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. 1968 Nov;3(9):983–988.

Chronic pulmonary disease associated with an unusual dysgammaglobulinaemia

J I Tennenbaum, R L St Pierre, G J Cerilli
PMCID: PMC1579015  PMID: 4179958

Abstract

A 26-year-old patient, subject to recurrent sino-pulmonary infections, with a previously unreported combination of immunological deficiencies is reported. There was a lack of serum immunoglobulin A, salivary immunoglobulin A, decreased serum immunoglobulin M and a deficiency of cellular immunity. It is suggested that this combination of deficits may represent a forme fruste of hereditary ataxia telangiectasia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BACH F. H., HIRSCHHORN K. THE IN VITRO IMMUNE RESPONSE OF PERIPHERAL BLOOD LYMPHOCYTES. Semin Hematol. 1965 Jan;2:68–89. [PubMed] [Google Scholar]
  2. BARANDUN S., STAMPFLI K., SPENGLER G. A., RIVA G. Die Klinik des Antikörpermangelsyndroms. Helv Med Acta. 1959 May;26(2):163–contd. [PubMed] [Google Scholar]
  3. BRUTON O. C. Agammaglobulinemia. Pediatrics. 1952 Jun;9(6):722–728. [PubMed] [Google Scholar]
  4. Bachmann R. Studies on the serum gamma-A-globulin level. 3. The frequency of A-gamma-A-globulinemia. Scand J Clin Lab Invest. 1965;17(4):316–320. doi: 10.3109/00365516509077057. [DOI] [PubMed] [Google Scholar]
  5. Bellanti J. A. Role of local gamma-A-immunoglobulins in immunity. Am J Dis Child. 1968 Feb;115(2):239–246. doi: 10.1001/archpedi.1968.02100010241013. [DOI] [PubMed] [Google Scholar]
  6. Crabbé P. A., Heremans J. F. Selective IgA deficiency with steatorrhea. A new syndrome. Am J Med. 1967 Feb;42(2):319–326. doi: 10.1016/0002-9343(67)90031-9. [DOI] [PubMed] [Google Scholar]
  7. GILBERT C., HONG R. QUALITATIVE AND QUANTITATIVE IMMUNOGLOBULIN DEFICIENCY. Am J Med. 1964 Oct;37:602–609. doi: 10.1016/0002-9343(64)90072-5. [DOI] [PubMed] [Google Scholar]
  8. Gill F. A. The association of increased spontaneous lymphocyte transformation in vitro with clinical manifestations of drug hypersensitivity. J Immunol. 1967 Apr;98(4):778–785. [PubMed] [Google Scholar]
  9. Huntley C. C., Thorpe D. P., Lyerly A. D., Kelsey W. M. Rheumatoid arthritis with IgA deficiency. Am J Dis Child. 1967 Apr;113(4):411–418. doi: 10.1001/archpedi.1967.02090190057002. [DOI] [PubMed] [Google Scholar]
  10. Kirkpatrick C. H., Schimke R. N. Paternal immunoglobulin abnormalities in congenital hypogammaglobulinemia. JAMA. 1967 Apr 10;200(2):105–110. [PubMed] [Google Scholar]
  11. Krieger I., Brough J. A. Gamma-A deficiency and hypochromic anemia due to defective iron mobilization. N Engl J Med. 1967 Apr 20;276(16):886–894. doi: 10.1056/NEJM196704202761602. [DOI] [PubMed] [Google Scholar]
  12. Rosen F. S., Janeway C. A. The gamma globulins. 3. The antibody deficiency syndromes. N Engl J Med. 1966 Oct 6;275(14):769–concl. doi: 10.1056/NEJM196610062751407. [DOI] [PubMed] [Google Scholar]
  13. Shannon D. C., Johnson G., Rosen F. S., Austen K. F. Cellular reactivity to Candida albicans antigen. N Engl J Med. 1966 Sep 29;275(13):690–693. doi: 10.1056/NEJM196609292751302. [DOI] [PubMed] [Google Scholar]
  14. South M. A., Copper M. D., Wollheim F. A., Good R. A. The IgA system. II. The clinical significance of IgA deficiency: studies in patients with agammaglobulinemia and ataxia-telangiectasia. Am J Med. 1968 Feb;44(2):168–178. doi: 10.1016/0002-9343(68)90148-4. [DOI] [PubMed] [Google Scholar]
  15. TOMASI T. B., Jr, TAN E. M., SOLOMON A., PRENDERGAST R. A. CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS. J Exp Med. 1965 Jan 1;121:101–124. doi: 10.1084/jem.121.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. TURNER M. W., ROWE D. S. CHARACTERIZATION OF HUMAN ANTIBODIES TO SALMONELLA TYPHI BY GEL-FILTRATION AND ANTIGENIC ANALYSIS. Immunology. 1964 Nov;7:639–656. [PMC free article] [PubMed] [Google Scholar]
  17. Tokumaru T. A possible role of gamma-A-immunoglobulin in herpes simplex virus infection in man. J Immunol. 1966 Aug;97(2):248–259. [PubMed] [Google Scholar]
  18. YOUNG R. R., AUSTEN K. F., MOSER H. W. ABNORMALITIES OF SERUM GAMMA-1-A GLOBULIN AND ATAXIA TELANGIECTASIA. Medicine (Baltimore) 1964 May;43:423–433. doi: 10.1097/00005792-196405000-00021. [DOI] [PubMed] [Google Scholar]

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