Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1968 Jun;3(5):413–421.

Factors influencing the immune response. III. The blocking effect of Corynebacterium parvum upon the induction of acquired immunological unresponsiveness to bovine serum albumin in the adult rabbit

R N Pinckard, D M Weir, W H McBride
PMCID: PMC1578909  PMID: 5301938

Abstract

The intravenous injection of 10 mg aggregate-free, centrifuged bovine albumin into adult rabbits has been shown to induce an unresponsive state to bovine serum albumin (BSA) in the majority of rabbits. An intravenous injection of 15 mg of a heat-killed suspension of Corynebacterium parvum either 6 days prior to or simultaneously with centrifuged bovine albumin has been shown to significantly block the induction of unresponsiveness to BSA. Some effects of C. parvum upon the lymphoreticular tissues in the rabbit are reported.

Full text

PDF

Images in this article

417Fig. 1
on p.417
418Fig. 2
on p.418

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIRO C. E., GARCIA G. THE ANTIGENICITY OF AGGREGATED AND AGGREGATE-FREE HUMAN GAMMA-GLOBULIN FOR RABBITS. Immunology. 1965 Apr;8:411–419. [PMC free article] [PubMed] [Google Scholar]
  2. CLAMAN H. N. TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS. J Immunol. 1963 Dec;91:833–839. [PubMed] [Google Scholar]
  3. Claman H. N., Bronsky E. A. Inhibition of antibody production and acquired immunologic tolerance by actinomycin. J Immunol. 1965 Oct;95(4):718–721. [PubMed] [Google Scholar]
  4. DRESSER D. W. Specific inhibition of antibody production. I. Protein-over loading paralysis. Immunology. 1962 Jan;5:161–168. [PMC free article] [PubMed] [Google Scholar]
  5. DRESSER D. W. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology. 1962 May;5:378–388. [PMC free article] [PubMed] [Google Scholar]
  6. FARR R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. doi: 10.1093/infdis/103.3.239. [DOI] [PubMed] [Google Scholar]
  7. Gery I., Waksman B. H. Role of the thymus in tolerance. V. Suppressive effect of treatment with nonaggregated and aggregated bovine gamma-globulin on specific immune responses in normal adult rats. J Immunol. 1967 Mar;98(3):446–460. [PubMed] [Google Scholar]
  8. Golub E. S., Weigle W. O. Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol. 1967 Jun;98(6):1241–1247. [PubMed] [Google Scholar]
  9. Golub E. S., Weigle W. O. Studies on the induction of immunologic unresponsiveness. II. Kinetics. J Immunol. 1967 Sep;99(3):624–628. [PubMed] [Google Scholar]
  10. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  11. Pinckard R. N., McBride W. H., Weir D. M. Sensitivity and detection of 19S antibody by the Farr technique. Nature. 1967 Sep 2;215(5105):1084–1085. doi: 10.1038/2151084a0. [DOI] [PubMed] [Google Scholar]
  12. Pinckard R. N., Weir D. M., McBride W. H. Factors influencing the immune response. I. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intravenous injection of bovine serum albumin in rabbits. Clin Exp Immunol. 1967 May;2(3):331–341. [PMC free article] [PubMed] [Google Scholar]
  13. Pinckard R. N., Weir D. M., McBride W. H. Factors influencing the immune response. II. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intraperitoneal injection of bovine serum albumin in rabbits. Clin Exp Immunol. 1967 May;2(3):343–350. [PMC free article] [PubMed] [Google Scholar]
  14. Woodruff M. F., Boak J. L. Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer. 1966 Jun;20(2):345–355. doi: 10.1038/bjc.1966.42. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES