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. 1973 Aug 11;3(5875):326–328. doi: 10.1136/bmj.3.5875.326

Glomerular Deposition of Properdin in Henoch-Schönlein Syndrome and Idiopathic Focal Nephritis

D J Evans, D Gwyn Williams, D K Peters, J G P Sissons, J M Boulton-Jones, C S Ogg, J S Cameron, B I Hoffbrand
PMCID: PMC1586453  PMID: 4579400

Abstract

Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AYOUB E. M., VERNIER R. L. BENIGN RECURRENT HEMATURIA. Am J Dis Child. 1965 Mar;109:217–223. doi: 10.1001/archpedi.1965.02090020219004. [DOI] [PubMed] [Google Scholar]
  2. Berger J. IgA glomerular deposits in renal disease. Transplant Proc. 1969 Dec;1(4):939–944. [PubMed] [Google Scholar]
  3. HEPTINSTALL R. H., JOEKES A. M. Focal glomerulonephritis. A study based on renal biopsies. Q J Med. 1959 Jul;28:329–346. [PubMed] [Google Scholar]
  4. Lachmann P. J., Nicol P. Reaction mechanism of the alternative pathway of complement fixation. Lancet. 1973 Mar 3;1(7801):465–467. doi: 10.1016/s0140-6736(73)91886-2. [DOI] [PubMed] [Google Scholar]
  5. Mauer S. M., Sutherland D. E., Howard R. J., Fish A. J., Najarian J. S., Michael A. F. The glomerular mesangium. 3. Acute immune mesangial injury: a new model of glomerulonephritis. J Exp Med. 1973 Mar 1;137(3):553–570. doi: 10.1084/jem.137.3.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Peters D. K., Martin A., Weinstein A., Cameron J. S., Barratt T. M., Ogg C. S., Lachmann P. J. Complement studies in membrano-proliferative glomerulonephritis. Clin Exp Immunol. 1972 Jul;11(3):311–320. [PMC free article] [PubMed] [Google Scholar]
  7. Rothfield N., Ross H. A., Minta J. O., Lepow I. H. Glomerular and dermal depostion of properdin in systemic lupus erythematosus. N Engl J Med. 1972 Oct 5;287(14):681–685. doi: 10.1056/NEJM197210052871402. [DOI] [PubMed] [Google Scholar]
  8. Spitzer R. E., Vallota E. H., Forristal J., Sudora E., Stitzel A., Davis N. C., West C. D. Serum C'3 lytic system in patients with glomerulonephritis. Science. 1969 Apr 25;164(3878):436–437. doi: 10.1126/science.164.3878.436. [DOI] [PubMed] [Google Scholar]
  9. Thompson R. A. C3 inactivating factor in the serum of a patient with chronic hypocomplementaemic proliferative glomerulo-nephritis. Immunology. 1972 Jan;22(1):147–158. [PMC free article] [PubMed] [Google Scholar]
  10. Westberg N. G., Naff G. B., Boyer J. T., Michael A. F. Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia. J Clin Invest. 1971 Mar;50(3):642–649. doi: 10.1172/JCI106534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Williams D. G., Kourilsky O., Morel-Maroger L., Peters D. K. C3 breakdown by serum from patients with acute post-streptococcal nephritis. Lancet. 1972 Aug 19;2(7773):360–361. doi: 10.1016/s0140-6736(72)91740-0. [DOI] [PubMed] [Google Scholar]
  12. Williams D. G., Lachmann P. J., Charlesworth J. A., Peters D. K. Role of C3b in the breakdown of C3 in hypocomplementaemic mesangiocapillary glomerulonephritis. Lancet. 1973 Mar 3;1(7801):447–449. doi: 10.1016/s0140-6736(73)91877-1. [DOI] [PubMed] [Google Scholar]

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