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. 1966 Jul;1(3):307–321.

A cytotoxic antibody for cultured nervous tissue in serum and cerebrospinal fluid from rhesus monkeys with allergic encephalomyelitis

G Lamoureux, G Boulay, A G Borduas
PMCID: PMC1579201  PMID: 4957954

Abstract

1. A factor, probably a γ-globulin, which was toxic for myelin and glial cells in culture appeared in the cerebrospinal fluid (CSF) and serum of rhesus monkeys with experimental allergic encephalomyelitis. This factor first appeared in serum and CSF 7 days after the animals had been injected with nervous tissue in Freund's complete adjuvant and increased in titre thereafter.

2. After immunization there was a rise of γ-globulin concentration in both serum and CSF, this rise coinciding with the appearance and increase of cytotoxic activity for nerve cell preparations. Immunoelectrophoresis of CSF showed an increased density of the immunoglobulin G (IgG) line after immunization. The cytotoxicity of serum and CSF proved to be more sensitive and reliable than the fluorescence technique and the antiglobulin consumption test for assessing the development of the disease.

3. After a rapid increase the cytotoxic factor maintained a steady value during a period variable for each animal suggesting the presence of a `defence reaction' against the aggressive antibody. Whether or not this `defence reaction' was mediated by protective antibody remains to be established.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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