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. 1973 Sep 22;3(5881):612–615. doi: 10.1136/bmj.3.5881.612

Measles and Other Virus-specific Immunoglobulins in Multiple Sclerosis

Margaret Haire, K B Fraser, J H D Millar
PMCID: PMC1586870  PMID: 4356870

Abstract

Immunoglobulins M and G specific for meales, herpes simplex, and rubella viruses were assayed by the fluorescent antibody method in sera and cerebrospinal fluids (C.S.F.) obtained simultaneously from 30 patients with multiple sclerosis, 30 patients with other neurological diseases, and 30 “normal” control subjects. Sera of 11 out of 30 patients with multiple sclerosis had IgM which reacted specifically with measles virus-infected cells, compared with 2 out of 30 of the patients with other neurological diseases and none of the 30 normal controls. Virus-specific IgM was not found in C.S.F. by this method.

The geometric mean titre of measles virus-specific IgG in serum was significantly higher in the multiple sclerosis group than in either control group, and while IgG specific for all three viruses was found in C.S.F., suggesting transfer across the blood-brain barrier, measles IgG predominated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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