Abstract
A prospective study of 78 neonates provides evidence for an association between maternal oxytocin infusion and neonatal jaundice. On the second and fifth days infants of mothers whose labour had been induced by amniotomy followed immediately by intravenous oxytocin (group C) had mean total bilirubin levels significantly higher (P <0·05) than did infants whose mothers had had a spontaneous onset of labour and did not require oxytocin (group A). Bilirubin levels in infants of mothers whose onset of labour was spontaneous but required oxytocin to accelerate progress (group B) did not differ significantly from group A.
Though these findings suggest a dose dependent effect of oxytocin, other possible explanations are suggested which take into account other drugs administered to the mother and also differences in the corticosteroid status of the groups of infants.
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- ARIAS I. M., GARTNER L. M., SEIFTER S., FURMAN M. PROLONGED NEONATAL UNCONJUGATED HYPERBILIRUBINEMIA ASSOCIATED WITH BREAST FEEDING AND A STEROID, PREGNANE-3(ALPHA), 20(BETA)-DIOL, IN MATERNAL MILK THAT INHIBITS GLUCURONIDE FORMATION IN VITRO. J Clin Invest. 1964 Nov;43:2037–2047. doi: 10.1172/JCI105078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Curzon G. Tryptophan pyrrolase--a biochemical factor in depressive illness? Br J Psychiatry. 1969 Dec;115(529):1367–1374. doi: 10.1192/bjp.115.529.1367. [DOI] [PubMed] [Google Scholar]
- Ghosh A., Hudson F. P. Oxytocic agents and neonatal hyperbilirubinaemia. Lancet. 1972 Oct 14;2(7781):823–823. doi: 10.1016/s0140-6736(72)92182-4. [DOI] [PubMed] [Google Scholar]
- Lucey J. F. Neonatal jaundice and phototherapy. Pediatr Clin North Am. 1972 Nov;19(4):827–839. doi: 10.1016/s0031-3955(16)32768-7. [DOI] [PubMed] [Google Scholar]
- Murphy B. E. Does the human fetal adrenal play a role in parturition? Am J Obstet Gynecol. 1973 Feb 15;115(4):521–525. doi: 10.1016/0002-9378(73)90400-6. [DOI] [PubMed] [Google Scholar]
- Rose D. P., Braidman I. P. Oral contraceptives, depression, and aminoacid metabolism. Lancet. 1970 May 23;1(7656):1117–1118. doi: 10.1016/s0140-6736(70)92789-3. [DOI] [PubMed] [Google Scholar]
- WHITE D., HAIDAR G. A., REINHOLD J. G. Spectrophotometric measurement of bilirubin concentrations in the serum of the newborn by the use of a microcapillary method. Clin Chem. 1958 Jun;4(3):211–222. [PubMed] [Google Scholar]