Skip to main content
PMC home page
Public Health Reports logoLink to Public Health Reports
. 1989 Mar-Apr;104(2):151–155.

Isoniazid hepatitis among pregnant and postpartum Hispanic patients.

A L Franks 1, N J Binkin 1, D E Snider Jr 1, W M Rokaw 1, S Becker 1
PMCID: PMC1580026  PMID: 2495549

Abstract

On request of local health officials, the authors investigated isoniazid (INH) hepatitis morbidity and mortality among patients attending an Hispanic prenatal clinic. Among 3,681 women treated with INH during and after pregnancy to prevent tuberculosis (TB), 5 developed INH hepatitis, and 2 of the 5 women died. Comparison with previously collected Public Health Service data concerning 3,948 nonpregnant women, using the Cox proportional hazards model, revealed a 2.5-fold increased risk of INH hepatitis in the prenatal clinic group. The mortality rate was four times higher in the prenatal clinic group. However, statistical power was low because of the small number of cases, and neither of these findings was statistically significant (P greater than 0.05). In the absence of controlled studies, the issue of INH safety during the perinatal period remains unresolved. Nevertheless, current American Thoracic Society-Centers for Disease Control recommendations regarding TB screening, implementation of INH chemoprophylaxis programs, and adequate monitoring of individuals on INH should be adhered to. The results of this investigation raise concern that deviations from existing policy may contribute to unnecessary morbidity and mortality.

Full text

PDF
151

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COMBES B., SHIBATA H., ADAMS R., MITCHELL B. D., TRAMMELL V. ALTERATIONS IN SULFOBROMOPHTHALEIN SODIUM-REMOVAL MECHANISMS FROM BLOOD DURING NORMAL PREGNANCY. J Clin Invest. 1963 Sep;42:1431–1442. doi: 10.1172/JCI104828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Khuroo M. S., Teli M. R., Skidmore S., Sofi M. A., Khuroo M. I. Incidence and severity of viral hepatitis in pregnancy. Am J Med. 1981 Feb;70(2):252–255. doi: 10.1016/0002-9343(81)90758-0. [DOI] [PubMed] [Google Scholar]
  3. Kopanoff D. E., Snider D. E., Jr, Caras G. J. Isoniazid-related hepatitis: a U.S. Public Health Service cooperative surveillance study. Am Rev Respir Dis. 1978 Jun;117(6):991–1001. doi: 10.1164/arrd.1978.117.6.991. [DOI] [PubMed] [Google Scholar]
  4. Leff A., Herskowitz D., Gibert J., Brewin A. Tuberculosis chemoprophylaxis practices in metropolitan clinics. Am Rev Respir Dis. 1979 Jan;119(1):161–170. doi: 10.1164/arrd.1979.119.1.161. [DOI] [PubMed] [Google Scholar]
  5. Leff D. R., Leff A. R. Tuberculosis control practices in major metropolitan health departments in the United States. 3. Standard of practice in 1984. Chest. 1985 Feb;87(2):206–211. [PubMed] [Google Scholar]
  6. McCormack W. M., George H., Donner A., Kodgis L. F., Alpert S., Lowe E. W., Kass E. H. Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother. 1977 Nov;12(5):630–635. doi: 10.1128/aac.12.5.630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. NAIDU S. S., VISWANATHAN R. Infectious hepatitis in pregnancy during Delhi epidemic. Indian J Med Res. 1957 Jan;45(Suppl):71–76. [PubMed] [Google Scholar]
  8. Snider D. E., Jr, Layde P. M., Johnson M. W., Lyle M. A. Treatment of tuberculosis during pregnancy. Am Rev Respir Dis. 1980 Jul;122(1):65–79. doi: 10.1164/arrd.1980.122.1.65. [DOI] [PubMed] [Google Scholar]
  9. WHALLEY P. J., ADAMS R. H., COMBES B. TETRACYCLINE TOXICITY IN PREGNANCY. LIVER AND PANCREATIC DYSFUNCTION. JAMA. 1964 Aug 3;189:357–362. [PubMed] [Google Scholar]

Articles from Public Health Reports are provided here courtesy of SAGE Publications

RESOURCES