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. 1969 Jun;4(6):685–690.

Ig-allotype–anti-Ig-allotype reaction in rabbit skin

H Fritz, Bo Husberg
PMCID: PMC1579034  PMID: 4389054

Abstract

In rabbits immunized against allotype specificities local dermal reactions were produced by intradermal injections of the appropriate allotype antigen. The reactions were characterized by redness of the skin, infiltration and oedema. The reactions initially appeared about 24 hr after the intradermal injections. In fully immunized rabbits they appeared about 4 hr after the injections. The reactions appearing after 4 hr were histologically characterized by perivascular polymorphonuclear leucocyte infiltration, extravasation of blood corpuscles and endothelial swelling. The dermal reactivity could be prevented by pretreatment of the animal with cyclophosphamide. Antihistamine treatment did not suppress the reactivity. The reaction appeared to be of Arthus type.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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