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. 1969 Dec;5(6):567–595.

Adoptive transfer of the diseases of New Zealand Black mice to normal mouse strains

A M Denman, A S Russell, Evelyn J Denman
PMCID: PMC1579151  PMID: 4904067

Abstract

Lymphoid cells from New Zealand Black (NZB) and (C57BL × NZB)F1 mice with Coombs positive haemolytic anaemia and the other disease features of these strains, and also cells from young NZB mice without established disease, were transferred to BALB/c and C57BL recipients treated with anti-lymphocyte globulin. Donor strain skin grafts and anti-allotype antibody to (C57BL × NZB)F1 IgG were used to assess the fate of the transferred lymphoid cells. Haematological, serological, biochemical and histological criteria were used to indicate successful transfer of NZB disease to the normal recipients. Spleen cells from old NZB mice which survived in BALB/c recipients transferred the full disease picture of the donor. A less complete, but nevertheless wide, spectrum of abnormalitie was induced in other recipient groups. NZB lymphoid cells exposed to anti-lymphocyte globulin in vitro before transfer and cell-free filtrates were virtually innocuous. The findings make it unlikely that graft-versus-host disease or anti-lymphocyte globulin itself could account for the abnormalities in the recipients. It seems probable that two factors determined the disease picture in the recipients, namely virus infection, differing widely in its extent and distribution, and the nature of the host response which in turn was determined by the duration of NZB lymphoid cell survival following transfer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Berman L. D., Levey R. H. Increased tumour induction by adenovirus type 12 in thymectomized mice and mice treated with anti-lymphocyte serum. Nature. 1967 Jul 8;215(5097):185–187. doi: 10.1038/215185a0. [DOI] [PubMed] [Google Scholar]
  2. BILLINGHAM R. E., DEFENDIV, SILVERS W. K., STEINMULLER D. Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats. J Natl Cancer Inst. 1962 Feb;28:365–435. [PubMed] [Google Scholar]
  3. Bainbridge D. R., Brent L., Gowland G. Distribution of allogeneic 51Cr-labelled lymph node cells in mice. Transplantation. 1966 Mar;4(2):138–153. doi: 10.1097/00007890-196603000-00003. [DOI] [PubMed] [Google Scholar]
  4. Canecer in children. Lancet. 1968 Jul 6;2(7558):32–33. [PubMed] [Google Scholar]
  5. DUNN T. B. Normal and pathologic anatomy of the reticular tissue in laboratory mice, with a classification and discussion of neoplasms. J Natl Cancer Inst. 1954 Jun;14(6):1281–1433. [PubMed] [Google Scholar]
  6. Denman A. M., Denman E. J., Embling P. H. Changes in the life-span of circulating small lymphocytes in mice after treatment with anti-lymphocyte globulin. Lancet. 1968 Feb 17;1(7538):321–325. doi: 10.1016/s0140-6736(68)90791-5. [DOI] [PubMed] [Google Scholar]
  7. Denman A. M., Denman E. J., Holborow E. J. Suppression of Coombs-positive haemolytic anaemia in NZB mice by antilymphocyte globulin. Lancet. 1967 May 20;1(7499):1084–1086. doi: 10.1016/s0140-6736(67)92653-0. [DOI] [PubMed] [Google Scholar]
  8. Denman A. M., Frenkel E. P. Mode of action of anti-lymphocyte globulin. I. The distribution of rabbit anti-lymphocyte globulin injected into rats and mice. Immunology. 1968 Jan;14(1):107–113. [PMC free article] [PubMed] [Google Scholar]
  9. Denman A. M., Frenkel E. P. Studies of the effect of induced immune lymphopenia. I. Enhanced effects of rabbit anti-rat lymphocyte globulin in rats tolerant to rabbit immunoglobulin G. J Immunol. 1967 Sep;99(3):498–507. [PubMed] [Google Scholar]
  10. East J., De Sousa M. A., Prosser P. R., Jaquet H. Malignant changes in New Zealand black mice. Clin Exp Immunol. 1967 Jul;2(4):427–443. [PMC free article] [PubMed] [Google Scholar]
