Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1969 Sep;5(3):311–316.

Histamine release from human lung by specific antisera

W Paul, D M Weir
PMCID: PMC1579115  PMID: 4185722

Abstract

Several specific antisera have been tested for ability to release histamine from samples of washed, normal human lung in vitro. Goat anti-rat serum, sheep anti-rabbit serum, goat anti-human IgA and goat anti-human IgM were inactive at the dilutions tested. Goat anti-human IgG and Coomb's reagent appeared to have some histamine releasing activity. Sheep anti-human IgE was the most active of the antisera tested. The significance of these results is discussed.

Full text

PDF
311

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allansmith M., Buell D. Immunoglobulins in the skin of allergic and nonallergic individuals. J Immunol. 1965 Nov;95(5):951–958. [PubMed] [Google Scholar]
  2. Assem E. S., Schild H. O. Detection of allergy to penicillin and other antigens by in-vitro passive sensitization and histamine release from human and monkey lung. Br Med J. 1968 Aug 3;3(5613):272–276. doi: 10.1136/bmj.3.5613.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Becker E. L., Austen K. F. Mechanisms of immunologic injury of rat peritoneal mast cells. I. The effect of phosphonate inhibitors on the homocytotropic antibody-mediated histamine release and the first component of rat complement. J Exp Med. 1966 Sep 1;124(3):379–395. doi: 10.1084/jem.124.3.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloch K. J. The anaphylactic antibodies of mammals including man. Prog Allergy. 1967;10:84–150. [PubMed] [Google Scholar]
  5. Henney C. S., Ishizaka K. Antigenic determinants specific for aggregated gamma G-globulins. J Immunol. 1968 Apr;100(4):718–725. [PubMed] [Google Scholar]
  6. Immunoglobulin E. A new class of human immunoglobulin. J Immunol. 1968 May;100(5):1143–1143. [PubMed] [Google Scholar]
  7. Ishizaka K., Ishizaka T., Hornbrook M. M. Allergen-binding activity of gamma-E, gamma-G and gamma-A antibodies in sera from atopic patients. In vitro measurements of reaginic antibody. J Immunol. 1967 Mar;98(3):490–501. [PubMed] [Google Scholar]
  8. Ishizaka K., Ishizaka T., Hornbrook M. M. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol. 1966 Jul;97(1):75–85. [PubMed] [Google Scholar]
  9. Ishizaka K., Ishizaka T., Hornbrook M. M. Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth gamma-E-globulin antibody. J Immunol. 1966 Dec;97(6):840–853. [PubMed] [Google Scholar]
  10. Ishizaka K., Ishizaka T. Identification of gamma-E-antibodies as a carrier of reaginic activity. J Immunol. 1967 Dec;99(6):1187–1198. [PubMed] [Google Scholar]
  11. Ishizaka K., Ishizaka T. Induction of erythema-wheal reactions by soluble antigen-gammaE antibody complexes in humans. J Immunol. 1968 Jul;101(1):68–78. [PubMed] [Google Scholar]
  12. Ishizaka K., Ishizaka T. Reversed type allergic skin reactions by anti-gamma-E-globulin antibodies in humans and monkeys. J Immunol. 1968 Mar;100(3):554–562. [PubMed] [Google Scholar]
  13. Ishizaka K., Ishizaka T., Terry W. D. Antigenic structure of gamma-E-globulin and reaginic antibody. J Immunol. 1967 Nov;99(5):849–858. [PubMed] [Google Scholar]
  14. Johansson S. G., Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology. 1967 Oct;13(4):381–394. [PMC free article] [PubMed] [Google Scholar]
  15. MCILWAIN H., BUDDLE H. L. Techniques in tissue metabolism. I. A mechanical chopper. Biochem J. 1953 Feb;53(3):412–420. doi: 10.1042/bj0530412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MONGAR J. L., SCHILD H. O. Quantitative measurement of the histamine-releasing activity of a series of mono-alkyl-amines using minced guinea-pig lung. Br J Pharmacol Chemother. 1953 Mar;8(1):103–109. doi: 10.1111/j.1476-5381.1953.tb00760.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Morse H. C., 3rd, Austen K. F., Bloch K. J. Biologic properties of rat antibodies. 3. Histamine release mediated by two classes of antibodies. J Immunol. 1969 Feb;102(2):327–337. [PubMed] [Google Scholar]
  18. Parish W. E. Release of histamine and slow reacting substance with mast cell changes after challenge of human lung sensitized passively with reagin in vitro. Nature. 1967 Aug 12;215(5102):738–739. doi: 10.1038/215738a0. [DOI] [PubMed] [Google Scholar]
  19. Sheard P., Killingback P. G., Blair A. M. Antigen induced release of histamine and SRS-A from human lung passively sensitized with reaginic serum. Nature. 1967 Oct 21;216(5112):283–284. doi: 10.1038/216283a0. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES