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. 1973 Sep 15;3(5880):563–567. doi: 10.1136/bmj.3.5880.563

Possible Role of Hormones in Treatment of Metastatic Testicular Teratomas: Tumour Regression with Medroxyprogesterone Acetate

H J G Bloom, W F Hendry
PMCID: PMC1586827  PMID: 4726928

Abstract

Three patients in a consecutive series of 16 cases of metastatic mallgnant teratoma testis have shown well-marked tumour regression during hormone treatment. In two cases multiple lung metastases had previously failed to respond to actinomycin D therapy, and following treatment with medroxyprogesterone acetate one patient had well-marked selective tumour regression for nine months while the other is alive, well, and free from disease at seven years. The third case was treated with a combination of actinomycin D and medroxyprogesterone acetate and is alive and disease-free at two years.

Attention is drawn to this preliminary study in the hope of stimulating interest in the possible value of hormones, either alone or combined with chemotherapy and irradiation, in the treatment of metastatic testicular teratoma. Multicentre prospective clinical trials are now needed if knowledge is to be advanced in this field.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson D. G. The possible mechanisms of action of progestins on endometrial adenocarcinoma. Am J Obstet Gynecol. 1972 May 15;113(2):195–211. doi: 10.1016/0002-9378(72)90769-7. [DOI] [PubMed] [Google Scholar]
  2. Bloom H. J. Medroxyprogesterone acetate (Provera) in the treatment of metastatic renal cancer. Br J Cancer. 1971 Jun;25(2):250–265. doi: 10.1038/bjc.1971.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cox J. D., Gingerelli F., Ream N. W., Maier J. G. Total pulmonary irradiation for metastases from testicular carcinoma. Radiology. 1972 Oct;105(1):163–167. doi: 10.1148/105.1.163. [DOI] [PubMed] [Google Scholar]
  4. DALY D. W., DOSSETT J. A., JULL J. W. AN OESTROGEN-SECRETING SEX-CHROMATIN-POSITIVE TERATOMA OF THE TESTIS, ASSOCIATED WITH GYNAECOMASTIA. Br J Surg. 1963 Sep;50:816–819. doi: 10.1002/bjs.18005022612. [DOI] [PubMed] [Google Scholar]
  5. DAVIS P. L., SHUMWAY M. H. Tumors of the testicle: temporary suppression of pulmonary metastasis with testosterone. J Urol. 1958 Jul;80(1):62–64. doi: 10.1016/S0022-5347(17)66133-0. [DOI] [PubMed] [Google Scholar]
  6. Duari M. A primary malignant testicular tumour with unusual metastases. Br J Clin Pract. 1967 Apr;21(4):195–200. [PubMed] [Google Scholar]
  7. FEDON M. [Spontaneous regression of pulmonary metastases of a malignant tumor of the testicle]. Chir Ital. 1960 Aug;12:458–488. [PubMed] [Google Scholar]
  8. FRIEDMAN N. B. The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer. 1951 Mar;4(2):265–276. doi: 10.1002/1097-0142(195103)4:2<265::aid-cncr2820040211>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  9. Foley J. F., Lemon H. M., Miller D. M., Kessinger A. The treatment of metastatic testicular tumors. J Urol. 1972 Sep;108(3):439–442. doi: 10.1016/s0022-5347(17)60765-1. [DOI] [PubMed] [Google Scholar]
  10. Hill G. J., 2nd, Sedransk N., Rochlin D., Bisel H., Andrews N. C., Fletcher W., Schroeder J. M., Wilson W. L. Mithramycin (NSC 24559) therapy of testicular tumors. Cancer. 1972 Oct;30(4):900–908. doi: 10.1002/1097-0142(197210)30:4<900::aid-cncr2820300407>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  11. KALLEN B., ROHL L. Steroid influence on testicular tumor growth, studied in tissue culture. J Urol. 1962 Jun;87:906–913. doi: 10.1016/S0022-5347(17)65066-3. [DOI] [PubMed] [Google Scholar]
  12. MYERS L. M. Sex chromatin in teratomas. J Pathol Bacteriol. 1959 Jul;78:43–55. doi: 10.1002/path.1700780106. [DOI] [PubMed] [Google Scholar]
  13. Mackenzie A. R. Chemotherapy of metastatic testis cancer. Results in 154 patients. Cancer. 1966 Oct;19(10):1369–1376. doi: 10.1002/1097-0142(196610)19:10<1369::aid-cncr2820191006>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  14. Rivarola M. A., Camacho A. M., Migeon C. J. Effect of treatment with medroxyprogesterone acetate (Provera) on testicular function. J Clin Endocrinol Metab. 1968 May;28(5):679–684. doi: 10.1210/jcem-28-5-679. [DOI] [PubMed] [Google Scholar]
  15. Ronzoni G., Milano S., Wiel Marin A., Pagliari G. Effetto della prlungata somministrazione di un antiandrogeno (medroxssi-progesterone acetato), ad alte dosi, sulla funzionalità testicolare del ratto. Chir Patol Sper. 1969 Jun;17(2):101–110. [PubMed] [Google Scholar]
  16. SHIVERS C. H., AXILROD H. D. Clinical effect of estrogen therapy on metastatic lesions from carcinoma of testis. J Urol. 1952 Apr;67(4):537–542. doi: 10.1016/S0022-5347(17)68385-X. [DOI] [PubMed] [Google Scholar]
  17. Samuels M. L., Sullivan P., Howe C. D. Medroxyprogesterone acetate in the treatment of renal cell carcinoma (hypernephroma). Cancer. 1968 Sep;22(3):525–532. doi: 10.1002/1097-0142(196809)22:3<525::aid-cncr2820220306>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  18. Smithers D. W. Chemotherapy for metastatic teratomas of the testis. Br J Urol. 1972 Apr;44(2):217–228. doi: 10.1111/j.1464-410x.1972.tb10068.x. [DOI] [PubMed] [Google Scholar]
  19. van der Werf-Messing B. The treatment of pulmonary metastases of malignant teratoma of the testis. Clin Radiol. 1973 Jan;24(1):121–123. doi: 10.1016/s0009-9260(73)80130-8. [DOI] [PubMed] [Google Scholar]

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