Abstract
The results of critical tests on thiabendazole given at three dose levels, 50 mg/kg, 80 mg/kg and 100 mg/kg, to groups of naturally parasitized lambs are reported. While the compound appeared to be efficient at all levels, the best results were obtained at 100 mg/kg. The total percentage removals of all worms present in the gut at these three dosage levels were 79.1 per cent at the 50 mg/kg level, 96.3 per cent at the 80 mg/kg level and 99.5 per cent at the 100 mg/kg level.
No activity against T. ovis, Capillaria or Moniezia was observed. Useful activity in a limited number of lambs was observed against Dictyocaulus filaria especially at the 100 mg/kg level.
This drug appeared to be completely effective at the 100 mg/kg level in removing tissue-phase parasites.
Inhibitory activity against developing larvae in faecal cultures obtained 24 hours after dosing was also shown.
At levels up to 500 mg/kg the drug appeared relatively non-toxic. The result at 800 mg/kg was complicated by the death of the treated animal 22 days after dosing from a septicaemia. Dosage at a level of 1.6 mg/kg proved rapidly fatal to a ewe. No effect on pregnant ewes or the lambs therefrom was observed at a dose level of 160 mg/kg.
The most efficient level for routine treatment of sheep under Canadian conditions of management would appear to be 100 mg/kg of body weight. This compound appears to be the best anthelmintic to have been tried to date at this laboratory against the internal parasites of sheep.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- GORDON H. M. Thiabendazole: a highly effective anthelmintic for sheep. Nature. 1961 Sep 30;191:1409–1410. doi: 10.1038/1911409a0. [DOI] [PubMed] [Google Scholar]
- Gibbs H. C., Pullin J. W. Observations on the Anthelmintic Efficiency of 4 Tert Butyl 2 Chlorophenyl Methyl Methylphosphoramidate (Ruelene) on the Internal Parasites of Sheep. Can J Comp Med Vet Sci. 1961 Jul;25(7):171–177. [PMC free article] [PubMed] [Google Scholar]
- Gibbs H. C., Pullin J. W. Tests on Methyridine as an Anthelmintic in Sheep. Can J Comp Med Vet Sci. 1962 Jul;26(7):163–166. [PMC free article] [PubMed] [Google Scholar]