  11. East J., Prosser P. R. Autoimmunity and malignancy in New Zealand black mice. Proc R Soc Med. 1967 Aug;60(8):823–825. [PMC free article] [PubMed] [Google Scholar]
  12. East J., de Sousa M. A., Parrott D. M. Immunopathology of New Zealand black (NZB) mice. Transplantation. 1965 Nov;3(6):711–729. doi: 10.1097/00007890-196511000-00003. [DOI] [PubMed] [Google Scholar]
  13. FAHEY J. L., WUNDERLICH J., MISHELL R. THE IMMUNOGLOBULINS OF MICE. I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S GAMMA-2-, 7S GAMMA-1-, GAMMA-1A (BETA-2A)-, AND 18S GAMMA-1M-GLOBULINS. J Exp Med. 1964 Aug 1;120:223–242. doi: 10.1084/jem.120.2.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Gengozian N., Congdon C. C. Effect of syngeneic antilymphocyte serum on rat-mouse radiation chimeras. A preliminary report. Transplant Proc. 1969 Mar;1(1):34–38. [PubMed] [Google Scholar]
  15. HELYER B. J., HOWIE J. B. THE THYMUS AND AUTOIMMUNE DISEASE. Lancet. 1963 Nov 16;2(7316):1026–1029. doi: 10.1016/s0140-6736(63)90003-5. [DOI] [PubMed] [Google Scholar]
  16. HOLMES M. C., BURNET F. M. THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS. Ann Intern Med. 1963 Sep;59:265–276. doi: 10.7326/0003-4819-59-3-265. [DOI] [PubMed] [Google Scholar]
  17. HOLMES M. C., GORIE J., BURNET F. M. Transmission by splenic cells of an autoimmune disease occurring spontaneously in mice. Lancet. 1961 Sep 16;2(7203):638–639. doi: 10.1016/s0140-6736(61)90313-0. [DOI] [PubMed] [Google Scholar]
  18. Hicks J. D. Vascular changes in the kidneys of NZB mice and F1 NZBxNZW hybrids. J Pathol Bacteriol. 1966 Apr;91(2):479–486. doi: 10.1002/path.1700910222. [DOI] [PubMed] [Google Scholar]
  19. Hirsch M. S., Murphy F. A., Hicklin M. D. Immunopathology of lymphocytic choriomeningitis viurs infection of newborn mice. Antithymocyte serum effects on glomerulonephritis and wasting disease. J Exp Med. 1968 Apr 1;127(4):757–766. doi: 10.1084/jem.127.4.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hollmann K. H., Verley J. M. Présence de particules virales dans les organes de la souris NZB. C R Acad Sci Hebd Seances Acad Sci D. 1967 Feb 6;264(6):871–873. [PubMed] [Google Scholar]
  21. James K. Anti-lymphocytic antibody--a review. Clin Exp Immunol. 1967 Nov;2(6):615–631. [PMC free article] [PubMed] [Google Scholar]
  22. Jeejeebhoy H. F. Immunological studies on the rat thymectomized in adult life. Immunology. 1965 Nov;9(5):417–425. [PMC free article] [PubMed] [Google Scholar]
  23. Klein J., Martínková J., Herzenberg L. A. Analysis of the histocompatibility-2 (H-2) locus of NZB mice. Transplantation. 1967 Sep 5;5(5):1335–1338. doi: 10.1097/00007890-196709000-00012. [DOI] [PubMed] [Google Scholar]
  24. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Leuchars E., Wallis V. J., Davies A. J. Mode of action for anti-lymphocyte serum. Nature. 1968 Sep 28;219(5161):1325–1328. doi: 10.1038/2191325a0. [DOI] [PubMed] [Google Scholar]
  26. Levey R. H., Medawar P. B. Further experiments on the action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1967 Aug;58(2):470–477. doi: 10.1073/pnas.58.2.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Lewis R. M., Armstrong M. Y., André-Schwartz J., Muftuoglu A., Beldotti L., Schwartz R. S. Chronic allogeneic disease. I. Development of glomerulonephritis. J Exp Med. 1968 Oct 1;128(4):653–679. doi: 10.1084/jem.128.4.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Lindsey E. S., Donaldson G. W., Woodruff M. F. Erythrocyte survival in normal mice and in mice with autoimmune haemolytic anaemia. Clin Exp Immunol. 1966 Jan;1(1):85–98. [PMC free article] [PubMed] [Google Scholar]
