Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1966 Apr;1(2):119–128.

The incidence of parathyroid and other antibodies in the sera of patients with idiopathic hypoparathyroidism

R M Blizzard, D Chee, W Davis
PMCID: PMC1579183  PMID: 5330781

Abstract

Parathyroid antibodies were demonstrated in 38% of seventy-four patients with idiopathic hypoparathyroidism, 26% of ninety-two patients with idiopathic Addison's disease, 12% of forty-nine patients with Hashimoto's thyroiditis, and in 6% of 245 control patients. A significant percentage of patients with idiopathic hypoparathyroidism also had adrenal, thyroid and/or gastric parietal cell antibodies, even in the absence of diagnosed Addison's disease, thyroid disease, or pernicious anaemia. The antibody(s) against parathyroid tissue are not against parathyroid hormone, and do not cross-react in absorption studies with gastric, thyroid, adrenal, liver or kidney tissue. Species specificity was not investigated. The diagnostic and theoretic considerations are presented.

Full text

PDF
119

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON J. R., GOUDIE R. B., GRAY K. G., TIMBURY G. C. Auto-antibodies in Addison's disease. Lancet. 1957 Jun 1;272(6979):1123–1124. doi: 10.1016/s0140-6736(57)91687-2. [DOI] [PubMed] [Google Scholar]
  2. BAUR S., ROITT I. M., DONIACH D. CHARACTERIZATION OF THE HUMAN GASTRIC PARIETAL CELL AUTO-ANTIGEN. Immunology. 1965 Jan;8:62–68. [PMC free article] [PubMed] [Google Scholar]
  3. BLIZZARD R. M., CHANDLER R. W., KYLE M. A., HUNG W. Adrenal antibodies in Addison's disease. Lancet. 1962 Nov 3;2(7262):901–903. doi: 10.1016/s0140-6736(62)90681-5. [DOI] [PubMed] [Google Scholar]
  4. BLIZZARD R. M., KYLE M. STUDIES OF THE ADRENAL ANTIGENS AND ANTIBODIES IN ADDISON'S DISEASE. J Clin Invest. 1963 Oct;42:1653–1660. doi: 10.1172/JCI104851. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DAVIS R. H., FOURMAN P., SMITH J. W. Prevalence of parathyroid insufficiency after thyroidectomy. Lancet. 1961 Dec 30;2(7218):1432–1435. doi: 10.1016/s0140-6736(61)91249-1. [DOI] [PubMed] [Google Scholar]
  6. DONIACH D., ROITT I. M. AN EVALUATION OF GASTRIC AND THYROID AUTO-IMMUNITY IN RELATION TO HEMATOLOGIC DISORDERS. Semin Hematol. 1964 Jul;1:313–343. [PubMed] [Google Scholar]
  7. GOLDSTEIN G., SLIZYS I. S., CHASE M. W. Studies on fluorescent antibody staining. I. Non-specific fluorescence with fluorescein-coupled sheep anti-rabbit globulins. J Exp Med. 1961 Jul 1;114:89–110. doi: 10.1084/jem.114.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOLBOROW E. J., BROWN P. C., ROITT I. M., DONIACH D. Cytoplasmic localization of "complement-fixing" auto-antigen in human thyroid epithelium. Br J Exp Pathol. 1959 Dec;40:583–588. [PMC free article] [PubMed] [Google Scholar]
  9. HUNG W., MIGEON C. J., PARROTT R. H. A POSSIBLE AUTOIMMUNE BASIS FOR ADDISON'S DISEASE IN THREE SIBLINGS, ONE WITH IDIOPATHIC HYPOPARATHYROIDISM, PERNICIOUS ANEMIA AND SUPERFICIAL MONILIASIS. N Engl J Med. 1963 Sep 26;269:658–663. doi: 10.1056/NEJM196309262691303. [DOI] [PubMed] [Google Scholar]
  10. IRVINE W. J. GASTRIC ANTIBODIES STUDIED BY FLUORESCENCE MICROSCOPY. Q J Exp Physiol Cogn Med Sci. 1963 Oct;48:427–438. doi: 10.1113/expphysiol.1963.sp001685. [DOI] [PubMed] [Google Scholar]
  11. IRVINE W. J. IMMUNOLOGIC ASPECTS OF PERNICIOUS ANEMIA. N Engl J Med. 1965 Aug 19;273:432–438. doi: 10.1056/NEJM196508192730807. [DOI] [PubMed] [Google Scholar]
  12. JANKOVIC B. D., ISVANESKI M., POPESKOVIC L., MITROCIC K. EXPERIMENTAL ALLERGIC THYROIDITIS (AND PARATHYROIDITIS) IN NEONATALLY THYMECTOMIZED AND BURSECTOMIZED CHICKENS. PARTICIPATION OF THE THYMUS IN THE DEVELOPMENT OF DISEASE. Int Arch Allergy Appl Immunol. 1965;26:18–33. [PubMed] [Google Scholar]
  13. KENNY F. M., HOLLIDAY M. A. HYPOPARATHYROIDISM, MONILIASIS, ADDISON'S AND HASHIMOTO'S DISEASES. HYPERCALCEMIA TREATED WITH INTRAVENOUSLY ADMINISTERED SODIUM SULFATE. N Engl J Med. 1964 Oct 1;271:708–713. doi: 10.1056/NEJM196410012711404. [DOI] [PubMed] [Google Scholar]
  14. LUPULESCU A., SIMIONESCU L., MERCULIEV E., POP A., BONA C. DIE ROLLE DER OSTROGENHORMONE BEI DER ENTWICKLUNG DES IMMUNOLOGISCHEN KANINCHENKROPFES. Endokrinologie. 1963 Aug;44:335–346. [PubMed] [Google Scholar]
  15. Lupulescu A., Pop A., Merculiev E., Neacsu C., Heitmanek C. Experimental iso-immune hypoparathyroidism in rats. Nature. 1965 Apr 24;206(982):415–416. doi: 10.1038/206415a0. [DOI] [PubMed] [Google Scholar]
  16. MORSE W. I., COCHRANE W. A., LANDRIGAN P. L. Familial hypoparathyroidism with pernicious anemia, steatorrhea and adrenocortical insufficiency: a variant of mucoviscidosis. N Engl J Med. 1961 May 18;264:1021–1026. doi: 10.1056/NEJM196105182642003. [DOI] [PubMed] [Google Scholar]
  17. RIGGS J. L., LOH P. C., EVELAND W. C. A simple fractionation method for preparation of fluorescein-labeled gamma globulin. Proc Soc Exp Biol Med. 1960 Dec;105:655–658. doi: 10.3181/00379727-105-26207. [DOI] [PubMed] [Google Scholar]
  18. SOBER H. A., PETERSON E. A. Protein chromatography on ion exchange cellulose. Fed Proc. 1958 Dec;17(4):1116–1126. [PubMed] [Google Scholar]
  19. SOLOMON I. L., BLIZZARD R. M. AUTOIMMUNE DISORDERS OF ENDOCRINE GLANDS. J Pediatr. 1963 Nov;63:1021–1033. doi: 10.1016/s0022-3476(63)80235-8. [DOI] [PubMed] [Google Scholar]
  20. TAYLOR K. B., ROITT I. M., DONIACH D., COUCHMAN K. G., SHAPLAND C. Autoimmune phenomena in pernicious anaemia: gastric antibodies. Br Med J. 1962 Nov 24;2(5316):1347–1352. doi: 10.1136/bmj.2.5316.1347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. TROTTER W. R., BELYAVIN G., WADDAMS A. Precipitating and complement-fixing antibodies in Hashimoto's disease. Proc R Soc Med. 1957 Nov;50(11):961–962. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES