Abstract
Study of 182 newborn babies has shown that among bottle-fed infants the mean plasma bilirubin concentration was slightly but significantly higher (P <0·01) in those whose mothers had previously used steroid contraceptives. A similar finding was not noted among breast-fed infants.
A further 16 infants whose mothers had received progestogen therapy during their pregnancy had a mean plasma bilirubin concentration which was significantly higher than each of the four other groups of infants studied (P <0·01). Icterus occasionally reached clinically important levels in these babies.
Full text
PDF![605](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3c/1586921/ccc1b1a76fed/brmedj01576-0015.png)
![606](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3c/1586921/7b8436d74e50/brmedj01576-0016.png)
![607](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3c/1586921/b2d541719d98/brmedj01576-0017.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adlard B. P., Lathe G. H. Breast milk jaundice: effect of 3-alpha 20-beta-pregnanediol on bilirubin conjugation by human liver. Arch Dis Child. 1970 Apr;45(240):186–189. doi: 10.1136/adc.45.240.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Adlard B. P., Lathe G. H. Do steroids contribute to newborn jaundice? Proc R Soc Med. 1971 May;64(5):504–505. [PMC free article] [PubMed] [Google Scholar]
- Arthur L. J., Bevan B. R., Holton J. B. Neonatal hyperbilirubinaemia and breast feeding. Dev Med Child Neurol. 1966 Jun;8(3):279–284. doi: 10.1111/j.1469-8749.1966.tb01748.x. [DOI] [PubMed] [Google Scholar]
- Crawford J. S. Pre-pregnancy oral contraceptives and respiratory-distress syndrome. Lancet. 1973 Apr 21;1(7808):858–860. doi: 10.1016/s0140-6736(73)91422-0. [DOI] [PubMed] [Google Scholar]
- DICZFALUSY E., MAGNUSSON A. M. Tissue concentration of oestrone, oestradiol-17 beta and oestriol in human foetus. Acta Endocrinol (Copenh) 1958 Jun;28(2):169–185. doi: 10.1530/acta.0.0280169. [DOI] [PubMed] [Google Scholar]
- Ghosh A., Hudson F. P. Oxytocic agents and neonatal hyperbilirubinaemia. Lancet. 1972 Oct 14;2(7781):823–823. doi: 10.1016/s0140-6736(72)92182-4. [DOI] [PubMed] [Google Scholar]
- Lauritzen C., Lehmann W. D. The significance of steroid hormones for the development of hyperbilirubinaemia and icterus in the newborn infant. J Endocrinol. 1967 Oct;39(2):183–188. doi: 10.1677/joe.0.0390183. [DOI] [PubMed] [Google Scholar]
- Mitchell F. L. Steroid metabolism in the fetoplacental unit and in early childhood. Vitam Horm. 1967;25:191–269. doi: 10.1016/s0083-6729(08)60037-0. [DOI] [PubMed] [Google Scholar]
- Odell G. B. "Physiologic" hyperbilirubinemia in the neonatal period. N Engl J Med. 1967 Jul 27;277(4):193–195. doi: 10.1056/NEJM196707272770406. [DOI] [PubMed] [Google Scholar]
- WOOD B. S., CULLEY P. E., WATERHOUSE J. A., POWELL D. J. Factors influencing neonatal jaundice. Arch Dis Child. 1962 Aug;37:371–377. doi: 10.1136/adc.37.194.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wong Y. K., Wood B. S. Breast-milk jaundice and oral contraceptives. Br Med J. 1971 Nov 13;4(5784):403–404. doi: 10.1136/bmj.4.5784.403. [DOI] [PMC free article] [PubMed] [Google Scholar]