  29. MARDINEY M. R., Jr, MUELLER-EBERHARD H. J. MOUSE BETA-1C-GLOBULIN: PRODUCTION OF ANTISERUM AND CHARACTERIZATION IN THE COMPLEMENT REACTION. J Immunol. 1965 Jun;94:877–882. [PubMed] [Google Scholar]
  30. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  31. Martin W. J., Miller J. F. Site of action of antilymphocyte globulin. Lancet. 1967 Dec 16;2(7529):1285–1287. doi: 10.1016/s0140-6736(67)90395-9. [DOI] [PubMed] [Google Scholar]
  32. Masters J. M., Spurling C. L. Induction of autoimmune hemolytic disease by diffusible substances from the thymus of NZB/B1 mice. Blood. 1967 Nov;30(5):569–575. [PubMed] [Google Scholar]
  33. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy. J Exp Med. 1966 Dec 1;124(6):1031–1038. doi: 10.1084/jem.124.6.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice. J Exp Med. 1967 Jul 1;126(1):53–62. doi: 10.1084/jem.126.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. OLINER H., SCHWARTZ R., DAMESHEK W. Studies in experimental autoimmune disorders. I. Clinical and laboratory features of autoimmunization (runt disease) in the mouse. Blood. 1961 Jan;17:20–44. [PubMed] [Google Scholar]
  36. Oldstone M. B., Dixon F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med. 1969 Mar 1;129(3):483–505. doi: 10.1084/jem.129.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Playfair J. H. Strain differences in the immune response of mice. II. Responses by neonatal cells in irradiated adult hosts. Immunology. 1968 Dec;15(6):815–826. [PMC free article] [PubMed] [Google Scholar]
  38. Prosser P. R. Particles resembling murine leukaemia virus in New Zealand black mice. Clin Exp Immunol. 1968 Mar;3(3):213–226. [PMC free article] [PubMed] [Google Scholar]
  39. Russell A. S., Denman A. M. Normal induction and maintenance of tolerance in (NZBxNZW) F1 mice. Clin Exp Immunol. 1969 Sep;5(3):265–272. [PMC free article] [PubMed] [Google Scholar]
  40. Seller M. J., Polani P. E. Transplantation of allogeneic haemopoietic tissue in adult anaemic mice of the W series using antilymphocytic serum. Lancet. 1969 Jan 4;1(7584):18–21. doi: 10.1016/s0140-6736(69)90985-4. [DOI] [PubMed] [Google Scholar]
  41. Silvers W. K., Billingham R. E. Studies on the immunotherapy of runt disease in rats. J Exp Med. 1969 Apr 1;129(4):647–661. doi: 10.1084/jem.129.4.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Snell G. D. The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol (Praha) 1968;14(5):335–358. [PubMed] [Google Scholar]
  43. Stutman O., Yunis E. J., Good R. A. Deficient immunologic functions of NZB mice. Proc Soc Exp Biol Med. 1968 Apr;127(4):1204–1207. doi: 10.3181/00379727-127-32910. [DOI] [PubMed] [Google Scholar]
  44. TOMBS M. P., SOUTER F., MACLAGAN N. F. The spectrophotometric determination of protein at 210 millimicrons. Biochem J. 1959 Sep;73:167–171. doi: 10.1042/bj0730167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Turk J. L., Willoughby D. A. Central and peripheral effects of anti-lymphocyte sera. Lancet. 1967 Feb 4;1(7484):249–251. doi: 10.1016/s0140-6736(67)91307-4. [DOI] [PubMed] [Google Scholar]
  46. Vandeputte M. Antilymphocytic serum and polyoma oncogenesis in rats. Transplant Proc. 1969 Mar;1(1):100–105. [PubMed] [Google Scholar]
  47. Warner N. L., Wistar R., Jr Immunoglobulins in NZB-BL mice. I. Serum immunoglobulin levels and immunoglobulin class of erythrocyte autoantibody. J Exp Med. 1968 Jan 1;127(1):169–183. doi: 10.1084/jem.127.1.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Yumoto T., Dmochowski L. Light and electron microscope studies of organs and tissues of the New Zealand Black (NZB/BL) strain mice with lymphoid leukemia and autoimmune disease. Cancer Res. 1967 Nov;27(11):2083–2097. [PubMed] [Google Scholar]

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