–1686. doi: 10.1172/JCI103048. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KURNICK N. B., SCHWARTZ L. I., PARISER S., LEE S. L. A specific inhibitor for human desoxyribonuclease and an inhibitor of the lupus erythematosus cell phenomenon from leucocytes. J Clin Invest. 1953 Mar;32(3):193–201. doi: 10.1172/JCI102727. [DOI] [PMC free article] [PubMed] [Google Scholar]